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- Ding, Zong-Hai, et al.
(författare)
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Evaluation of strain hardening parameters
- 2004
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Ingår i: Journal of Iron and Steel Research International. - 1006-706X .- 2210-3988. ; 11:4, s. 38-46
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Tidskriftsartikel (refereegranskat)abstract
- The plane-strain compression test for three kinds of materials was carried out in a temperature range between room temperature and 400 degreesC. The sigma-epsilon curves and strain-hardening rate at different temperatures were simulated and a reasonable fit to the experimental data was obtained. A modified model created by data inference and computer simulation was developed to describe the strain hardening at a large deformation, and the predicted strain hardening are in a good agreement with that observed in a large range of stress. The influences of different parameters on strain hardening behaviour under large deformation were analysed. The temperature increase within the test temperatures for stainless steel 18/8 Ti results in dropping of flow stress and strain-hardening rate. For favourable gamma-fibre texture to obtain high r, the cold rolling was applied at large reduction. In the experimental procedure, the X-ray diffraction test was carried out to compare the strain hardening and microstructure under large deformation for a bcc steel (low carbon steel SS-1142). The results indicate that the high strain-hardening rate possibly occurs when the primary slip plane 110 is parallel to the rolling plane and the strain-hardening rate decreases when lots of 110 plane rotate out from the orientation {110}//RP.
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| 3. |
- Yang, Hai-Tao
(författare)
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Genetic analysis of autoimmune diseases using animal models : Mapping susceptibility genes for multiple sclerosis and rheumatoid arthritis
- 2000
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are common human diseasesaffecting 1% and 0.1% of the population respectively. These diseases are characterized by abnormal self-tolerance in the immune system and autoimmune reactions. Epidemiological studies indicate that geneticcomponents together with environmental factors influence these diseases.The etiology of autoimmune diseases is poorly understood. Previous studies have found that MHCgenes are important for disease but these studies also indicated that additional genes are involved.Studies of complex diseases such as autoimmune diseases are difficult because they are caused by more than one gene or the interactions between several genes along with environmental factors. Directanalysis of complex diseases in human families is often hampered by incomplete penetrance, phenocopies and genetic heterogeneity.Analysing complex diseases by using animal models provides a shortcut because environmental factors can be controlled and the populations are more homogenous. This thesis work has analysed several animal models for autoimmune diseases in mice and rats by genome-wide scans and multi-trait quantitative trait loci (QTL) linkage analysis. Experimental allergic encephalomyelitis (EAE) is an animal model for human MS and collagen induced arthritis (CIA) is a model for RA.We found a number of susceptiblility loci for EAE and CIA which mapped to different chromosomal regions. We mapped 3 non-MHC loci in the EAE mouse model. Also. 4 loci were mapped in the mouse CIA model and 11 loci in the EAE rat model. Among these susceptibile loci, we found that some of them are shared between EAE and arthritis and therefore may contain common autoimmune disease genes.
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