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- Ren, WC, et al.
(författare)
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Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma
- 2018
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 131:24, s. 2670-2681
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Tidskriftsartikel (refereegranskat)abstract
- Hepatitis B virus (HBV) infection is endemic in some parts of Asia, Africa, and South America and remains to be a significant public health problem in these areas. It is known as a leading risk factor for the development of hepatocellular carcinoma, but epidemiological studies have also shown that the infection may increase the incidence of several types of B-cell lymphoma. Here, by characterizing altogether 275 Chinese diffuse large B-cell lymphoma (DLBCL) patients, we showed that patients with concomitant HBV infection (surface antigen positive [HBsAg+]) are characterized by a younger age, a more advanced disease stage at diagnosis, and reduced overall survival. Furthermore, by whole-genome/exome sequencing of 96 tumors and the respective peripheral blood samples and targeted sequencing of 179 tumors from these patients, we observed an enhanced rate of mutagenesis and a distinct set of mutation targets in HBsAg+ DLBCL genomes, which could be partially explained by the activities of APOBEC and activation-induced cytidine deaminase. By transcriptome analysis, we further showed that the HBV-associated gene expression signature is contributed by the enrichment of genes regulated by BCL6, FOXO1, and ZFP36L1. Finally, by analysis of immunoglobulin heavy chain gene sequences, we showed that an antigen-independent mechanism, rather than a chronic antigenic simulation model, is favored in HBV-related lymphomagenesis. Taken together, we present the first comprehensive genomic and transcriptomic study that suggests a link between HBV infection and B-cell malignancy. The genetic alterations identified in this study may also provide opportunities for development of novel therapeutic strategies.
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- Ibrahim, Muhammad Asim, 1980-, et al.
(författare)
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Mitigating the emissions released from spontaneous fires at biomass storages : A footstep towards sustainability
- 2015
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Ingår i: 23rd European Biomass Conference and Exhibition, Vienna, Austria, 1-4 June 2015. - 9788889407516 ; , s. 1550-1557
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Konferensbidrag (refereegranskat)abstract
- Fires at the material storages sites of manucipal and industrial sectors are a major environmental risk and have increased significantly. Toxic emissions released from such open fires have severe environmental and health consequences. Considering that it is not possible to install any unit operation to control the emissions released from such open fires, the possibilities to employ natural vegetation to act as a sink for aerosol particles released from open fires was investigated. A series of tests was conducted in a controlled wind tunnel environment. Smoke was generated in a smoke-aerosol generator and measurements of smoke concentrations upwind and downwind of “green filter packs” (vegetation filters) were made. Measurements involved laser-based particle counters, two-stage Nuclepore filter systems, and Solid Phase Microextraction (SPME) techniques followed by Gas Chromatography-Mass Spectrometry (GC-MS). The main objective of the work was to illustrate ways to design experiments that can assist in the study of vegetation as “pollution screens”. Our observations and findings imply that several refinements to the experimental design will be needed, including with respect to methods for assessing the distribution of particle number and mass as a function of particle size.
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