| 1. |
- Heid, Iris M, et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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| 2. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 3. |
- AlNasseri, Hammad Abdullah, et al.
(författare)
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Towards a Taxonomy of Planning and Scheduling Methods in the Context of Construction Management.
- 2013
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Ingår i: [Host publication title missing]. - Trondheim : Akademika forlag. - 9788232102730 ; , s. 570-581
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Konferensbidrag (refereegranskat)abstract
- Planning and scheduling are considered as one of the most difficult but most important processes from perspectives of project management. These processes involve implementation of a widerange of planning methods used by different organizations with various levels of planning knowledge. The planning methods for scheduling can be classified as traditional methods (e.g. line of balance, Gantt chart and critical path) and modern methods (e.g. last planner and critical chain). Over time these methods had advanced from paper based to computer based. However, some project planners still prefer using the traditional methods despite other new alternatives. Users of those methods have different perspectives about the efficiency and effectiveness of the different planning methods used to manage different projects. Evidences from the secondary data found from extensive literatures have been used to assess the planning and scheduling methods mentioned above. A taxonomy describing each of the method in terms of their theories, key features, application areas, benefits and limitations is presented. The preliminary outcome of this paper may provide a tool to aid organizations in selecting and prioritizing the most appropriate methods to be developed and implemented in planning and scheduling of their projects. It also initializes a theoretical base for more rapid taxonomy studies on the use of different planning and scheduling approaches. As an overall, the present paper reminds practitioners of common ground about its important insights on how such taxonomy studies have potential to make scope of those methods and tools clearer, especially when they compare among them within the same application contexts.
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| 4. |
- Azouri, Kristian, et al.
(författare)
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Hotellrapport Stockholm
- 2011
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Rapport (populärvet., debatt m.m.)abstract
- Stockholm är Sveriges största stad och marknadsför sig som ”The Capital of Scandinavia”. De flesta resenärer som besöker Sverige åker till just Stockholm. År 2010 nådde Stockholms län 10 miljoner kommersiella övernattningar. Det är lätt att ta sig till Stockholm med både flyg, tåg, båt, bil och buss. Stockholm har ett brett utbud av kongress- och mässanläggningar. År 2009 var Stockholm den sjunde mest populära staden i världen att förlägga kongresser på. I dagsläget är Sverige på väg ur den lågkonjunktur som startade år 2008. Sveriges BNP och valuta är på väg att stabiliseras och stärkas. Regeringen har även lagt in ett förslag om att sänka tjänstemomsen inom hotell- och restaurangbranschen. I denna rapport har vi valt att avgränsa oss till ett eget utvalt område inom Stockholm. Detta område innefattar 143 hotell med 20 054 hotellrum.De prognoser vi gjort gällande staden Stockholm och segmenten affärsresenärer och fritidsresenärer pekar på en ökning av besökare till staden. Detta kommer resultera i att hotellens beläggning, snittpris och RevPAR kommer att öka framtill år 2013. Efter år 2013 tror vi att segmentet affärsresenärer kommer att minska något procentuellt och kurvan för belagda nätter kommer att stabiliseras. Dock tror vi att segmentet fritidsresenärer kommer att öka procentuellt efter år 2013 och antalet belagda hotellrum kommer att successivt öka mellan åren 2011 – 2015. Vi tror att snittpris och RevPAR kommer att sjunka på grund av att en fritidsresenär generellt sätt inte betalar lika mycket för ett hotellrum som en affärsresenär gör.
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| 5. |
- Berndt, Sonja I., et al.
(författare)
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Tidskriftsartikel (refereegranskat)abstract
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
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| 6. |
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| 7. |
- Bertelsen, Niels Haldor, et al.
(författare)
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National and International Benchmarking - CREDIT Report 6
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report summarises the work undertaken in the CREDIT project and proposals for how to implement the CREDIT framework. It is the final part of the Nordic/Baltic project CREDIT: Construction and Real Estate – Developing Indicators for Transparency. The report presents the objectives and the research model for CREDIT followed by a summary of the results of CREDIT Reports 2, 3, 4 and 5. The conclusive part of the report presents national recommendations of how to implement the CREDIT framework in the Nordic/Baltic countries Denmark, Finland, Norway, Sweden, Iceland, Estonia and Lithuania.
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| 8. |
- Eriksson, Per-Erik, et al.
