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- Albrektsson, Tomas, 1945, et al.
(författare)
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Oral implant surfaces: Part 1--review focusing on topographic and chemical properties of different surfaces and in vivo responses to them
- 2004
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Ingår i: Int J Prosthodont. ; 17:5, s. 536-43
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: This article reviews the topographic and chemical properties of different oral implant surfaces and in vivo responses to them. MATERIALS AND METHODS: The article considers detailed mechanical, topographic, and physical characteristics of implant surfaces. Anchorage mechanisms such as biomechanical and biochemical bonding are examined. Osteoattraction and doped surfaces are discussed. RESULTS: Surface quality of an oral implant may be subdivided into mechanical, topographic, and physicochemical properties. Topographic properties are evaluated at the micrometer level of resolution. Moderately rough surfaces (Sa between 1.0 and 2.0 microm) show stronger bone responses than smoother or rougher surfaces. The majority of currently marketed implants are moderately rough. Oral implants permit bone ingrowth into minor surface irregularities-biomechanical bonding or osseointegration. Additional biochemical bonding seems possible with certain surfaces. Osteoattraction is a commercial term without precise biologic correspondence. Surfaces doped with biochemical agents such as bone growth factors have been developed. CONCLUSION: Moderately roughened surfaces seem to have some clinical advantages over smoother or rougher surfaces, but the differences are small and often not statistically significant. Bioactive implants may offer some promise.
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- Albrektsson, Tomas, 1945, et al.
(författare)
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Oral implant surfaces: Part 2--review focusing on clinical knowledge of different surfaces
- 2004
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Ingår i: Int J Prosthodont. ; 17:5, s. 544-64
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: This article reviews clinical knowledge of selected oral implant surfaces. MATERIALS AND METHODS: The surfaces most commonly used in clinical practice, marketed by the five largest oral implant companies, are identified; their clinical documentation was scrutinized following a strict protocol. Experimental knowledge of the surfaces is briefly summarized. Retrospective, prospective, and comparative clinical studies were analyzed separately, as were studies of implants in conjunction with bone grafts. RESULTS: TiUnite anodized surfaces are clinically documented in 1- to 2-year follow-up studies at best, with failures at about 3%. Sandblasted and acid-etched SLA surfaces are documented with good clinical results for up to 3 years. Osseotite dual acid-etched implants are documented with good clinical results for up to 5 years. Frialit-2 sandblasted and etched implants are positively documented for about 3 years in one study only. The Tioblast implant is the only design documented for survival over 10 years of follow-up and success over 7 years of follow-up. CONCLUSION: Generally, oral implants are introduced clinically without adequate clinical documentation. Implant companies initiate clinical documentation after product launch. The standards of clinical reporting have improved over the years. Proper long-term reports have been published for only one surface, Tioblast.
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- Arvidsson, Anna, 1973, et al.
(författare)
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Characterisation of structures in salivary secretion film formation. An experimental study with atomic force microscopy
- 2004
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Ingår i: Biofouling. - : Informa UK Limited. - 0892-7014 .- 1029-2454. ; 20:3, s. 181-8
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present study was to characterise the structure dynamics of pure salivary secretions retained on controlled surfaces with different surface energies in the early stage of salivary film formation. Germanium prisms prepared to have either low surface energy or medium surface energy were incubated in fresh secretions of either human parotid saliva (HPS) or human submandibular/sublingual saliva (HSMSLS) for 15, 90, and 180 min. After controlled rinsing with distilled water, the surfaces were air dried and thereafter imaged with atomic force microscopy (AFM). The amount of adsorbed material and the size of the structures detected increased with increased saliva exposure time. The film thicknesses varied from 10 to 150 nm, and both HPS and HSMSLS films contained structures with diameters varying from 40 nm to 2 microm. Some of these were clustered into special formations. The HPS films exhibited a more granular morphology than the HSMSLS films. Furthermore, branched lines were detected on the low surface energy germanium prisms incubated in saliva. The results indicate that exposure time, surface energy, and type of salivary secretion all are factors affecting the adsorption characteristics of salivary films.
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- Arvidsson, Anna, 1973, et al.
