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Sökning: WFRF:(Winberg J.) > (2000-2004)

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  • Balkenius, Christian, et al. (författare)
  • Cognitive modeling with context sensitive reinforcement learning
  • 2004
  • Ingår i: Proceedings of AILS 04 ( Report / Lund Institute of Technology, Lund University ; 151). - 1650-1276. ; , s. 10-19
  • Konferensbidrag (refereegranskat)abstract
    • We describe how a standard reinforcement learning algorithm can be changed to include a second contextual input that is used to modulate the learning in the original algorithm. The new algorithm takes the context into account during relearning when the previously learned actions are no longer valid. The algorithm was tested on a number of cognitive experiment and shown to reproduce the learning in both a task switching test and in the Wisconsin Card Sorting Test. In addition, the algorithm was able to learn a context sensitive categorization of objects in the Labov experiment.
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  • Isaguliants, MG, et al. (författare)
  • DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge
  • 2000
  • Ingår i: Intervirology. - : S. Karger AG. - 0300-5526 .- 1423-0100. ; 43:4-6, s. 288-293
  • Tidskriftsartikel (refereegranskat)abstract
    • The present study was undertaken to examine the immunogenicity of a single plasmid DNA representing the reverse transcriptase (RT) of HIV-1. Plasmids containing the enzymatically active RT as well as a mutated nonenzymatically active RT with nucleotide (nt)-binding motifs of YMDD and YMLL, respectively, were used to immunize mice. Both constructs induced similar good antibody and T cell responses, with a tendency towards antibody directed to peptides representing the active and mutated sites. Immunized mice were challenged with a murine pseudotype HIV-1/MuLV infected spleen cells. Seven out of 10 mice immunized with RT had no recoverable HIV-1, while 10 individuals immunized with the RT mutant and all the 18 controls had high levels of recoverable HIV-1. This indicates that mutation of RT reduces the desired immunogenicity.
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