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- Pulit, S. L., et al.
(författare)
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Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
- 2018
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Ingår i: Neurology-Genetics. - : Ovid Technologies (Wolters Kluwer Health). - 2376-7839. ; 4:6
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Tidskriftsartikel (refereegranskat)abstract
- Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
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| 3. |
- Linåker, J., et al.
(författare)
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Motivating the contributions : An Open Innovation perspective on what to share as Open Source Software
- 2018
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Ingår i: Journal of Systems and Software. - : Elsevier Inc.. - 0164-1212 .- 1873-1228. ; 135, s. 17-36
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Tidskriftsartikel (refereegranskat)abstract
- Open Source Software (OSS) ecosystems have reshaped the ways how software-intensive firms develop products and deliver value to customers. However, firms still need support for strategic product planning in terms of what to develop internally and what to share as OSS. Existing models accurately capture commoditization in software business, but lack operational support to decide what contribution strategy to employ in terms of what and when to contribute. This study proposes a Contribution Acceptance Process (CAP) model from which firms can adopt contribution strategies that align with product strategies and planning. In a design science influenced case study executed at Sony Mobile, the CAP model was iteratively developed in close collaboration with the firm's practitioners. The CAP model helps classify artifacts according to business impact and control complexity so firms may estimate and plan whether an artifact should be contributed or not. Further, an information meta-model is proposed that helps operationalize the CAP model at the organization. The CAP model provides an operational OI perspective on what firms involved in OSS ecosystems should share, by helping them motivate contributions through the creation of contribution strategies. The goal is to help maximize return on investment and sustain needed influence in OSS ecosystems. © 2017
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