| 1. |
- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
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| 3. |
- Armandi, Angelo, et al.
(författare)
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Serum ferritin levels can predict long-term outcomes in patients with metabolic dysfunction-associated steatotic liver disease
- 2024
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Ingår i: Gut. - : BMJ PUBLISHING GROUP. - 0017-5749 .- 1468-3288.
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Tidskriftsartikel (refereegranskat)abstract
- Objective Hyperferritinaemia is associated with liver fibrosis severity in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but the longitudinal implications have not been thoroughly investigated. We assessed the role of serum ferritin in predicting long-term outcomes or death. Design We evaluated the relationship between baseline serum ferritin and longitudinal events in a multicentre cohort of 1342 patients. Four survival models considering ferritin with confounders or non-invasive scoring systems were applied with repeated five-fold cross-validation schema. Prediction performance was evaluated in terms of Harrell's C-index and its improvement by including ferritin as a covariate. Results Median follow-up time was 96 months. Liver-related events occurred in 7.7%, hepatocellular carcinoma in 1.9%, cardiovascular events in 10.9%, extrahepatic cancers in 8.3% and all-cause mortality in 5.8%. Hyperferritinaemia was associated with a 50% increased risk of liver-related events and 27% of all-cause mortality. A stepwise increase in baseline ferritin thresholds was associated with a statistical increase in C-index, ranging between 0.02 (lasso-penalised Cox regression) and 0.03 (ridge-penalised Cox regression); the risk of developing liver-related events mainly increased from threshold 215.5 mu g/L (median HR=1.71 and C-index=0.71) and the risk of overall mortality from threshold 272 mu g/L (median HR=1.49 and C-index=0.70). The inclusion of serum ferritin thresholds (215.5 mu g/L and 272 mu g/L) in predictive models increased the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score in the longitudinal risk assessment of liver-related events (C-indices>0.71) and overall mortality (C-indices>0.65). Conclusions This study supports the potential use of serum ferritin values for predicting the long-term prognosis of patients with MASLD.
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| 4. |
- Elkadeem, M. R., et al.
(författare)
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Geospatial-assisted multi-criterion analysis of solar and wind power geographical-technical-economic potential assessment
- 2022
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Ingår i: Applied Energy. - : Elsevier Ltd. - 0306-2619 .- 1872-9118. ; 322
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Tidskriftsartikel (refereegranskat)abstract
- Amid the increasing electricity demand, energy crisis and pollution, the transition to renewable energy (RE) is becoming a preoccupation and major global challenge due to the multidimensional and intricate problem of RE planning. In Egypt, about 90% of gross power generation comes from carbon-intensive power plants (natural gas and coal). Here, we propose a novel geospatial-decision-making model aimed at geographical-technical–economic potential mapping and assessment of solar photovoltaic (PV) and onshore wind turbine (WT) power plants at a high level of resolution (1 km2) in Egypt. We identify the locations suitable for PV and WT development considering sixteen restrictive and contradictory evaluation criteria. These locations have been further analyzed to estimate how much energy generation is available and at what energy cost. The analysis identifies Middle-Upper Egypt and Suez Canal as hosting the majority of highly suitable locations for PV and WT power plants, respectively. Our finding reveals that the proper planning on RE projects at the proposed optimum locations could support the country's energy mix with a sizable 32% share of the projected country's electricity consumption from PV and 50% share from WT, by 2030. Furthermore, we show that the investment opportunities of PV and WT generation are potentially attractive with affordable competitive prices estimated at 57.84 $/MWh and 32.36 $/MWh, respectively, against conventional generation for today and the future. We anticipate that our results will provide valuable support in realizing Egypt's vision for sustainable electricity generation and in keeping abreast of the global transformation in power systems being witnessed. Ultimately, the method's relevance extends beyond the geographical boundaries of the present territory; it features a strategic, clear and reproducible approach that may be applied to a larger area or continent, provided the necessary input data and criteria are introduced.
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| 5. |
- Elkadeem, M. R., et al.
