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Cosegregation of re...
Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
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- Blanc, Caroline (författare)
- Laboratory of Biology and Modeling of the Cell, Ecole Normale Supérieure de Lyon, CNRS UMR 5239, Inserm U1293, University Claude Bernard Lyon 1, Lyon, France.
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- Saclier, Nathanaelle (författare)
- Institut des Sciences de l'Evolution, Université Montpellier, Institut de Recherche pour le Développement, 34090 Montpellier, France.
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- Le Faou, Ehouarn (författare)
- University of Rennes, CNRS, ECOBIO (Ecologie, Biodiversité, Evolution)–UMR 6553, F-35000 Rennes, France.
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- Marie-Orleach, Lucas (författare)
- University of Rennes, CNRS, ECOBIO (Ecologie, Biodiversité, Evolution)–UMR 6553, F-35000 Rennes, France.
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- Wenger, Eva (författare)
- Laboratory of Biology and Modeling of the Cell, Ecole Normale Supérieure de Lyon, CNRS UMR 5239, Inserm U1293, University Claude Bernard Lyon 1, Lyon, France.
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- Diblasi, Celian (författare)
- Institut des Sciences de l'Evolution, Université Montpellier, Institut de Recherche pour le Développement, 34090 Montpellier, France.
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- Glemin, Sylvain (författare)
- Uppsala universitet,Växtekologi och evolution,University of Rennes, CNRS, ECOBIO (Ecologie, Biodiversité, Evolution)–UMR 6553, F-35000 Rennes, France.
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- Galtier, Nicolas (författare)
- Institut des Sciences de l'Evolution, Université Montpellier, Institut de Recherche pour le Développement, 34090 Montpellier, France.
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- Delattre, Marie (författare)
- Laboratory of Biology and Modeling of the Cell, Ecole Normale Supérieure de Lyon, CNRS UMR 5239, Inserm U1293, University Claude Bernard Lyon 1, Lyon, France.
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Laboratory of Biology and Modeling of the Cell, Ecole Normale Supérieure de Lyon, CNRS UMR 5239, Inserm U1293, University Claude Bernard Lyon 1, Lyon, France Institut des Sciences de l'Evolution, Université Montpellier, Institut de Recherche pour le Développement, 34090 Montpellier, France. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2023
- 2023
- Engelska.
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 9:34
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In asexual animals, female meiosis is modified to produce diploid oocytes. If meiosis still involves recombination, this is expected to lead to a rapid loss of heterozygosity, with adverse effects on fitness. Many asexuals, however, have a heterozygous genome, the underlying mechanisms being most often unknown. Cytological and population genomic analyses in the nematode Mesorhabditis belari revealed another case of recombining asexual being highly heterozygous genome-wide. We demonstrated that heterozygosity is maintained despite recombination because the recombinant chromatids of each chromosome pair cosegregate during the unique meiotic division. A theoretical model confirmed that this segregation bias is necessary to account for the observed pattern and likely to evolve under a wide range of conditions. Our study uncovers an unexpected type of non-Mendelian genetic inheritance involving cosegregation of recombinant chromatids.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
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