| 1. |
- Ecker, Kreske, et al.
(författare)
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Regional differences in initial labour market conditions and dynamics in lifetime income trajectories
- 2022
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Ingår i: Longitudinal and Life Course Studies. - : Bristol University Press. - 1757-9597. ; 13:3, s. 352-379
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Tidskriftsartikel (refereegranskat)abstract
- We use longitudinal register data from Sweden to study patterns and dynamics in lifetime income trajectories. We examine divergences in these income trajectories by local economic conditions at labour market entry, in combination with other factors such as gender, education level and socio-economic background. We cannot assume that these relationships are constant over the course of individuals’ working lives. Therefore, we use methods from functional data analysis, allowing for a time-varying relationship between income and the explanatory variables. Our results show a large degree of heterogeneity in how lifetime income trajectories develop for different subgroups. We find that, for men, entering the labour market in an urban area is associated with higher cumulative lifetime income, especially later in life. The exception is men with only primary education, for whom those starting their working lives in a large city have lower incomes on average. This divergence increases in size over time. Women who enter into a large urban labour market receive higher lifetime income at all education levels. This relationship is strongest for women with primary education but decreases in strength over time for these women.
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| 2. |
- Eliasson, Kent, et al.
(författare)
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Housing markets and geographical labour mobility to high-productivity regions : the case of Stockholm
- 2024
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Ingår i: European Urban and Regional Studies. - : Sage Publications. - 0969-7764 .- 1461-7145. ; 31:3, s. 259-280
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Tidskriftsartikel (refereegranskat)abstract
- In many countries, there are signs of declining migration to high-productivity urban areas due to restrictions in the housing market and increasing regional differences in housing prices. Using detailed population-wide register data for Sweden, we estimate how regional variation in housing prices and homeownership is associated with the individual’s decision whether to accept a job offer in the Stockholm metropolitan region and the interrelated choice between migration and commuting as the mobility mode. Our findings indicate that high relative housing prices in the Stockholm area and homeownership are associated with decreasing total geographical labour mobility to the region. This is pronounced among the young and among highly skilled workers. The negative effects of high relative housing prices and homeownership on migration are partially but not fully compensated by positive effects on commuting to Stockholm.
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| 3. |
- Eliasson, Kent, et al.
(författare)
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Patterns of inter- and intra-regional differences in human capital and earnings : Evidence from Finland and Sweden 1987–2015
- 2021
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Ingår i: Applied Geography. - : Elsevier. - 0143-6228 .- 1873-7730. ; 135
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we examine the long-term patterns of geographical disparities in human capital and income in Finland and Sweden over the period 1987–2015. Using nationwide longitudinal population register data, we analyze disparities at different spatial scales, between and within functional labor market regions determined by observed travel-to-work patterns. Contrary to the findings from many other developed economies indicating inter-regional divergence in per capita income, we find indications of inter-regional convergence in per capita earnings among the functional labor market regions in both countries after 2000. However, small, and peripheral regions have not recovered from the macroeconomic shocks in the 1990s, in terms of per capita earnings. Our estimates indicate relatively small and statistically insignificant changes in the geographical dispersion of human capital at the inter-regional scale. At the intra-regional scale, the disparities in human capital and earnings between the core and hinterlands are relatively large and persistent, although some evidence of convergence is found for Finland. The largest intra-regional differences in human capital and earnings are found within the metropolitan labor markets.
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| 4. |
- Eliasson, Kent, et al.
(författare)
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Regional concentration of university graduates : The role of high school grades and parental background
- 2020
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Ingår i: European Urban and Regional Studies. - : Sage Publications. - 0969-7764 .- 1461-7145. ; 27:4, s. 398-414
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, we analyse long-term changes in the regional distribution and migration flows of university graduates in Finland and Sweden. This study is based on detailed longitudinal population register data, including information on high school grades and parental background. We find a distinct pattern of skill divergence across regions in both countries over the last 3 decades. The uneven distribution of human capital has been reinforced by the mobility patterns of university graduates, for whom regional sorting by high school grades and parental background is evident. Our findings indicate that traditional measures of human capital concentration most likely underscore actual regional differences in productive skills.
