| 1. |
- Pfaller, M.A., et al.
(författare)
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Twelve years of fluconazole in clinical practice : Global-trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida
- 2004
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Ingår i: Clinical Microbiology and Infection. - : Elsevier BV. - 1198-743X .- 1469-0691. ; 10:SUPPL. 1, s. 11-23
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Tidskriftsartikel (refereegranskat)abstract
- We determined the species distribution and in-vitro susceptibility of 6082 bloodstream infection (BSI) isolates of Candida spp. collected from 250 medical centres in 32 nations over a 10-year period from 1992 through 2001. The species included 3401 C. albicans, 984 C. glabrata, 796 C. parapsilosis, 585 C. tropicalis, 153 C. krusei, 67 C. lusitaniae, 48 C. guilliermondii, 10 C. famata, 10 C. kefyr, six C. pelliculosa, five C. rugosa, four C. lipolytica, three C. dubliniensis, three C. inconspicua, two C. sake and one isolate each of C. lambica, C. norvegensis and C. zeylanoides. Minimum inhibitory concentration determinations were made using the National Committee for Clinical Laboratory Standards reference broth microdilution method. Variation in the rank order and frequency of the different species of Candida was observed over time and by geographic area. The proportion of BSI due to C. albicans and C. glabrata increased and C. parapsilosis decreased over time in Canada, the USA and Europe. C. glabrata was an infrequent cause of BSI in Latin America and the Asia-Pacific region. Very little variation in fluconazole susceptibility was observed among isolates of C. albicans, C. tropicalis and C. parapsilosis. These species accounted for 78% of all BSI and remained highly susceptible (91-100% susceptible) to fluconazole from 1992 to 2001 irrespective of geographic origin. The prevalence of fluconazole resistance among C. glabrata isolates was variable both over time and among the various countries and regions. Resistance to fluconazole among C. glabrata isolates was greatest in the USA and varied by US census region (range 0-23%). These observations are generally encouraging relative to the sustained usefulness of fluconazole as a systemically active antifungal agent for the treatment of candida BSI. © 2004 Copyright by the European Society of Clinical Microbiology and Infectious Diseases.
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| 2. |
- Hillier, Ladeana W, et al.
(författare)
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Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
- 2004
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Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 432:7018, s. 695-716
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Tidskriftsartikel (refereegranskat)abstract
- We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
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| 3. |
- Beral, V, et al.
(författare)
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Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58515 women with breast cancer and 95067 women without the disease
- 2002
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Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 87, s. 1234-45
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Tidskriftsartikel (refereegranskat)abstract
- Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58515 women with invasive breast cancer and 95067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19 - 1.45, P < 0.00001) for an intake of 35 - 44 g per day alcohol, and 1.46 (1.33 - 1.61, P < 0.00001) for greater than or equal to 45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P<0.00001) for each additional 10 g per day intake of alcohol, i.e. for each extra unit or drink of alcohol consumed on a daily basis. This increase was the same in ever-smokers and never-smokers (7.1 % per 10 g per day, P < 0.00001, in each group). By contrast, the relationship between smoking and breast cancer was substantially confounded by the effect of alcohol. When analyses were restricted to 22 255 women with breast cancer and 40 832 controls who reported drinking no alcohol, smoking was not associated with breast cancer (compared to never-smokers, relative risk for ever-smokers= 1.03, 95% CI 0.98 - 1.07, and for current smokers=0.99, 0.92 - 1.05). The results for alcohol and for tobacco did not vary substantially across studies, study designs, or according to 15 personal characteristics of the women; nor were the findings materially confounded by any of these factors. If the observed relationship for alcohol is causal, these results suggest that about 4% of the breast cancers in developed countries are attributable to alcohol. In developing countries, where alcohol consumption among controls averaged only 0.4 g per day, alcohol would have a negligible effect on the incidence of breast cancer. In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis and cancers of the mouth, larynx, oesophagus and liver. (C) 2002 Cancer Research UK.
