SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Winblad B) srt2:(2010-2014)"

Sökning: WFRF:(Winblad B) > (2010-2014)

  • Resultat 1-10 av 115
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Besga, A., et al. (författare)
  • Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
  • 2012
  • Ingår i: Neuroscience Letters. - : Elsevier BV. - 0304-3940 .- 1872-7972. ; 510:2, s. 121-126
  • Tidskriftsartikel (refereegranskat)abstract
    • Investigate possible associations of white matter hyperintensities (WMHs) with the metabolism of cholesterol and insulin in two subgroups of patients with memory complaints and different CSF A beta 42 and CSF tau levels. 59 patients from the memory clinic at Karolinska Hospital were included. Degree of WMHs was rated using the ARWMC scale and the following biomarkers were measured in CSF and plasma: insulin, cholesterol, lanosterol, lathosterol, and oxidized cholesterol metabolites. The WMHs in CSF control-like group correlated with increased brain cholesterol synthesis and reduced efflux of oxysterols and insulin in CSF. In the CSF AD-like group, the WMHs correlated with increased peripheral cholesterol metabolism. Despite having similar appearance on FLAIR images, the pathogenic mechanisms of WMHS are likely to be different in the two groups investigated.
  •  
3.
  • Caracciolo, B, et al. (författare)
  • The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia : a cohort study of a community dwelling elderly population
  • 2011
  • Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 82:7, s. 788-793
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective To investigate the symptom of low mood as a predictor of mild cognitive impairment (MCI) and its progression to dementia, taking into account: (i) MCI severity, (ii) time of assessment and (iii) interaction with other factors.Methods 764 cognitively healthy elderly subjects living in the community, from the Kungsholmen Project. Participants were assessed by direct interview to detect low mood. Subjects were then followed for 6 years to identify those who developed MCI. People with incident MCI were followed for a further 3 years to assess progression to dementia.Results People with low mood at baseline had a 2.7-fold (95% CI 1.9 to 3.7) increased risk of developing MCI at follow-up. The association was stronger for amnestic MCI (aMCI: HR 5.8; 95% CI 3.1 to 10.9) compared with global cognitive impairment (other cognitive impairment no dementia, oCIND: HR 2.2; 95% CI 1.5 to 3.3). ApoE-ε4 interacted with low mood in a synergistic fashion, increasing the risk of aMCI, while no interaction with psychiatric, vascular, frailty related or psychosocial factors was observed. Low mood at baseline, as opposed to low mood co-occurring with MCI, was associated with a 5.3-fold (95% CI 1.2 to 23.3) increased risk of progression to dementia in aMCI. In contrast, no association was found in oCIND.Conclusion Low mood was more strongly associated with aMCI than with global cognitive impairment. Progression towards dementia was predicted only by low mood manifest in the prodromal stage of MCI. These findings indicate that low mood is particularly prominent in the very early stages of cognitive decline.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 115
Typ av publikation
tidskriftsartikel (96)
konferensbidrag (16)
bok (1)
forskningsöversikt (1)
recension (1)
Typ av innehåll
refereegranskat (89)
övrigt vetenskapligt/konstnärligt (26)
Författare/redaktör
Winblad, B (109)
Kivipelto, M (13)
Tjernberg, LO (12)
Cedazo-Minguez, A (10)
Wimo, A (10)
Jonsson, L. (9)
visa fler...
Solomon, A (9)
Gauthier, S (8)
Robert, P (8)
Ihl, R (8)
Aarsland, D (7)
Ferris, S (7)
BOGDANOVIC, N (6)
Fratiglioni, L (6)
Andreasen, N (6)
Ankarcrona, M (6)
Aoki, M. (5)
Johansson, G. (5)
Gustavsson, A. (5)
Jelic, V (5)
Frolich, L (5)
Mangialasche, F (5)
Karlstrom, H (5)
Mateos, L (5)
Soininen, H (4)
Mecocci, P (4)
Vellas, B (4)
Frisoni, GB (4)
Graff, C (4)
Pei, JJ (4)
Eriksdotter, M (4)
Bereczki, E (4)
Blennow, Kaj, 1958 (3)
Wang, S (3)
Cavallin, L (3)
Wahlund, LO (3)
Bjorkhem, I (3)
Kåreholt, Ingemar (3)
Tsolaki, M (3)
Codita, A (3)
Nishimura, T. (3)
Guan, ZZ (3)
Winblad, Ulrika (3)
Schedin-Weiss, S (3)
Pavlov, PF (3)
Leoni, V (3)
Naslund, J (3)
Sandebring, A (3)
Enache, D. (3)
Hur, JY (3)
visa färre...
Lärosäte
Karolinska Institutet (110)
Stockholms universitet (8)
Göteborgs universitet (5)
Uppsala universitet (4)
Lunds universitet (3)
Linköpings universitet (2)
visa fler...
Jönköping University (2)
Chalmers tekniska högskola (1)
Linnéuniversitetet (1)
RISE (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (115)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (22)
Samhällsvetenskap (3)
Naturvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy