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- Alestig, Erik, 1973, et al.
(författare)
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Core mutations, IL28B polymorphisms and response to peginterferon/ribavirin treatment in Swedish patients with hepatitis C virus genotype 1 infection
- 2011
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Ingår i: BMC Infectious Diseases. - : Springer Science and Business Media LLC. - 1471-2334. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Background: Patients infected with hepatitis C virus (HCV) genotype 1 respond poorly to standard treatment with 50% or less achieving sustained virologic response. Predicting outcome is essential and could help avoid unnecessary treatment and reduce health cost. Recently, an association of amino acid substitutions in the core region and treatment outcome was observed in Japanese patients. In the present study, the impact of these mutations on response kinetics and treatment outcome was explored in Caucasian patients. Methods: The core region of HCV pre-treatment samples obtained from 50 patients treated with peginterferon/ribavirin in a previous Swedish clinical trial with genotype 1 infection were sequenced. The alleles at rs12979860, a single nucleotide polymorphism (SNP), were assessed in order to identify any co-association with this strong response predictor. Results: No association between treatment response and substitutions of core residue 91 was found. In contrast, substitutions of core residue 70 were observed in 6/21 (29%) non-responders, but only in one of 29 responders (p = 0.03), and were more common in subgenotype 1b (R70Q in 6 of 13 strains) than in 1a (R70P in 1 of 37 strains, p = 0.004). The rs12979860 SNP upstream of the IL28B gene was overall the strongest response predictor (p = 0.0001). Core 70 substitutions were associated with poorer response kinetics in patients carrying the CT genotype at rs12979860. Conclusions: The results indicate that substitutions of core residue 70 are related to treatment response in Caucasian patients with HCV-1b infection, but are of less importance than IL28B polymorphism.
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- Almevik, Gunnar, 1969, et al.
(författare)
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A virtual diorama: Methodologising the digital artefact in cultural heritage research
- 2019
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Ingår i: Current Discourses and Global Challenges, 7-8 November 2019, Critical Heritage Studies, University of Gothenburg.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- During a restoration of the Romanesque church in Hemse in 1896, the remains of a stave church were found as reused floor tiles. The discovery was important at the time, providing new information to a prestigious research field with few sources of knowledge. Today the church’s stave members are esoteric museum artefacts, “re-membered” in various forms of production of history. This poster sets out from an in-deep re-examination and virtual reconstruction of the remains from this stave church. The digital reconstruction functions as a virtual diorama to contextualize the diffused and decontextualized remains and contemporaneous religious artefacts. The aim is methodological, to explore the uses of the digital artefact in the research process. The reconstruction is less of a static representation of our knowledge than a historical laboratory through which archive material can be activated and hypotheses can be tested. We seek to methodologise the virtual diorama, using the technology for testing hypothesis and observe the effects when enacting the environment. The presented research is ongoing and we invite for discussion. How can we, through the digital artefact, elicit the sensuous aspects of a virtual place, and at the same time communicate the rigour of research and display the ambiguities of the reconstruction? How can we in an intelligible way map and reference the archive materials without interfering with the presence effect of the diorama? What are the challenges to present an interactive virtual reality file as a self-standing research output? How can we develop the digital artefact to better engage both researchers and the public in a dialogue on the premises of cultural heritage research?
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- Almevik, Gunnar, 1969, et al.
(författare)
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Built cultural heritage in Antarctica : remains and uses of the first Swedish SouthPolar expedition 1901–1903
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In 1901, Otto Nordenskjöld led the first Swedish South Polar expedition with a multidisciplinary team of researchers in geology, geography, biology and medicine. The original plan was to hibernate in Antarctica and stay for one year to survey the land, measure the climate, and collect samples, but their ship was wrecked and the expedition came to last more than two years. Today, the remains from this expedition are protected as cultural heritage according to the Antarctic Treaty and they have been maintained by Argentinian efforts. Among five protected cultural environments, the wooden research station on Snow Hill Island stands out. Sweden joined the Antarctic Treaty in 1984 but has not actively engaged in the management of cultural heritage there until the CHAQ2020 expedition in 2020. The fieldwork presented in this report was carried out in Antarctica with the purposes of documenting and assessing the condition of the remains and providing a knowledge base for policy and decision-making concerning Swedish cultural heritage in Antarctica.
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- Almevik, Gunnar, 1969, et al.
(författare)
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Hemse Stave Church Revisited
- 2018
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Ingår i: Lund Archaeological Review. - 1401-2189. ; 23, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- During a restoration of the Romanesque church in Hemse in 1896, the remains of a stave church were found as reused floor tiles. The discovery was important at the time, providing new information to a prestigious research field with few sources of knowledge. Today, the remains of Hemse are esoteric and inaccessible for scholarship. The stave church material in the present museum context seems to have one function, to communicate an age value. The leading question in this article is, what more could we retrieve from this old archaeological material? We may agree that the museum’s archaeological collections and the stave church remains are valuable sources, but for what new kind of knowledge? This article presents the process and outcome of an in-depth examination of the material remains and archival records of Hemse stave church. The aim is to develop or revise how this wooden church may have been constructed and appeared both outside and inside when it functioned as a building. The research method uses three perspectives that give access to different paths of knowledge: a discursive perspective, a forensic perspective, and a dwelling perspective. The research results are contextualized in an interactive model of Hemse that provides a visual experience that gives a sense of the stave church as a real place and not just a theoretical space. The results are grounded on empirical evidence but also on the intellectual discourse of which it is a product. The reconstruction is less of a static representation of our knowledge than a simulation or a research laboratory through which hypotheses can be tried and both researchers and the public can be engaged in a dialogue.
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| 8. |
- Almevik, Gunnar, 1969, et al.
(författare)
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Rethinking the Academic Artefacts
- 2022
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Ingår i: Craft Sciences / Tina Westerlund, Camilla Groth and Gunnar Almevik (eds.).. - Göteborg : Acta Universitatis Gothoburgensis. - 2002-2131. ; , s. 22-45
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Bokkapitel (refereegranskat)
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| 10. |
- Alsiö, Åsa, 1965, et al.
(författare)
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Early quantification of HCV core antigen may help to determine the duration of therapy for chronic genotype 2 or 3 HCV infection
- 2012
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Ingår i: European Journal of Clinical Microbiology & Infectious Diseases. - : Springer Science and Business Media LLC. - 0934-9723 .- 1435-4373. ; 31:7, s. 1631-1635
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to evaluate the utility of hepatitis C virus (HCV) core antigen (coreAg) assessment for the identification of candidates for short-term therapy. Plasma samples from HCV genotype 2 or 3-infected patients participating in the NORDynamIC trial (n = 382) comparing 12 and 24 weeks of combination treatment with pegylated interferon-alpha 2a and a fixed dose of 800 mg ribavirin daily were analyzed for coreAg. Among the 126 patients (33% of the intention-to-treat population) achieving HCV coreAg levels in plasma below 0.2 pg/mL when assayed on treatment day 3, sustained viral response (SVR) rates of 86% and 84% were achieved in the 12- and 24-week arms, respectively. Similarly, among patients having received at least 80% of the target dose of both pegylated interferon alpha-2a and of ribavirin for at least 80% of the target treatment duration (per-protocol analysis), the SVR rates were 89% and 95%, respectively. Twelve weeks of combination treatment may be sufficient for genotype 2 or 3-infected patients achieving HCV coreAg levels below 0.2 pg/mL by day 3, signaling a rapid clearance of HCV viremia.
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