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| 5. |
- Eliasson, Kent, et al.
(författare)
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The urban wage premium and spatial sorting on observed and unobserved ability
- 2023
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Ingår i: Journal of Economic Geography. - : Oxford University Press. - 1468-2702 .- 1468-2710. ; 23:3, s. 601-627
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Tidskriftsartikel (refereegranskat)abstract
- We estimate static and dynamic agglomeration effects on earnings among university graduates using Swedish longitudinal population register data. The prime interest lies with whether and how the dynamic effects of big city work experience vary by observed ability of workers and whether the effects are portable after relocation. Urban wage premium and spatial sorting of university graduates are analysed by using information on school grades, parental education and university rank. We find that the value of accumulated big city work experience increases with observed ability. The dynamic premium of working in bigger cities is not lost when moving to smaller cities, suggesting that it reflects learning effects and human capital accumulation. Our findings indicate systematic spatial sorting on observed indicators of ability as well as on unobserved productive traits. Sorting on unobserved abilities is driven primarily by graduates in the upper part of the observed ability distribution and is apparent also when taking dynamic learning effects into consideration.
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| 6. |
- Rosestedt, Maria, et al.
(författare)
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Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1
- 2021
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Ingår i: Nuclear Medicine and Biology. - : Elsevier. - 0969-8051 .- 1872-9614. ; 93, s. 54-62
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionPathological formation of fibrosis, is an important feature in many diseases. Fibrosis in liver and pancreas has been associated to metabolic disease including type 1 and 2 diabetes. The current methods for detecting and diagnosing fibrosis are either invasive, or their sensitivity to detect fibrosis in early stage is limited. Therefore, it is crucial to develop non-invasive methods to detect, stage and study the molecular processes that drive the pathology of liver fibrosis. The peptide LRELHLNNN was previously identified as a selective binder to collagen type I with an affinity of 170 nM. Radiolabelled LRELHLNNN thus constitute a potential PET tracer for fibrosis.MethodLRELHLNNN was conjugated to a DOTA/NOTA moiety via a PEG2-linker. DOTA-PEG2-LRELHLNNN was labelled with Gallium-68 and NOTA- PEG2-LRELHLNNN with aluminium fluoride-18. Biodistribution of [68Ga]Ga-DOTA-PEG2-LRELHLNNN and [18F]AlF-NOTA-PEG2-LRELHLNNN was performed in healthy rats ex vivo and in vivo. The 68Ga-labelled analogue was evaluated in a mouse model of liver fibrosis by PET/MRI-imaging. The human predicted dosimetry of the tracers was extrapolated from rat ex vivo biodistribution studies at 10, 20, 40, 60, 120, 180 min (only fluoride-18) post-injection.ResultsThe peptides were successfully radiolabelled with gallium-68 and aluminium fluoride-18, respectively. The biodistribution of [68Ga]Ga-DOTA-PEG2-LRELHLNNN and [18F]AlF-NOTA-PEG2-LRELHLNNN was favorable showing rapid clearance and low background binding in organs where fibrosis may develop. Binding of [68Ga]Ga-DOTA-PEG2-LRELHLNNN to fibrotic liver was higher than surrounding tissues in mice with induced hepatic fibrosis. However, the binding was in the range of SUV 0.3, indicating limited targeting of the tracer to liver. The extrapolated human predicted dosimetric profiles of [68Ga]Ga-DOTA-PEG2-LRELHLNNN and [18F]AlF-NOTA-PEG2-LRELHLNNN were beneficial, potentially allowing at least three PET examinations annually.ConclusionsWe describe the modification, radiolabelling and evaluation of the collagen type I binding peptide LRELHLNNN. The resulting radiotracer analogues demonstrated suitable biodistribution and dosimetry. [68Ga]Ga-DOTA-PEG2-LRELHLNNN exhibited binding to hepatic fibrotic lesions and is a promising tool for PET imaging of fibrosis.Advances in knowledgeValidation of a new collagen targeting PET tracer.Implications for patient careEarly, non-invasive diagnosis and stratification of fibrosis in order to improve the diagnosis, staging and treatment of patients with diseases involving fibrosis.
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