| 1. |
- Breimer, Michael, 1951, et al.
(författare)
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The specific glycosphingolipid composition of human ureteral epithelial cells.
- 1985
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Ingår i: Journal of biochemistry. - 0021-924X. ; 98:5, s. 1169-80
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Tidskriftsartikel (refereegranskat)abstract
- Total non-acid and acid glycolipid fractions were isolated from epithelial cell scrapings and the non-epithelial residue of a human upper ureter. The glycolipid fractions were structurally characterized as total mixtures by thin-layer chromatography, mass spectrometry, and proton NMR spectroscopy. Selected structural information was also obtained on binding of monoclonal antibodies and bacteria to the thin-layer chromatograms. The major epithelial cell glycolipids were Glc beta 1-1ceramide (75%), dihexosylceramide (10%) and NeuAcLacceramide (10%). In addition, 8 minor glycolipids belonging to the blood group P, Lewis and ABO systems were identified. The major glycolipids of the non-epithelial residues were mono- and dihexosylceramides together with globotriaosyl- and globotetraosylceramides. The epithelial mono- and diglycosylceramide compounds had an unusual ceramide composition with mainly C18 and C20 trihydroxy long chain bases in combination with C22-C24 hydroxy fatty acids in contrast to the non-epithelial glycolipids which contained mainly C18 dihydroxy long chain bases in combination with C16-C24 non-hydroxy fatty acids.
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| 2. |
- Klintman, Mikael, et al.
(författare)
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Academia and society in collaborative knowledge production towards urban sustainability : several schemes—three common crossroads
- 2022
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Ingår i: Environment, Development and Sustainability. - : Springer Science and Business Media LLC. - 1387-585X .- 1573-2975.
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Tidskriftsartikel (refereegranskat)abstract
- Arrangements for collaboration in knowledge production across academia, government, non-governmental organisations, and corporations have several names, such as citizen-science, community-based participatory research, engaged research and hybrid forums. The multiplicity of schemes does not lie only in the high number of names for various versions of collaborative knowledge production. Different scholars also use concepts in multiple ways, depending on their individual choices, mother disciplines, and the problem area in which collaboration occurs. At the same time, there is a lack of analytical tools that address the full range of collaborative research schemes and provide a systematic set of questions to learn about the schemes, challenges, and opportunities. Based on our review of academic journal articles highlighting collaborative research schemes, this paper aims to analyse three parameters which it is fair to say that virtually all arrangements of collaborative knowledge production ought to consider when making decisions, parameters that are often partially missed or misunderstood: (A) epistemic-procedural, (B) exclusive-inclusive and (C) aggregative-integrative. By examining the three parameters, their political theory origins, and how they connect to and challenge existing schemes of knowledge collaboration, we provide analytical tools that could facilitate processes of developing and scrutinising arrangements of collaborative research.
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| 3. |
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| 4. |
- de Lauzon, Blandine, et al.
(författare)
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The Three-Factor Eating Questionnaire-R18 is able to distinguish among different eating patterns in a general population.
- 2004
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Ingår i: The Journal of nutrition. - 0022-3166. ; 134:9, s. 2372-80
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Tidskriftsartikel (refereegranskat)abstract
- A revised version of the Three-Factor Eating Questionnaire (TFEQ) was developed in an obese population, but its applicability to the general population was not assessed. We aimed to define the relationship between eating behavior and reported food intake. This was a cross-sectional study of 529 middle-aged adults and 358 teenagers and young adults recruited on a geographical basis. The TFEQ-R18 measures 3 aspects of eating behavior: cognitive restraint (CR), uncontrolled eating (UE), and emotional eating. Reported food intake was calculated from a food frequency questionnaire. Girls who scored higher on restrained eating had a lower energy intake than the other girls (9164 kJ vs. 13,163 kJ, P < 0.001). In adult men, energy intake increased with UE (9663 kJ vs. 11,029 kJ in the lower and higher UE tertiles, respectively, P < 0.05). When specific food groups were analyzed, higher CR was positively associated in adults with healthy food groups like green vegetables [OR = 1.92 (0.68-2.44)] and negatively associated with French fries [OR = 0.35 (0.22-0.57)] and sugar [OR = 0.38 (0.23-0.61)]. Energy-dense foods, such as fat, were positively associated with UE [OR = 2.28 (1.46-3.57) for dietary fat]. Finally, emotional eaters had a higher snacking food intake. In teenagers and young adults, most associations were seen with CR. Converse to observations in adults, teenagers and young adults who exhibited a high cognitive restraint reported consumption of fewer energy-dense foods rather than more "healthy foods." The TFEQ-R18 was therefore able to distinguish among different eating patterns in our sample of a French general population.