(författare)
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Influence of chemo-mechanical caries removal on the surface topography of dental composite resin and glass-ionomer materials: an in vitro study
- 2004
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Ingår i: Acta Odontologica Scandinavica. ; 62:3, s. 137-142
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to investigate the influence of a chemo-mechanical caries removal system, Carisolv gel, on the surface topography of dental filling materials. Thirty specimens of a composite resin (Spectrum) and a compomer (Dyract AP) and 60 specimens of a glass-ionomer (Ketac-Fil Plus) were prepared. The surface topography was investigated with an optical interferometer before and after chemical exposure for 5, 10, or 20 min. Each specimen acted as its own control. The topographical part of the glass-ionomer materials was performed in two series with different drying procedures, since this material exhibits a higher sensitivity to dehydration than the other materials. The surface topographical investigations were complemented with contact angle measurements. After Carisolv gel exposure the density of summits and the developed surface area ratio (3D/2D) were slightly smaller for the composite resin and the compomer. For the minimally dried glass-ionomer material, the results indicated a reduction of the height of the surface structures, as well as a surface area enlargement, after Carisolv gel exposure. No statistically significant changes of contact angles due to Carisolv gel exposure could be detected for any material investigated. If dental filling materials of composite resin or glass-ionomer materials are exposed to Carisolv gel, no or only minor surface topographical changes can be expected.
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- Ellingsen, Jan Eirik, et al.
(författare)
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Improved Retention and Bone-to-Implant Contact with Fluoride-Modified Titanium Implants
- 2004
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Ingår i: International Journal of Oral & Maxillofacial Implants. - Chicago, Ill.] : Quintessence Pub. Co.. - 0882-2786 .- 1942-4434. ; 19:5, s. 659-666
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of the present study was to investigate whether a fluoride modification of the titanium surface would have an effect on bone response after implantation. Materials and Methods: Titanium-oxide–blasted titanium implants with and without fluoride modification were investigated in a rabbit tibia model. Quantitative analysis of surface roughness, biomechanical interlocking, and in vivo tissue reactions in rabbit bone at 1 and 3 months after placement were compared. Results: The fluoride-modified test implants had a slightly smoother surface (Sa: 0.91 ± 0.14 µm) than the unmodified control implants (Sa: 1.12 ± 0.24 µm). Significantly higher removal torque values (85 ± 16 Ncm vs 54 ± 12 Ncm) and shear strength between bone and implants (23 ± 9 N/mm2 vs 15 ± 5 N/mm2) were measured for the fluoride-modified implants after 3 months. The histomorphometric evaluations demonstrated higher bone-to-implant contact for test implants at 1 month (35% ± 14% vs 26% ± 8%) and 3 months (39% ± 11% vs 31% ± 6%) after placement. Discussion: Implant surface modification with fluoride may result in morphologic and physiochemical phenomena that are of significance for the bone response. Another possible explanation for the findings in the present study is that a surface modification changes the surface chemical structures to be more suitable for bone bonding. Conclusion: Based on the biomechanical and histomorphometric data, the fluoride-modified titanium implants demonstrated a firmer bone anchorage than the unmodified titanium implants. These implants achieved greater bone integration than unmodified titanium implants after a shorter healing time. (More than 50 references.)
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- Ellingsen, Jan Eirik, et al.
(författare)
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Improved retention and bone-tolmplant contact with fluoride-modified titanium implants.
- 2004
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Ingår i: International Journal of Oral & Maxillofacial Implants. - 0882-2786. ; 19:5, s. 659-66
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: The purpose of the present study was to investigate whether a fluoride modification of the titanium surface would have an effect on bone response after implantation. MATERIALS AND METHODS: Titanium-oxide-blasted titanium implants with and without fluoride modification were investigated in a rabbit tibia model. Quantitative analysis of surface roughness, biomechanical interlocking, and in vivo tissue reactions in rabbit bone at 1 and 3 months after placement were compared. RESULTS: The fluoride-modified test implants had a slightly smoother surface (Sa: 0.91 +/- 0.14 microm) than the unmodified control implants (Sa: 1.12 +/- 0.24 microm). Significantly higher removal torque values (85 +/- 16 Ncm vs 54 +/- 12 Ncm) and shear strength between bone and implants (23 +/- 9 N/mm2 vs 15 +/- 5 N/mm2) were measured for the fluoride-modified implants after 3 months. The histomorphometric evaluations demonstrated higher bone-to-implant contact for test implants at 1 month (35% +/- 14% vs 26% +/- 8%) and 3 months (39% +/- 11% vs 31% +/- 6%) after placement. DISCUSSION: Implant surface modification with fluoride may result in morphologic and physiochemical phenomena that are of significance for the bone response. Another possible explanation for the findings in the present study is that a surface modification changes the surface chemical structures to be more suitable for bone bonding. CONCLUSION: Based on the biomechanical and histomorphometric data, the fluoride-modified titanium implants demonstrated a firmer bone anchorage than the unmodified titanium implants. These implants achieved greater bone integration than unmodified titanium implants after a shorter healing time.
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- Göransson, Anna, 1970, et al.
