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High DPP-4 concentr...
High DPP-4 concentrations in adolescents are associated with low intact GLP-1
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- Stenlid, Rasmus (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa
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- Manell, Hannes (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa
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- Halldin, Maria, 1957- (author)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Kullberg, Joel, 1979- (author)
- Uppsala universitet,Radiologi,Antaros Med, SE-43183 Molndal, Sweden
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi,Antaros Med, SE-43183 Molndal, Sweden
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- Manukyan, Levon (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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Weghuber, D (author)
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Paulmichl, K (author)
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Zsoldos, F (author)
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- Bergsten, Peter (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa
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- Forslund, Anders, 1961- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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(creator_code:org_t)
- 2018-05-29
- 2018
- English.
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In: Journal of Clinical Endocrinology and Metabolism. - : Endocrine Society. - 0021-972X .- 1945-7197. ; 103:8, s. 2958-2966
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Context: Dipeptidyl Peptidase-4 (DPP-4) metabolizes glucagon-like peptide-1 (GLP-1) and increased DPP4 levels are associated with obesity and visceral adiposity in adults.Objective: Investigating DPP-4 levels in adolescents and association with, firstly, circulating intact GLP-1 levels and glucose tolerance, secondly, BMI, and, thirdly visceral, subcutaneous and liver fat compartments.Design: Cross-sectional study, July 2012 to April 2015.Setting: Pediatric obesity clinic, Uppsala University Hospital.Patients and participants: Children and adolescents with obesity (n=59) and lean controls (n=21), age 8-18.Main outcome measures: BMI SDS, fasting plasma concentrations of DPP-4, total and intact GLP-1, fasting and OGTT concentrations of glucose and visceral (VAT) and subcutaneous (SAT) adipose tissue volumes and liver fat fraction.Results: Plasma DPP-4 decreased with age both in obese (41 ng/ml per year) and lean subjects (48 ng/ml per year). Plasma DPP-4 was higher in males both in the obesity and lean group. When adjusting for age and sex, plasma DPP-4 was negatively associated with intact GLP-1 at fasting, B=-12.3, 95% CI [-22.9, -1.8] and during OGTT, B=-12.1, 95% CI [-22.5, -1.7]. No associations were found between DPP-4 and plasma glucose measured at fasting or after a 2-hour OGTT. Plasma DPP-4 was 19% higher in the obese subjects. Among adipose tissue compartments the strongest association was with VAT, B=0.05, 95% CI [-0.02, 0.12].Conclusions: In adolescents, high plasma DPP-4 concentrations are associated with low proportion of intact GLP-1, high BMI, young age and male sex. The observed associations are compatible with an increased metabolism of GLP-1 in childhood obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (subject category)
- art (subject category)
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Stenlid, Rasmus
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Manell, Hannes
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Halldin, Maria, ...
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Kullberg, Joel, ...
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Ahlström, Håkan, ...
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Manukyan, Levon
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show more...
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Weghuber, D
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Paulmichl, K
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Zsoldos, F
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Bergsten, Peter
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Forslund, Anders ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Journal of Clini ...
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Uppsala University