Sökning: WFRF:(Weibull Caroline E)
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Pregnancy and the R...
Pregnancy and the Risk of Relapse in Patients Diagnosed With Hodgkin Lymphoma
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- Weibull, Caroline E (författare)
- Karolinska Institutet
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- Eloranta, Sandra (författare)
- Karolinska Institutet
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- Smedby, Karin E (författare)
- Karolinska Institutet
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- Björkholm, Magnus (författare)
- Karolinska Institutet
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- Kristinsson, Sigurdur Y (författare)
- Karolinska Institutet
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- Johansson, Anna L V (författare)
- Karolinska Institutet
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- Dickman, Paul W (författare)
- Karolinska Institutet
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- Glimelius, Ingrid (författare)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 34:4, s. 337-
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- PURPOSE: Many patients and clinicians are worried that pregnancy after the diagnosis of Hodgkin lymphoma (HL) may increase the risk of relapse despite a lack of empirical evidence to support such concerns. We investigated if an association exists between pregnancy and relapse in women with a diagnosis of HL.MATERIALS AND METHODS: Using Swedish healthcare registers combined with medical records, we included 449 women who received a diagnosis of HL between 1992 and 2009 and who were age 18 to 40 years at diagnosis. Follow-up started 6 months after diagnosis, when the patients' condition was assumed to be in remission. Pregnancy-associated relapse was defined as a relapse during pregnancy or within 5 years after delivery. Hazard ratios (HRs) with 95% CIs were estimated by using the Cox proportional hazards model.RESULTS: Among the 449 women, 144 (32%) became pregnant during follow-up. Overall, 47 relapses were recorded, of which one was a pregnancy-associated relapse. The adjusted HR for the comparison of the pregnancy-associated relapse rate to the non-pregnancy-associated relapse rate was 0.29 (95% CI, 0.04 to 2.18). The expected number of relapses in women with a recent pregnancy, given that they would experience the same relapse rate as that of women without a recent pregnancy, was 3.76; the observed-to-expected ratio was 0.27 (95% exact CI, 0.01 to 1.51).CONCLUSION: We found no evidence that a pregnancy after diagnosis increases the relapse rate among women whose HL is in remission. Survivors of HL need to consider a range of factors when deciding about future reproduction. However, given the results of this study, the risk of pregnancy-associated relapse does not need to be considered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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