| 1. |
- Chen, Tianhui, et al.
(författare)
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IGF-I during primiparous pregnancy and maternal risk of breast cancer
- 2010
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Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 0167-6806 .- 1573-7217. ; 121:1, s. 169-175
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Tidskriftsartikel (refereegranskat)abstract
- Previously, we reported that insulin-like growth factor (IGF)-I during early pregnancy is positively associated with maternal risk of breast cancer. To further explore this association, we designed a new study limited to women who donated a blood sample during their first pregnancy ending with childbirth. A case-control study was nested within the Northern Sweden Maternity Cohort in which repository since 1975, serum specimens remaining after early pregnancy screening for infectious diseases had been preserved. Study subjects were selected among women who donated a blood sample during the full-term pregnancy that led to the birth of their first child. Two hundred and forty-four women with invasive breast cancer were eligible. Two controls, matching the index case for age and date at blood donation were selected (n = 453). IGF-I was measured in serum samples on an Immulite 2000 analyzer. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals. A significant positive association of breast cancer with IGF-I was observed, with OR of 1.73 (95% CI: 1.14-2.63) for the top tertile, P < 0.009. Subgroup analyses did not indicate statistical heterogeneity of the association by ages at sampling and diagnosis or by lag time to cancer diagnosis, although somewhat stronger associations with risk were observed in women < or = age 25 at index pregnancy and for cases diagnosed within 15 years of blood donation. The results of the study add further evidence for an adverse effect of elevated IGF-I concentrations during early reproductive life on risk of breast cancer.
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| 2. |
- Chen, Tianhui, et al.
(författare)
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Maternal hormones during early pregnancy : a cross-sectional study
- 2010
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Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 21:5, s. 719-727
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Little is known about correlates of first-trimester pregnancy hormones as in most studies maternal hormones have been measured later in gestation. We examined the associations of maternal characteristics and child sex with first-trimester maternal concentrations of four hormones implicated in breast cancer: human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), insulin-like growth factor (IGF)-I, and IGF-II. METHODS: About 338 serum samples donated to the Northern Sweden Maternity Cohort (NSMC), 1975-2001, during the first trimester of uncomplicated pregnancies, were analyzed for the hormones of interest as a part of a case-control study. The associations of maternal characteristics and child sex with hormone concentrations were investigated by correlation, general linear regression, and multivariate regression models. RESULTS: In the first trimester, greater maternal age was inversely correlated with IGF-I and IGF-II. In comparison with women carrying their first child, already parous women had higher IGF-I but lower hCG. Greater maternal weight and smoking were inversely correlated with hCG. No differences in hormone levels by child sex were observed. CONCLUSIONS: Our analyses indicated that potentially modifiable maternal characteristics (maternal weight and smoking) influence first-trimester pregnancy maternal hormone concentrations.
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| 4. |
- Högdin, Sara, 1972-, et al.
(författare)
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Strategier för höjd utbildningsnivå : En studie bland unga i Åstorps kommun
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Flera tidigare studier visar att utbildningstraditionen i samhället har förändrats. Idag utbildar sig fler på gymnasiet och fler läser vidare på högre utbildningar vilket innebär att utbildningsnivån i vårt samhälle ökat. Utbildningssystemet beskrivs ofta som ett “självreproducerande system”, där benägenhet att välja en viss utbildning i hög grad är beroende av utbildningstradition, framför allt i familjen, men också i samhället runt individen. I Åstorps kommun har en låg utbildningstradition uppmärksammats. Det är inte ovanligt med avhopp från gymnasiet och ett flertal gymnasieelever slutför inte sin gymnasieutbildning inom de avsedda tre åren. När det gäller högre studier vid högskola eller universitet ligger utbildningsnivån i Åstorps kommun lägre än riksgenomsnittet. Med anledning av detta beslutade Åstorps kommun att följa upp gymnasieeleverna genom en studie. Studiens syfte är att tillvara erfarenheter av utbildning bland ungdomar i Åstorps kommun samt öka kunskapen om hur ungdomarna ser på framtida utbildnings- och karriärmöjligheter. Resultaten i studien visar att många ungdomar efterfrågar mer stöd från vuxna i skolan när det kommer till val av utbildning och framtida yrke.
