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High prevalence rat...
High prevalence rates of adult silent coeliac disease, as seen in Sweden, must be expected in Denmark
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Weile, B (författare)
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- Grodzinsky, Ewa, 1958- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin
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- Skogh, Thomas, 1952- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Reumatologi,Länskliniken för Reumatologi i Östergötland
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visa fler...
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Jordal, R (författare)
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Cavell, B (författare)
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Krasilnikoff, PA (författare)
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visa färre...
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - 0903-4641 .- 1600-0463. ; 109:11, s. 745-750
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Aim: To disclose the prevalence of adult "silent" coeliac disease in Denmark and Sweden. Experimental design: 1573 Danish and 1866 Swedish healthy blood donors were screened for the presence of serum anti-gliadin antibodies (AGA) by enzyme-linked immunosorbent assay. AGA-positive serum samples were further analysed for IgA anti-endomysium antibodies (EmA) by indirect immunofluorescence microscopy. Main results: The Danish donor population had a higher mean age than the Swedish (41.4 years versus 37.6 years) and a higher proportion of females (41% versus 32%), and had a lower mean level of AGA (17.3 units versus 20.6 units). Sixty-one (3.9%) Danish donors had AGA above the cut-off limit, and four of these also had positive EmA tests. Sixty (3.2%) Swedish donors had AGA above the cut-off limit, and five of these also had positive EmA. Coeliac pathology was proven by biopsy in all five coeliac disease-suspected Swedish donors. No small intestinal biopsy was performed in the coeliac disease-suspected Danish donors. Conclusions: Based upon the finding of EmA in AGA-positive serum samples, silent coeliac disease may be suspected in 1 per 394 Danish blood donors (2.5 per 1,000). A similar rate was proven in 1 per 373 Swedish blood donors (2.7 per 1,000), indicating no major differences in the prevalence of adult silent coeliac disease between the two neighbouring countries.
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