Sökning: WFRF:(Wennstig Anna Karin 1973 )
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Risk of coronary st...
Risk of coronary stenosis after adjuvant radiotherapy for breast cancer
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- Wennstig, Anna-Karin, 1973- (författare)
- Umeå universitet,Kirurgi,Department of Oncology, Sundsvall Hospital, Sundsvall, Sweden
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- Garmo, H. (författare)
- Regional Cancer Center, Uppsala University/Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ, Reg Canc Ctr, Uppsala Univ Hosp, Uppsala, Sweden.
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- Wadsten, L. (författare)
- Umeå universitet,Kirurgi,Department of Surgery, Sundsvall Hospital, Sundsvall, Sweden,Umeå Univ, Dept Surg & Perioperat Sci Surg, Umeå, Sweden.;Sundsvall Hosp, Dept Surg, Sundsvall, Sweden.
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- Lagerqvist, Bo (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Fredriksson, I. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Breast Endocrine Tumors & Sarcoma, Stockholm, Sweden.
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- Holmberg, L. (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Kings Coll London, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, London, England.
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- Blomqvist, C. (författare)
- Department of Oncology, Örebro University, University Hospital, Örebro, Sweden,Örebro Univ, Univ Hosp, Dept Oncol, Örebro, Sweden.
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- Nilsson, G. (författare)
- Department of Immunology, Genetics and Pathology, Section of Experimental and Clinical Oncology, Uppsala University, University Hospital, Uppsala, Sweden; Department of Oncology, Gävle Hospital, Gävle, Sweden; Department of Oncology, Visby Hospital, Visby, Sweden,Uppsala Univ, Univ Hosp, Sect Expt & Clin Oncol, Dept Immunol Genet & Pathol, Uppsala, Sweden.;Gävle Cent Hosp, Dept Oncol, Gävle, Sweden.;Visby Hosp, Dept Oncol, Visby, Sweden.
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- Sund, Malin (författare)
- Umeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland,Umeå Univ, Dept Surg & Perioperat Sci Surg, Umeå, Sweden.;Univ Helsinki, Dept Surg, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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(creator_code:org_t)
- 2022-04-07
- 2022
- Engelska.
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Ingår i: Strahlentherapie und Onkologie (Print). - : Springer Berlin/Heidelberg. - 0179-7158 .- 1439-099X. ; 198, s. 630-638
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose: Adjuvant radiotherapy (RT) for breast cancer is associated with an increased risk of ischemic heart disease. We examined the risk of coronary artery stenosis in a large cohort of women with breast cancer receiving adjuvant RT.Methods: A cohort of women diagnosed with breast cancer between 1992 and 2012 in three Swedish health care regions (n = 57,066) were linked to the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) to identify women receiving RT who subsequently underwent a percutaneous coronary intervention (PCI) due to coronary stenosis. Cox regression analyses were performed to examine risk of a coronary intervention and competing risk analyses were performed to calculate cumulative incidence.Results: A total of 649 women with left-sided breast cancer and 494 women with right-sided breast cancer underwent a PCI. Women who received left-sided RT had a significantly higher risk of a PCI in the left anterior descending artery (LAD) compared to women who received right-sided RT, hazard ratio (HR) 1.44 (95% confidence interval [CI] 1.21–1.77, p < 0.001). For the proximal, mid, and distal LAD, the HRs were 1.60 (95% CI 1.22–2.10), 1.38 (95% CI 1.07–1.78), and 2.43 (95% CI 1.33–4.41), respectively. The cumulative incidence of coronary events at 25 years from breast cancer diagnosis were 7.0% in women receiving left-sided RT and 4.4% in women receiving right-sided RT.Conclusion: Implementing and further developing techniques that lower cardiac doses is important in order to reduce the risk of long-term side effects of adjuvant RT for breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Ischemic heart disease
- LAD (left anterior descending artery)
- PCI (percutaneous coronary intervention)
- Side effects
- Survivorship
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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