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Sufficient levels o...
Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study
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- Verlaan, Sjors (författare)
- Nutricia Adv Med Nutr, Nutricia Res, Utrecht, Netherlands.;Vrije Univ Amsterdam Med Ctr, Sect Gerontol & Geriatr, Dept Internal Med, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
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- Maier, Andrea B. (författare)
- Vrije Univ Amsterdam, MOVE Res Inst Amsterdam, Dept Human Movement Sci, Amsterdam, Netherlands.;Univ Melbourne, Royal Melbourne Hosp, Dept Med & Aged Care, Melbourne, Vic, Australia.
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- Bauer, Juergen M. (författare)
- Carl von Ossietzky Univ Oldenburg, Dept Geriatr Med, Oldenburg, Germany.
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- Bautmans, Ivan (författare)
- Vrije Univ Brussel, Frailty Ageing Res Grp FRIA, Brussels, Belgium.
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- Brandt, Kirsten (författare)
- Newcastle Univ, Inst Ageing, Sch Agr Food & Rural Dev, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
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- Donini, Lorenzo M. (författare)
- Sapienza Univ Rome, Dept Expt Med, Sect Med Pathophysiol Endocrinol & Human Nutr, Rome, Italy.
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- Maggio, Marcello (författare)
- Univ Parma, Dept Clin & Expt Med, Sect Geriatr, Parma, Italy.
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- McMurdo, Marion E. T. (författare)
- Univ Dundee, Ninewells Hosp & Med Sch, Ageing & Hlth, Dundee, Scotland.
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- Mets, Tony (författare)
- Vrije Univ Brussel, Frailty Ageing Res Grp FRIA, Brussels, Belgium.
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- Seal, Chris (författare)
- Newcastle Univ, Inst Ageing, Sch Agr Food & Rural Dev, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
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- Wijers, Sander L. J. (författare)
- Nutricia Adv Med Nutr, Nutricia Res, Utrecht, Netherlands.
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- Sieber, Cornel (författare)
- Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany.
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- Boirie, Yves (författare)
- CHU Clermont Ferrand, Serv Nutr Clin, F-63003 Clermont Ferrand, France.;Univ Auvergne, Clermont Univ, Unite Nutr Humaine, BP 10448, F-63000 Clermont Ferrand, France.
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- Cederholm, Tommy (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Geriatrik
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Nutricia Adv Med Nutr, Nutricia Res, Utrecht, Netherlands;Vrije Univ Amsterdam Med Ctr, Sect Gerontol & Geriatr, Dept Internal Med, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands. Vrije Univ Amsterdam, MOVE Res Inst Amsterdam, Dept Human Movement Sci, Amsterdam, Netherlands.;Univ Melbourne, Royal Melbourne Hosp, Dept Med & Aged Care, Melbourne, Vic, Australia. (creator_code:org_t)
- Elsevier, 2018
- 2018
- Engelska.
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Ingår i: Clinical Nutrition. - : Elsevier. - 0261-5614 .- 1532-1983. ; 37:2, s. 551-557
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http://www.clinicaln...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status. Objective: To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention. Methods and design: Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs. Results: At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h(2)), and relative appendicular muscle mass (aMM/body weight x 100%) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test. Conclusions: Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the "minimum" for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss. (C) 2017 The Author(s). Published by Elsevier Ltd.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Oral nutritional supplement
- Sarcopenia
- 25-Hydroxyvitamin D
- Protein intake
- Muscle mass
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Verlaan, Sjors
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Maier, Andrea B.
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Bauer, Juergen M ...
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Bautmans, Ivan
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Brandt, Kirsten
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Donini, Lorenzo ...
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visa fler...
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Maggio, Marcello
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McMurdo, Marion ...
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Mets, Tony
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Seal, Chris
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Wijers, Sander L ...
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Sieber, Cornel
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Boirie, Yves
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Cederholm, Tommy
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