SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wiggins Kerri L.) srt2:(2014)"

Sökning: WFRF:(Wiggins Kerri L.) > (2014)

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Postmus, Iris, et al. (författare)
  • Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
  • 2014
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5
  • Tidskriftsartikel (refereegranskat)abstract
    • Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.
  •  
2.
  • Bruzelius, Maria, et al. (författare)
  • Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism
  • 2014
  • Ingår i: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 134:2, s. 426-432
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n = 2753) from Sweden. Materials and Methods: 39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression. Results: Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n = 7181). Conclusions: It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.
  •  
3.
  • Traylor, Matthew, et al. (författare)
  • A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach.
  • 2014
  • Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 10:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect associations. As prevalence rates in IS are markedly affected by age, and younger onset cases may have higher genetic predisposition, we investigated whether an age-at-onset informed approach could detect novel associations with IS and its subtypes; cardioembolic (CE), large artery atherosclerosis (LAA) and small vessel disease (SVD) in 6,778 cases of European ancestry and 12,095 ancestry-matched controls. Regression analysis to identify SNP associations was performed on posterior liabilities after conditioning on age-at-onset and affection status. We sought further evidence of an association with LAA in 1,881 cases and 50,817 controls, and examined mRNA expression levels of the nearby genes in atherosclerotic carotid artery plaques. Secondly, we performed permutation analyses to evaluate the extent to which age-at-onset informed analysis improves significance for novel loci. We identified a novel association with an MMP12 locus in LAA (rs660599; p = 2.5×10-7), with independent replication in a second population (p = 0.0048, OR(95% CI) = 1.18(1.05-1.32); meta-analysis p = 2.6×10-8). The nearby gene, MMP12, was significantly overexpressed in carotid plaques compared to atherosclerosis-free control arteries (p = 1.2×10-15; fold change = 335.6). Permutation analyses demonstrated improved significance for associations when accounting for age-at-onset in all four stroke phenotypes (p<0.001). Our results show that a covariate-informed design, by adjusting for age-at-onset of stroke, can detect variants not identified by conventional GWAS.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3
Typ av publikation
tidskriftsartikel (3)
Typ av innehåll
refereegranskat (3)
Författare/redaktör
Rothwell, Peter M. (1)
Kittner, Steven J. (1)
Meschia, James F (1)
Groop, Leif (1)
Ahlqvist, Emma (1)
Sattar, Naveed (1)
visa fler...
O'Brien, Eoin (1)
Sundström, Anders (1)
Syvänen, Ann-Christi ... (1)
Odeberg, Jacob (1)
Dichgans, Martin (1)
Rosand, Jonathan (1)
McCarthy, Mark I (1)
Tregouet, David Alex ... (1)
Ridker, Paul M. (1)
Chasman, Daniel I. (1)
Chu, Audrey Y (1)
Hamsten, Anders (1)
Zhao, Wei (1)
Saleheen, Danish (1)
Raitoharju, Emma (1)
Lehtimäki, Terho (1)
Colhoun, Helen M. (1)
Rotter, Jerome I. (1)
Lindgren, Arne (1)
Nyberg, Fredrik, 196 ... (1)
Sharma, Pankaj (1)
Caulfield, Mark J. (1)
Munroe, Patricia B. (1)
Palmer, Colin N. A. (1)
Devan, William J. (1)
Slowik, Agnieszka (1)
Vasan, Ramachandran ... (1)
Ohrvik, John (1)
Kieler, Helle (1)
Rivadeneira, Fernand ... (1)
Eiriksdottir, Gudny (1)
Harris, Tamara B (1)
Heckbert, Susan R (1)
Kritchevsky, Stephen ... (1)
Liu, Yongmei (1)
Lumley, Thomas (1)
Hofman, Albert (1)
Uitterlinden, André ... (1)
Psaty, Bruce M (1)
Gudnason, Vilmundur (1)
Franco, Oscar H. (1)
O'Donnell, Christoph ... (1)
Tardif, Jean-Claude (1)
de Bakker, Paul I. W ... (1)
visa färre...
Lärosäte
Lunds universitet (2)
Göteborgs universitet (1)
Kungliga Tekniska Högskolan (1)
Uppsala universitet (1)
Karolinska Institutet (1)
Språk
Engelska (3)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (3)
År
2014 (3)Ta bort avgränsningen

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy