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- Maguire, Sarah, et al.
(författare)
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Common Susceptibility Loci for Male Breast Cancer
- 2021
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Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 113:4, s. 453-461
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study of MBC identified 2 predisposition loci for the disease, both of which were also associated with risk of FBC.MethodsWe performed genome-wide single nucleotide polymorphism genotyping of European ancestry MBC case subjects and controls in 3 stages. Associations between directly genotyped and imputed single nucleotide polymorphisms with MBC were assessed using fixed-effects meta-analysis of 1380 cases and 3620 controls. Replication genotyping of 810 cases and 1026 controls was used to validate variants with P values less than 1 × 10–06. Genetic correlation with FBC was evaluated using linkage disequilibrium score regression, by comprehensively examining the associations of published FBC risk loci with risk of MBC and by assessing associations between a FBC polygenic risk score and MBC. All statistical tests were 2-sided.ResultsThe genome-wide association study identified 3 novel MBC susceptibility loci that attained genome-wide statistical significance (P < 5 × 10–08). Genetic correlation analysis revealed a strong shared genetic basis with estrogen receptor–positive FBC. Men in the top quintile of genetic risk had a fourfold increased risk of breast cancer relative to those in the bottom quintile (odds ratio = 3.86, 95% confidence interval = 3.07 to 4.87, P = 2.08 × 10–30).ConclusionsThese findings advance our understanding of the genetic basis of MBC, providing support for an overlapping genetic etiology with FBC and identifying a fourfold high-risk group of susceptible men.
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- Bytyci, Ibadete, et al.
(författare)
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Improved Left Atrial Function in CRT Responders : A Systematic Review and Meta-Analysis
- 2020
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 9:2
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Forskningsöversikt (refereegranskat)abstract
- Cardiac resynchronization therapy (CRT) is associated with reverse left atrial (LA) remodeling. The aim of this meta-analysis was to assess the relationship between clinical response to CRT and LA function changes. We conducted a systematic search of all electronic databases up to September 2019 which identified 488 patients from seven studies. At (mean) 6 months follow-up, LA systolic strain and emptying fraction (EF) were increased in CRT responders, with a -5.70% weighted mean difference (WMD) [95% confidence interval (CI) -8.37 to -3.04, p < 0.001 and a WMD of -8.98% [CI -15.1 to -2.84, p = 0.004], compared to non-responders. The increase in LA strain was associated with a fall in left ventricle (LV) end-systolic volume (LVESV) r = -0.56 (CI -0.68 to -0.40, p < 0.001) and an increase in the LV ejection fraction (LVEF) r = 0.58 (CI 0.42 to 0.69, p < 0.001). The increase in LA EF correlated with the fall in LVESV r = -0.51 (CI -0.63 to -0.36, p < 0.001) and the increase in the LVEF r = 0.48 (CI 0.33 to 0.61, p = 0.002). The increase in LA strain correlated with the increase in the LA EF, r = 0.57 (CI 0.43 to 0.70, p < 0.001). Thus, the improvement of LA function in CRT responders reflects LA reverse remodeling and is related to its ventricular counterpart.
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| 7. |
- Van, Dung Pham, et al.
(författare)
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Adaptive Open-Shop Scheduling for Optical Interconnection Networks
- 2017
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Ingår i: Journal of Lightwave Technology. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 0733-8724 .- 1558-2213. ; 35:13, s. 2503-2513
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Tidskriftsartikel (refereegranskat)abstract
- This paper deals with resource management in optical interconnection networks. It first proposes an optical resource management framework as a platform to develop and evaluate efficient solutions for multipoint-to-multipoint optical communication systems with a centralized controller. The paper then focuses on studying the optical resource scheduling (ORS) problem as a core element in the framework by applying the classical open-shop scheduling theory. The ORS problem can therefore be solved by adopting the existing preemptive and nonpreemptive open-shop scheduling algorithms. In an optical network with nonnegligible reconfiguration delay, a preemptive algorithm may incur high reconfiguration overhead resulting in worse performance compared to the nonpreemptive strategy. Motivated by this fact, this paper proposes an adaptive open-shop scheduling (AOS) algorithm that dynamically decides the optimal scheduling strategy according to traffic condition and system parameters, such as reconfiguration delay, nonpreemptive approximation ratio, and number of involved optical interfaces. The solution is assessed by means of an analytical model that allows to quantify the network performance in terms of packet delay and potential energy savings obtained by the sleep mode operation. As a possible application scenario, the inter- and intrarack optical interconnection networks in data centres are considered. Analytical results demonstrate how the proposed AOS outperforms the nonpreemptive and preemptive scheduling strategies for typical configurations used in data center networks. In addition, the reconfiguration delay and wake-up time of optical devices are identified as performance-determining factors.
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| 8. |
- Darrell, Trevor, et al.
(författare)
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Face-Responsive Interfaces : From Direct Manipulation to Perceptive Presence
- 2002
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Ingår i: Proceedings of the 4th international conference on Ubiquitous Computing. - : ACM Press. ; , s. 135-151
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Konferensbidrag (refereegranskat)abstract
- Systems for tracking faces using computer vision have recently become practical for human-computer interface applications. We are developing prototype systems for face-responsive interaction, exploring three different interface paradigms: direct manipulation, gazemediated agent dialog, and perceptually-driven remote presence. We consider the characteristics of these types of interactions, and assess the performance of our system on each application. We have found that face pose tracking is a potentially accurate means of cursor control and selection, is seen by users as a natural way to guide agent dialog interaction, and can be used to create perceptually-driven presence artefacts which convey real-time awareness of a remote space.
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- Chen, Deliang, 1961, et al.
(författare)
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European Trend Atlas of Extreme Temperature and Precipitation Records
- 2015
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- This Atlas presents records of climatic variability and change in Europe starting before 1901 and focuses especially on trends of extreme temperatures and precipitation. The authors have used software developed within EMULATE (European and North Atlantic daily to MULtidecadal climATE variability) to obtain the extremes indices and temporal trends. The trend atlas provides an easy way to identify spatial patterns for a given time period, region, season, and index. The Atlas clearly shows that climate in Europe has changed over the last 100 to 150 years, such that the occurrence and intensity of warm temperature extremes have increased. Precipitation extremes have also changed, but with a less clear pattern compared to the temperature extremes.
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