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| 4. |
- Charlton, D. G., et al.
(författare)
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System tests of radiation hard optical links for the ATLAS semiconductor tracker
- 2000
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 443:03-feb, s. 430-446
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Tidskriftsartikel (refereegranskat)abstract
- A prototype optical data and Timing Trigger and Control transmission system based on LEDs and PIN-diodes has been constructed. The system would be suitable in terms of radiation hardness and radiation length for use in the ATLAS SemiConductor Tracker. Bit error rate measurements were performed for the data links and for the links distributing the Timing, Trigger and Control data from the counting room to the front-end modules. The effects of cross-talk between the emitters and receivers were investigated. The advantages of using Vertical Cavity Surface Emitting Lasers (VCSELs) instead of LEDs are discussed.
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| 5. |
- Mahout, G., et al.
(författare)
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Irradiation studies of multimode optical fibres for use in ATLAS front-end links
- 2000
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 446:3, s. 426-434
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Tidskriftsartikel (refereegranskat)abstract
- The radiation tolerance of three multimode optical fibres has been investigated to establish their suitability for the use in the front-end data links of the ATLAS experiment. Both gamma and neutron irradiation studies are reported. A step-index fibre with a pure silica core showed an induced attenuation of similar to 0.05 dB/m at 330 kGy(Si) and 1 x 10(15) n(1 MeV Si)/cm(2) and is suitable for use with the inner detector links which operate at 40-80 Mb/s. A graded-index fibre with a predominantly germanium-doped core exhibits an induced attenuation of similar to 0.1 dB/m at 800 Gy(Si) and 2 x 10(13) n(1 MeV Si)/cm(2) and is suitable for the calorimeter links which operate at 1.6 Gb/s. Measurements of the dose rate dependence of the induced attenuation indicate that the attenuation in ATLAS will be lower.
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| 6. |
- Wilson, A. N., et al.
(författare)
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High-spin structures and alignment properties in Ce-126
- 2001
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 6305:5
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in Ce-126 have been observed with the GAMMASPHERE gamma -ray detector array, used in conjunction with the MICROBALL charged-particle detector. The reaction Zn-64(Zn-64, xpn alpha) (beam energy 260 MeV) was used to populate a wide range of nuclei in the neutron-deficient region with A approximate to 120. Ce-126 was populated via the 2p evaporation channel. The three previously observed bands have been extended to higher spins and some other structures have been identified. The yrast band shows evidence of a delayed neutron alignment occurring at a rotational frequency omega approximate to0.5 MeV/(h) over bar as observed in the neighboring odd-A nucleus Pr-127. One of the two excited bands shows evidence for a similar crossing at a slightly lower frequency and also exhibits a sudden gain in alignment at omega =0.57 MeV/(h) over bar. The third band may involve the coupling of a gamma -vibrational state. All three rotational bands are discussed in terms of standard and extended cranked shell model calculations.
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| 7. |
- Wilson, A. N., et al.
(författare)
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Magnetic dipole bands in 190Hg : First evidence of excitations across the Z = 82 sub-shell in Hg nuclei
- 2001
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Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - 0370-2693. ; 505:1-4, s. 6-14
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Tidskriftsartikel (refereegranskat)abstract
- An experiment aimed at studying high-spin states in 190Hg was performed with the Eurogam II array. The data have revealed the presence of cascades of magnetic dipole transitions with some unexpected properties. Unlike the MI bands previously observed in the heavier Hg isotopes, these structures have extremely large B(M1)/B(E2) ratios, The observation of a third dipole band with much lower B(M1)/B(E2) values in the same spin/excitation energy regime suggests that the bands may represent configurations occurring in different minima in the potential energy surface. Configuration-dependent Cranked Nilsson-Strutinsky calculations predict the presence of a minimum in the nuclear potential energy surface at a deformation of ε ≅ 0.2, γ ≅ -90°, occurring when a proton is excited across the Z = 82 shell-gap into an h9/2 orbital. It is suggested that the bands exhibiting anomalously large B(M1)/B(E2) ratios may be associated with this minimum.
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| 8. |
- Yu, C. H., et al.
(författare)
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Superdeformed and Highly Deformed Bands in 65Zn and Neutron-proton Interactions in Zn Isotopes
- 2000
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- Superdeformed and highly deformed rotational bands were established in Zn-65 using the Ca-40(Si-29,4p)Zn-65 reaction, and averaged quadrupole moments were measured for two of these bands. The configurations of these bands were assigned based on Hartree-Fock calculations. One of the three bands exhibits at low (h) over bar omega a rise in the J((2)) dynamic moments of inertia that is similar to the alignment gain observed in Zn-60. A comparison of the rotational band configurations and their J((2)) moments of inertia for light Zn isotopes suggests that the rise in J((2)) is most likely caused by np interactions associated with the valence protons and neutrons occupying the g(9/2) intruder orbits.
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| 9. |
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Highlights from the first year of Odin observations
- 2003
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L39-L46
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Tidskriftsartikel (refereegranskat)abstract
- Key Odin operational and instrumental features and highlights from our sub-millimetre and millimetre wave observations of H2O, H218O, NH3, 15NH3 and O2 are presented, with some insights into accompanying Odin Letters in this A&A issue. We focus on new results where Odin's high angular resolution, high frequency resolution, large spectrometer bandwidths, high sensitivity or/and frequency tuning capability are crucial: H2O mapping of the Orion KL, W3, DR21, S140 regions, and four comets; H2O observations of Galactic Centre sources, of shock enhanced H2O towards the SNR IC443, and of the candidate infall source IRAS 16293-2422; H218O detections in Orion KL and in comet Ikeya-Zhang; sub-mm detections of NH3 in Orion KL (outflow, ambient cloud and bar) and ρ Oph, and very recently, of 15NH3 in~Orion KL. Simultaneous sensitive searches for the 119 GHz line of O2 have resulted in very low abundance limits, which are difficult to accomodate in chemical models. We also demonstrate, by means of a quantitative comparison of Orion KL H2O results, that the Odin and SWAS observational data sets are very consistently calibrated. Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes), and the Centre National d'études Spatiales (CNES, France). The Swedish Space Corporation (SSC) has been the prime industrial contractor, and is also responsible for the satellite operation from its Odin Mission Control Centre at SSC in Solna and its Odin Control Centre at ESRANGE near Kiruna in northern Sweden. See also the SNSB Odin web page: http://www.snsb.se/eng_odin_intro.shtml
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| 10. |
- Kelsall, N. S., et al.
(författare)
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Testing mean-field models near the N=Z line : gamma-ray spectroscopy of the T-z=1/2 nucleus Kr-73
- 2002
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 65:4
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in the N=Z+1 nucleus Kr-73 have been investigated using the Ca-40(Ar-36,2pn) and Ca-40(Ca-40,alpha2pn) reactions at 145 and 160 MeV, respectively. gamma rays were detected using the Gammasphere array and events were recorded in coincidence with charged-particle and neutron detectors. The three previously observed bands were extended to high spin, and a new unfavored positive-parity band has been observed. The alignment characteristics and decay properties of the bands are all consistent with large-deformation prolate rotation, with no clear evidence for oblate bands or shape coexistence. This is quite different from neighboring Kr-72,Kr-74, indicating a strong shape-stabilizing role for the valence neutron. The experimental results are compared to extended total Routhian surface, cranked Nilsson Strutinsky, and cranked relativistic mean-field calculations. The results suggest that the paired calculations lack some important physics. Neutron-proton correlations may be the missing ingredient. There is also evidence for an unusual band crossing in the negative-parity bands, which may indicate the presence of T=0 pairing correlations. At high spin all the models can reproduce the experimental data.
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