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1.	Zhao, XY, et al. (author) A large-scale genome-wide cross-trait analysis for the effect of COVID-19 on female-specific cancers 2023 In: iScience. - 2589-0042. ; 26:9, s. 107497- Journal article (peer-reviewed)
2.	Darst, BF, et al. (author) Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry 2023 In: American journal of human genetics. - : Cell Press. - 1537-6605 .- 0002-9297. ; 110:7, s. 1200- Journal article (peer-reviewed)
3.	Wu, XY, et al. (author) Investigating the relationship between depression and breast cancer: observational and genetic analyses 2023 In: BMC medicine. - 1741-7015. ; 21:1, s. 170- Journal article (peer-reviewed)
4.	Zhang, L, et al. (author) Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses 2023 In: BMC medicine. - 1741-7015. ; 21:1, s. 353- Journal article (peer-reviewed)
5.	Cui, HJ, et al. (author) Epidemiological and genetic evidence for the relationship between ABO blood group and human cancer 2023 In: International journal of cancer. - 1097-0215. ; 153:2, s. 320-330 Journal article (peer-reviewed)
6.	Darst, BF, et al. (author) Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry 2023 In: medRxiv : the preprint server for health sciences. Journal article (other academic/artistic)
7.	Qu, Y, et al. (author) Genetic Correlation, Shared Loci, and Causal Association Between Sex Hormone-Binding Globulin and Bone Mineral Density: Insights From a Large-Scale Genomewide Cross-Trait Analysis 2023 In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 1523-4681. ; 38:11, s. 1635-1644 Journal article (peer-reviewed)
8.	Wang, YT, et al. (author) Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses 2023 In: Journal of translational medicine. - 1479-5876. ; 21:1, s. 671- Journal article (peer-reviewed)
9.	Zhang, L, et al. (author) Using human genetics to understand the epidemiological association between obesity, serum urate, and gout 2023 In: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 62:10, s. 3280-3290 Journal article (peer-reviewed)abstract ObjectivesWe aimed to clarify the genetic overlaps underlying obesity-related traits, serum urate, and gout.MethodsWe conducted a comprehensive genome-wide cross-trait analysis to identify genetic correlation, pleiotropic loci, and causal relationships between obesity (the exposure variable), gout (the primary outcome) and serum urate (the secondary outcome). Summary statistics were collected from the hitherto largest genome-wide association studies conducted for BMI (N = 806 834), waist-to-hip ratio (WHR; N = 697 734), WHR adjusted for BMI (WHRadjBMI; N = 694 649), serum urate (N = 288 649), and gout (Ncases = 13 179 and Ncontrols = 750 634).ResultsPositive overall genetic correlations were observed for BMI (rg = 0.27, P = 6.62 × 10−7), WHR (rg = 0.22, P = 6.26 × 10−7) and WHRadjBMI (rg = 0.07, P = 6.08 × 10−3) with gout. Partitioning the whole genome into 1703 LD (linkage disequilibrium)-independent regions, a significant local signal at 4q22 was identified for BMI and gout. The global and local shared genetic basis was further strengthened by the multiple pleiotropic loci identified in the cross-phenotype association study, multiple shared gene–tissue pairs observed by Transcriptome-wide association studies, as well as causal relationships demonstrated by Mendelian randomization [BMI–gout: OR (odds ratio) = 1.66, 95% CI = 1.45, 1.88; WHR–gout: OR = 1.57, 95% CI = 1.37, 1.81]. Replacing the binary disease status of gout with its latent pathological measure, serum urate, a similar pattern of correlation, pleiotropy and causality was observed with even more pronounced magnitude and significance.ConclusionOur comprehensive genome-wide cross-trait analysis demonstrates a shared genetic basis and pleiotropic loci, as well as a causal relationship between obesity, serum urate, and gout, highlighting an intrinsic link underlying these complex traits.
10.	Zhang, WQ, et al. (author) Additional Evidence for the Relationship Between Type 2 Diabetes and Stroke Through Observational and Genetic Analyses 2023 In: Diabetes. - 1939-327X. ; 72:11, s. 1671-1681 Journal article (peer-reviewed)

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Result 1-10 of 11

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Type of publication: journal article (11)

Type of content: peer-reviewed (10); other academic/artistic (1)

Author/Editor: Zhang, L. (9); Zhang, B. (9); Jiang, X. (9); Chen, L (6); Yang, C. (6); Wang, YT (6); show more...; Liu, YJ (6); Zhao, XY (4); Wang, Y. (2); Brenner, H (2); Qu, Y (2); SCHAID, DJ (2); Teo, SH (2); Muir, K (2); Nordestgaard, BG (2); Haiman, CA (2); Le Marchand, L (2); Chanock, SJ (2); Easton, DF (2); Kogevinas, M (2); Mucci, LA (2); He, L (2); Kibel, AS (2); Hunter, DJ (2); John, EM (2); Casey, G (2); Kote-Jarai, Z (2); Berndt, SI (2); Conti, DV (2); Dadaev, T (2); Wan, P (2); Sheng, X (2); Schleutker, J (2); Travis, RC (2); Khaw, KT (2); Pashayan, N (2); Nielsen, SF (2); Thibodeau, SN (2); Stanford, JL (2); Maier, C (2); Yeboah, ED (2); Cannon-Albright, L (2); Cybulski, C (2); Isaacs, WB (2); Penney, KL (2); Ingles, SA (2); Kittles, RA (2); Murphy, AB (2); Pandha, H (2); Albanes, D (2); show less...

University: Karolinska Institutet (11); Uppsala University (1)

Language: English (11)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2023 (11)Undo refine

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