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- Lomniczi B., Wehmann E., Herczeg J., Ballagi-Pordany, A., Kaleta, E.F., Werner, O., Meulemans, G., Jorgensen, P.H., Mante, A.P., Gielkens, A.L., Capua, I., and Damoser, J.
(författare)
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Newcastle disease outbreaks in recent years in western Europe were caused by an old (VI) and a novel genotype (VII)
- 1998
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Ingår i: Arch Virol. ; 143:1, s. 49-64
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Bentz, M, et al.
(författare)
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Chromosome imbalances in papillary renal cell carcinoma and first cytogenetic data of familial cases analyzed by comparative genomic hybridization
- 1996
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Ingår i: Cytogenetics and cell genetics. - : S. Karger AG. - 0301-0171. ; 75:1, s. 17-21
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Tidskriftsartikel (refereegranskat)abstract
- We used comparative genomic hybridization to analyze 17 tumor samples from 11 patients with papillary renal cell carcinoma (RCC), including three patients with hereditary papillary RCC. Whereas the most frequent aberrations confirmed data obtained by banding analyses, copy number increases on 5q, which previously were considered characteristic of nonpapillary RCC, were identified in two cases. In two complex cases belonging to the same family, a characteristic pattern of chromosomal aberrations was found: five of the six imbalances present in the less complex case were included in the karyotype of the other case, suggesting a genetically determined mechanism resulting in genomic instability of specific chromosomes or chromosomal subregions and/or selection of specific mutations.
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| 5. |
- LAFOSSE, DR, et al.
(författare)
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EVIDENCE FOR HYPERDEFORMATION IN GD-147
- 1995
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 74:26, s. 5186-5189
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Laihonen, Sari J., et al.
(författare)
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Crystal structure and morphology of melt-crystallized poly(propylene-stat-ethylene) fractions.
- 1997
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Ingår i: Polymer. - 0032-3861 .- 1873-2291. ; 38:2, s. 371-377
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Tidskriftsartikel (refereegranskat)abstract
- Crystallinity, crystal structure and lamellar thickness in melt-crystallized samples of poly(propylene-stat-ethylene) fractions with 2.7–11.0 mol% ethylene comonomer and of approximately constant tacticity were assessed by wide- and small-angle X-ray scattering, differential scanning calorimetry and infra-red spectroscopy. Most of the samples were crystallized under isothermal conditions at 373 K. In comparison with an isotactic homopolymer of polypropylene, the copolymers showed lower crystallinity, melting enthalpy and average length of 3/1 helices, a slightly larger unit cell, a longer long period and an invariant lamellar thickness. The X-ray crystallinity of the copolymers remained approximately constant with increasing ethylene content, whereas the γ-crystallinity increased and the heat of fusion decreased moderately. It is suggested that the ethylene units are partially included in the crystals, and that this causes the invariance in crystallinity and crystal thickness. The observed gradual decrease in average 3/1 helix length with increasing ethylene content as assessed by infra-red spectroscopy is in accordance with this suggestion.
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| 7. |
- Laihonen, Sari J., et al.
(författare)
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Crystallization kinetics and morphology of poly(propylene-stat-ethylene) fractions.
- 1997
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Ingår i: Polymer. - 0032-3861 .- 1873-2291. ; 38:2, s. 361-369
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Tidskriftsartikel (refereegranskat)abstract
- The crystallization and melting behaviour and the morphology of fractions of poly(propylene-stat-ethylene) with 2.7–11.0 mol% ethylene were studied by differential scanning calorimetry, wide-angle X-ray scattering, polarized light microscopy and transmission electron microscopy, after etching with permanganic acid. The inclusion of ethylene co-repeating units in isotactic polypropylene (0–11.0 mol% ethylene) caused approximately linear decreases in kinetic and equilibrium melting temperatures and in the glass transition temperature with increasing ethylene content. X-ray scattering showed that the content of the γ form increased with increasing ethylene content, increasing crystallization temperature and decreasing cooling rate from the molten state. It was shown for one of the copolymers (8.7 mol% ethylene) that during heating approximately 50% of the γ form was converted to the α form before the final melting of the sample. The rest of the γ crystals melted without transformation to the α form. The multimodality of the crystal melting above the crystallization temperature in the polymers with a more uniform crystal structure was caused by recrystallization during heating, whereas polymers with appreciable contents of both α and γ forms exhibited multimodal melting at all the heating rates adopted. The size of the low temperature melting peak as assessed at a heating rate of 40 K min−1 was approximately proportional to the initial content of the γ form. By comparison with the spherulitic structure of homopolymers, that of the copolymers was coarser with internal and peripheral pockets of molten material during spherulite growth. The crystal lamellae exhibited more curvature in the copolymer samples than in the homopolymer.
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| 8. |
- Löfdahl, Claes-Göran, et al.
(författare)
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Differences in bronchodilating potency of salbutamol in Turbuhaler as compared with a pressurized metered-dose inhaler formulation in patients with reversible airway obstruction
- 1997
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 10:11, s. 2474-2478
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Tidskriftsartikel (refereegranskat)abstract
- Two studies are presented, with the aim of establishing the dose potency ratio for salbutamol given via Turbuhaler and via a pressurized metered-dose inhaler (pMDI). Both studies were of a double-blind, randomized design. Outpatients with mild-to-moderate chronic reversible airway obstruction were given single doses of salbutamol administered via Turbuhaler and via pMDI. Efficacy and safety variables were measured before and during 6 h after each dose. The first study was a four-way crossover study including 12 patients. The salbutamol doses given were: 50, 100 and 2x100 microg via Turbuhaler and 2x100 microg via pMDI (Ventolin). The study showed that 2x100 microg of salbutamol inhaled via Turbuhaler is more potent than 2x100 microg salbutamol inhaled via a pMDI, and that 100 microg salbutamol via Turbuhaler is at least as potent as 2x100 microg salbutamol inhaled via a pMDI. The second study including 50 patients was a placebo-controlled five-way crossover, study. Two doses of salbutamol via Turbuhaler, 50 and 2x100 microg, and via pMDI, 100 and 2x200 microg, were given. There was a dose-dependent response in forced expiratory volume in one second (FEV1) for both inhalers. Adjusted for differences in baseline FEV1 values, the estimated relative dose potency for Turbuhaler versus pMDI was 1.98:1 (95% confidence interval 12-3.2). These studies showed that the same bronchodilating effect can be achieved when half the dose of salbutamol given via a conventional pressurized metered-dose inhaler is given via Turbuhaler.
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