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| 5. |
- Högström, Karin, 1964-
(författare)
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Orientalisk dans i Stockholm : Femininiteter, möjligheter och begränsningar
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of the dissertation is to describe and analyze the practice and meaning of Middle Eastern dance through the study of a number of performers in Stockholm. In particular, this study emphasises the ways in which the performers seek, create and defend values such as femininity, authenticity, empowerment and respectability in and through their dancing.Data for this study consists of field notes from participant observation in dance classes, festivals and gatherings; in-depth interviews and written material, such as leaflets and Internet material. Field notes from a trip to Lebanon with a group of Swedish dancers are also included.The performance of Middle Eastern dance in Stockholm may be seen as a way for Swedish women to find new femininities. They strive to combine a glamorous hyper-femininity with strength and respectability. This is a difficult task. The dancers constantly have to maintain a balance. While enjoying the hyper-femininity of oriental dance they must avoid being too sexy and thereby running the risk of being reduced to the position of sexual objects. To avoid losing control of the situation performing in public the dancers use different tactics. Many try to make the performance a clearly bounded event and make distinctions between themselves as individuals and the personas they embody on stage. This gives the performers a chance to playfully embody hyper-femininity. Other dancers have changed the dance itself, removing all movements and costumes that could be perceived as sexually inviting or aiming to please.
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| 6. |
- Sarajeva, Katja, 1977-
(författare)
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Lesbian Lives : Sexuality, Space and Subculture in Moscow
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This study is an exploration of the lesbian subculture in Russia focusing in particular on the subculture as a unique heterogeneous space of social interaction and cultural production that is not self contained or isolated from mainstream society, but incorporates a variety of cultural flows and traditions that are a part of Russian mainstream culture, other Russian subcultures, or global cultural flows. Some of these cultural flows and traditions are more compatible than other ones.The increasingly globalized images and ideas of what a gay and lesbian community is, or perhaps should be like, are only partially compatible with contemporary reality in Russia. The high value placed on visibility and explicitly political, even radical activism, in gay and lesbian subcultures in the West, must in Russia be reconciled not only with the totalitarian past, and the increasingly authoritarian present, but also with the traditions and practices that developed as a response to the repressive regime and enabled people to live and even thrive within it. Using private spaces as public space, and public space as private space established a practice of multilayered spaces that are continuously maintained through social inclusion and exclusion, visibility and invisibility.However, the subculture is not only an intersection of external cultural flows and traditions, it also has it’s own unique traditions, knowledges and practices. Poetry, music, literature and art form the backbone of the flow of activities within the subculture. Visual and grammatical cues, styles, jokes and lesbian genders are integral aspects of the subculture as it is continuously renegotiated by its participants also on an individual level..The study is based on fieldwork, participant observation and interviews, mainly in Moscow, and to some extent in St Petersburg, during 2005 with recurring visits during 2006 and 2007.
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| 7. |
- Toniolo, Paolo, et al.
(författare)
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Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer
- 2010
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Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 70:17, s. 6779-6786
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Tidskriftsartikel (refereegranskat)abstract
- Full-term pregnancies are associated with long-term reductions in maternal risk of breast cancer, but the biological determinants of the protection are unknown. Experimental observations suggest that human chorionic gonadotropin (hCG), a major hormone of pregnancy, could play a role in this association. A case-control study (242 cases and 450 controls) nested within the Northern Sweden Maternity Cohort included women who had donated a blood sample during the first trimester of a first full-term pregnancy. Total hCG was determined on Immulite 2000 analyzer. Odds ratios (OR) and 95% confidence intervals (CI) were estimated through conditional logistic regression. Maternal breast cancer risk decreased with increasing hCG (upper tertile OR, 0.67; CI, 0.46-0.99), especially for pregnancies before age 25 (upper tertile OR, 0.41; CI, 0.21-0.80). The association diverged according to age at diagnosis: risk was reduced after age 40 (upper tertile OR, 0.60; CI, 0.39-0.91) and seemed to increase before age 40 (upper tertile OR, 1.78; CI, 0.72-4.38). Risk was reduced among those diagnosed 10 years or longer after blood draw (upper tertile OR, 0.60; CI, 0.40-0.90), but not so among those diagnosed within 10 years (upper tertile OR, 4.33; CI, 0.86-21.7). These observations suggest that the association between pregnancy hCG and subsequent maternal risk of breast cancer is modified by age at diagnosis. Although the hormone seems to be a determinant of the reduced risk around or after age 50, it might not confer protection against, or it could even increase the risk of, cancers diagnosed in the years immediately following pregnancy.
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