(författare)
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Inflammatory response to oxidised surface with Mg 2+ -ions incorporated in vitro
- 2004
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Ingår i: 7th World Biomaterials Congress, Sidney, 17 -21 May 2004.
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Konferensbidrag (refereegranskat)abstract
- Introduction Oxide films that grow spontaneously on titanium surfaces in contact with air may explain the bio-passivity of the material. Various procedures have been carried out to modify the properties of titanium oxide films to further improve the biocompatibility. Anodic oxidation is one technique to increase the thickness of the oxide layer that demonstrates significant stronger bone response in vivo. The concomitant increase in surface roughness and size and presence of pores of the thicker oxide layer seems to work as a potential contributor to the results (1). Attempts to implant ion in the oxide layers to overcome the drawbacks of calcium phosphate coatings (hydroxylapatite) such as i.e. delaminating and biodegradation during function seem promising (2). However the reasons why a thicker oxide layer with and without incorporated ions is favourable compared to conventionally turned and blasted surfaces are not fully understood. The aim of this study was to compare the early inflammatory response to the turned, blasted and electrochemically oxidised surface with Mg 2+ ions incorporated. Materials and Methods A total of 108 pure titanium discs were prepared with a turned surface. Thirty-six were kept as turned controls while 36 were blasted with 75 μm Al2O3 particles and 36 underwent electrochemically oxidation and Mg 2+ ion incorporation. MicroXam™, (Phase-Shift, Tucson, Arizona, USA) was used to for topographical characterisation. The disks were incubated with human mononuclear cells isolated from buffy coats of healthy blood donors (C-lab, Blood Supply Unit Sahlgrenska University hospital, Sweden) and cultured at a concentration of 106 cells/ml in 24 well cell culture plates. Half of the discs with the different treated surfaces were immediately treated with LPS while half were left without any stimuli. The incubation times were 24 and 72h. After each incubation period the incubation medium was collected and centrifuged. The supernatant was analysed with respect to cell viability and cytokine levels. Cell viability was estimated by analysing the content of lactatdehydrogenas (LDH)(Sahlgrenska University hospital, C-lab) and a commercially available ELISA assay (Biotrak system™, Amersham Bioscience, UK) was used to quantify TNF-α and IL -10 levels. The cells adherent to the material was stained with 2,6- diamidino-2-phenyindole (DAPI) (Sigma, USA) to evaluate the total cell number. In order to characterize differentiation of the adherent cells expression of 27E10 and RM3/1 (Biogenisis, UK) was used. The marker 27E10 and RM3/1 define acute and chronic inflammatory phenotypes respectively. Differentiated cells were evaluated as the percentage of positively stained cells from the total cell numbers. Results Surface evaluation revealed similar roughness for the turned control and the anodised surface with Mg 2+ ions incorporated while the blasted surface demonstrated a rougher surface profile (fig 1, 2). Fig 1 Fig 2 Sa-average height deviation (ym) SURFACE CTR Blasted Anodised+Mg Mean SA 1,2 1,0 ,8 ,6 ,4 ,2 0,0 Sdr-developed surface area (%) SURFACE CTR Blasted Anodised+Mg Mean SDR 40 30 20 10 0 LDH values were generally low for all surfaces (within the range of 0.8-1.6 μkat/l) but were slightly increased after LPS stimulation and after 72h. TNF-α was transient higher day one and after LPS stimulation especially on the turned control surface (fig 3, 4) Fig 3 Fig 4 TNF-a 24h (pg/ml) SURFACE CTR Blasted Anodised+Mg Mean C 3000 2000 1000 0 LPS LPSLPS+ TNF-a 72h (pg/ml) SURFACE CTR Blasted Anodised+Mg Mean C 400 300 200 100 0 LPS LPSLPS+ IL-10 levels were generally low irrespective of time. Increased IL-10 amounts after LPS stimulation and after 24 h were observed for all surfaces. The total cell numbers decreased on all surfaces from 24h to 72h but there were no major difference between stimulated and un-stimulated wells. Acute monocytic phenotype 27E10 marker dominated on all surfaces while the expression of the chronic RM3/1 marker was almost absent on all surfaces both at 24 and 72h. Conclusion The present study indicates a surface topography- and chemistry related difference in the acute inflammatory response with a stronger acute inflammatory response to the turned control compared to the blasted and anodised surface with Mg 2+ ions incorporated. References 1.Göransson, A, Jansson, E, Tengvall, P, Wennerberg, A. Bone formation after 4 weeks …topography : an in vivo study. Biomaterials 2002; 24: 197-205 2.Sul YT. PhD Thesis 2002, Göteborg University, Sweden
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