(författare)
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Sustainable siting and design optimization of hybrid renewable energy system : A geospatial multi-criteria analysis
- 2021
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Ingår i: Applied Energy. - : Elsevier Ltd. - 0306-2619 .- 1872-9118. ; 295
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Tidskriftsartikel (refereegranskat)abstract
- The use of hybrid renewable energy system (HRES) holds great promise for sustainable electrification and support countries reaching their energy access goals. The site selection and design of HRES are strategic stages towards ensuring an affordable, sustainable, and well-performing project. However, both are multidimensional and intricate issues that involve multiple conflicting assessment criteria and alternatives, which are not yet investigated comprehensively and simultaneously in many of the existing literature. In this context, the paper aims to develop a systematic and conceptual decision-making framework for site suitability and optimal design of HRESs, with an application on a regional scale in Kenya, Sub-Saharan Africa. The suggested framework is applied through three consecutive phases. First, a geographical information system (GIS) is combined with Best Worst Method (BWM) decision-making approach to spatially investigate and analyze the potential sites of solar, wind, and hybrid solar/wind systems. Within the spatial investigation, 9 different climatology, environment, location, and orography criteria are considered. Second, energy-economy-ecology (E3) design optimization is conducted to determine the list of feasible alternatives among grid-extension, autonomous HRES, and stand-alone diesel genset electrification schemes for powering a representative remote rural village in Kenya. Third, a post-optimality multi-criteria decision-making (MCDM) analysis is applied to decide and assess the optimal energy access design against 12 key sustainability indicators. In the third phase, the BWM is employed to define the weights of each indicator. Then, the Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) and the VIšekriterijumsko KOmpromisno Rangiranje (VIKOR) decision making approaches are used for the final ranking of feasible alternatives. The obtained site suitability maps of Kenya show that 0.91% (5322 km2) and 1.5% (8828.4 km2) of the land is highly suitable, 10.25% (59687 km2) and 33.04% (192360 km2) is suitable, and 80.5% (470313 km2) and 65% (378407 km2) is permanently unsuitable for establishing solar and wind systems, respectively. Also, E3-MCDM results indicate that the development of solar/wind/diesel/battery HRES is the best sustainable solution to supply the studied region as compared to other feasible alternatives. The system does not only guarantee a reliable operation with an unmet load of 552 kWh/yr, but it also has the lowest net present and energy costs at 2.6 M$ and 0.28 $/kWh, respectively, meanwhile avoiding annual CO2 of 804 tons compared with diesel system.
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| 6. |
- Younes, George, et al.
(författare)
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X-Ray Burst and Persistent Emission Properties of the Magnetar SGR 1830-0645 in Outburst
- 2022
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 1538-4357 .- 0004-637X. ; 924:2
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Tidskriftsartikel (refereegranskat)abstract
- We report on NICER X-ray monitoring of the magnetar SGR 1830-0645 covering 223 days following its 2020 October outburst, as well as Chandra and radio observations. We present the most accurate spin ephemerides of the source so far: nu = 0.096008680(2) Hz, = -6.2(1) x 10(-14) Hz s(-1), and significant second and third frequency derivative terms indicative of nonnegligible timing noise. The phase-averaged 0.8-7 keV spectrum is well fit with a double-blackbody (BB) model throughout the campaign. The BB temperatures remain constant at 0.46 and 1.2 keV. The areas and flux of each component decreased by a factor of 6, initially through a steep decay trend lasting about 46 days, followed by a shallow long-term one. The pulse shape in the same energy range is initially complex, exhibiting three distinct peaks, yet with clear continuous evolution throughout the outburst toward a simpler, single-pulse shape. The rms pulsed fraction is high and increases from about 40% to 50%. We find no dependence of pulse shape or fraction on energy. These results suggest that multiple hot spots, possibly possessing temperature gradients, emerged at outburst onset and shrank as the outburst decayed. We detect 84 faint bursts with NICER, having a strong preference for occurring close to the surface emission pulse maximum-the first time this phenomenon is detected in such a large burst sample. This likely implies a very low altitude for the burst emission region and a triggering mechanism connected to the surface active zone. Finally, our radio observations at several epochs and multiple frequencies reveal no evidence of pulsed or burst-like radio emission.
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