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| 5. |
- Klugman, Sofia, et al.
(författare)
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A Scandinavian chemical wood-pulp mill : Part 1. Energy audit aiming at efficiency measures
- 2007
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Ingår i: Applied Energy. - : Elsevier BV. - 0306-2619 .- 1872-9118. ; 84:3, s. 326-339
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Tidskriftsartikel (refereegranskat)abstract
- A Swedish wood-pulp mill is surveyed in terms of energy supply and use in order to determine the energy-saving potential. Conservation measures are of increasing interest to Swedish industry, as energy prices have continued to rise in recent years. The electricity price particularly increased after the deregulation of the Scandinavian electricity market in 1996. The deregulation expanded to all of the EU in July 2004, which may increase the Swedish electricity price further until it reaches the generally higher European price level. Furthermore, oil prices have increased and the emissions trading scheme for CO2 adds to the incentive to reduce oil consumption. The energy system at the surveyed pulp mill is described in terms of electricity and process heat production and use. The total energy-saving potential is estimated and some saving points are identified. The heat that today is wasted at the mill has been surveyed in order to find potential for heat integration or heat export. The result shows that the mill probably could become self-sufficient in electricity. Particularly important in that endeavor is updating old pumps.
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| 6. |
- Panchenko, Polina E., et al.
(författare)
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Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice
- 2016
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Ingår i: Clinical Epigenetics. - : Springer Science and Business Media LLC. - 1868-7083 .- 1868-7075. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:Maternal obesity impacts fetal growth and pregnancy outcomes. To counteract the deleterious effects of obesity on fertility and pregnancy issue, preconceptional weight loss is recommended to obese women. Whether this weight loss is beneficial/detrimental for offspring remains poorly explored. Epigenetic mechanisms could be affected by maternal weight changes, perturbing expression of key developmental genes in the placenta or fetus. Our aim was to investigate the effects of chronic maternal obesity on feto-placental growth along with the underlying epigenetic mechanisms. We also tested whether preconceptional weight loss could alleviate these effects.RESULTS:Female mice were fed either a control diet (CTRL group), a high-fat diet (obese (OB) group), or a high-fat diet switched to a control diet 2 months before conception (weight loss (WL) group). At mating, OB females presented an obese phenotype while WL females normalized metabolic parameters. At embryonic day 18.5 (E18.5), fetuses from OB females presented fetal growth restriction (FGR; -13 %) and 28 % of the fetuses were small for gestational age (SGA). Fetuses from WL females normalized this phenotype. The expression of 60 epigenetic machinery genes and 32 metabolic genes was measured in the fetal liver, placental labyrinth, and junctional zone. We revealed 23 genes altered by maternal weight trajectories in at least one of three tissues. The fetal liver and placental labyrinth were more responsive to maternal obesity than junctional zone. One third (18/60) of the epigenetic machinery genes were differentially expressed between at least two maternal groups. Interestingly, genes involved in the histone acetylation pathway were particularly altered (13/18). In OB group, lysine acetyltransferases and Bromodomain-containing protein 2 were upregulated, while most histone deacetylases were downregulated. In WL group, the expression of only a subset of these genes was normalized.CONCLUSIONS:This study highlights the high sensitivity of the epigenetic machinery gene expression, and particularly the histone acetylation pathway, to maternal obesity. These obesity-induced transcriptional changes could alter the placental and the hepatic epigenome, leading to FGR. Preconceptional weight loss appears beneficial to fetal growth, but some effects of previous obesity were retained in offspring phenotype.
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