(författare)
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Managing short-term efficiency and long-term development through industrialized construction
- 2014
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Ingår i: Construction Management and Economics. - Abingdon, Oxon : Informa UK Limited. - 0144-6193 .- 1466-433X. ; 32:1-2, s. 97-108
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Tidskriftsartikel (refereegranskat)abstract
- There is a strong need for a productive and innovative infrastructure sector because of its monetary value and importance for the development of a sustainable society. An increased level of industrialization is often proposed as a way to improve efficiency and productivity in construction projects. In prior literature on industrialized construction, there are however neither many studies addressing more long-term aspects of innovation and sustainability nor studies within the infrastructure context. Organizational theory suggests that firms need to be ambidextrous and focus on both long-term exploration of new knowledge and technologies and short-term exploitation of current knowledge and technologies, in order to achieve sustainable development. Therefore, an investigation of how both short-term exploitative performance objectives and long-term explorative development can be addressed when implementing industrialized construction in infrastructure projects was conducted. A case study consisting of four infrastructure projects shows that the main drivers for increased industrialization are of an exploitative nature, focusing on cost savings and increased productivity through more efficient processes. The main barriers to increased industrialization are however related to both explorative and exploitative activities. Hence, by managing the identified barriers and explicitly addressing both exploitation and exploration, industrialized construction can improve both short-term efficiency and long-term innovation and sustainability.
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| 9. |
- Hansson, Bengt, et al.
(författare)
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Project Assessments in Construction and Real Estate - Analysing management of end-user needs and ensuring performance in the building life cycle. CREDIT Report 4
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this report a generic model for the capture and assessment of end-user requirements and needs, the CREDIT carpenter model, has been developed. The main determinants of the model is the need for the project organisation (including the facilities management organisation) to ensure a thorough understanding of the end-user requirements and needs as well as an assessment through out the project process. The end-users and the project organisation are often working in two different value chains. This, among other things, means that they may not share a common understanding of the process. Apart from just assessing to what extent the requirements and needs has been achieved it is important to assess the process of accomplishing the desired result. This way it is possible to learn from what has worked well and what has not. There is some variation in what and how it is being assessed depending on what type of building it is. Assessments on housing are more inclined to focus on softer aspects, for example perception etc. In the other cases there are, generally, a more technical perspective. It may be an affect of how knowledgeable the users are. In regard to housing the users have possible less experience of construction and communicating their needs than in the case of offices etc. There is also a notable difference between approaches and interest on what to assess in the different countries. Sweden has a much more soft approach and an ambition of getting as many as possible to understand what is being assessed and for what reasons while Finland has a much more technical and measurable approach. The clients, naturally, play a large part in the construction process, also when it come to capturing and transferring the requirements and needs of the end-users. It is mainly the clients that initiate it. Maybe more surprisingly, they do perform a lot of the work themselves as well. Designers play an important role as do known end-users as well. During the project it is mainly the client that initiates the assessments, but the actors of the project process, designers and producers that perform it. Evaluating the degree of fulfilling the requirements and needs as well as assessing the process to enable learning is again mainly a client action both initiating and performing, the rest of the actors do not engage to any larger degree. The processes from begin of the brief to the end of construction have well developed routines as a part of the project management system. These routines are good enough to successfully fulfil the studied project and the control of the process in order to get internal efficiency in the short run perspective. But there is almost no case that shows any assessment tool that support feedback, the knowledge development and the innovation process which is important in the long-run perspective. The missing feedback is marked in the carpenter model. Found in the study there are two examples of tools that together may to some extent overrun this issue. Building Information Models have the potential of acting as an information carrier within a project, storing all types of information needed for assessing a number of different aspects. The main issue is to get the right information and presenting it in a way suitable for the target group. This is done in the case of Falk in Skanska (in Norway). It is a system gathering and presenting a multitude of KPIs, from a number of different systems, in an easy to understand layout.
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| 10. |
- Huovila, Pekka, et al.
(författare)
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National and International Benchmarking - CREDIT Report 5.
- 2010
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report summarizes findings and recommendations from 24 case studies from seven participating countries addressing performance indicator benchmarking at a sectoral, national or international scale. Their distribution in scope is: – benchmarking systems and indicators (4 case studies) – offices (7 case studies) – housing (6 case studies) – school and nursery (4 case studies) – shopping centres (3 case studies). In addition, actual performance benchmarking was done between six Finnish and Norwegian office buildings using CREDIT Key Performance Indicators and a web-based benchmarking tool, developed in CREDIT for that purpose. Some good benchmarking practices exist already at a national and international level. They focus on process issues, investment aspects and environmental properties. These existing schemes contribute to the CREDIT framework, but don't cover well the performance dimension. There isn't yet any commonly agreed European Key Performance Indicator system, or building and real estate performance indicator standard. CREDIT made a contribution to their development from the Nordic/Baltic perspective. It also provided valuable input from the performance and social sustainability point of view to existing economic and environmental oriented schemes that are continuously updated and amended. CREDIT made progress in performance indicator framework and actual performance indicators and tools, some of which were already tested in the case studies. Understanding on existing benchmarking schemes is also improved. The results of CREDIT WP6 performance indicator benchmarking at a sectoral, national or international scale can be exploited in number of ways, such as – the front runner companies adopt the core performance indicators in their practices and influence in forming their use a sector based practice – further development of standardization, tool development (IFCs), benchmarking schemes and rating systems makes use of the results.
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