| 1. |
- Wang, Fang, et al.
(författare)
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Emerging contaminants: A One Health perspective
- 2024
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Ingår i: Innovation. - 2666-6758. ; 5
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Forskningsöversikt (refereegranskat)abstract
- Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both people and the planet. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the ongoing efforts to establish the UN's Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.
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| 2. |
- Yang, Anning, et al.
(författare)
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Homocysteine accelerates hepatocyte autophagy by upregulating TFEB via DNMT3b-mediated DNA hypomethylation
- 2023
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Ingår i: Acta Biochimica et Biophysica Sinica. - : China Science Publishing & Media Ltd.. - 1672-9145. ; 55:8, s. 1184-1192
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Tidskriftsartikel (refereegranskat)abstract
- Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. High level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying mechanism is still unknown. Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB (TFEB). The results show that Hcy-induced autophagy level is mediated by upregulation of TFEB. Silencing of TFEB decreases the level of autophagy-related protein LC3BII/I and increases p62 expression level in hepatocytes after exposure to Hcy. Moreover, the effect of Hcy on the expression of TFEB is regulated by hypomethylation of the TFEB promoter catalyzed by DNA methyltransferase 3b (DNMT3b). In summary, this study shows that Hcy can activate autophagy by inhibiting DNMT3b-mediated DNA methylation and upregulating TFEB expression. These findings provide another new mechanism for Hcy-induced autophagy in hepatocytes.
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| 3. |
- Bai, Ru, et al.
(författare)
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The NF-κB modulated miR-194-5p/IGF1R/PPFIBP axis is crucial for the tumorigenesis of ovarian cancer
- 2020
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Ingår i: Journal of Cancer. - : Ivyspring International Publisher. - 1837-9664. ; 11:12, s. 3433-3445
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Tidskriftsartikel (refereegranskat)abstract
- miRNAs are involved in the tumorigenesis of various malignancies. In the current study, we found that miR-194-5p expression is downregulated in ovarian cancer tissues, and downregulation of miR-194-5p expression promotes proliferation, invasion and migration of human ovarian cancer cells in vitro and ovarian tumor growth in nude mice. We further found that IGF1R and PPFIBP are targets of miR-194-5p, and downregulation of miR-194-5p expression increases IGF1R and PPFIBP expression, resulting in increased proliferation, invasion and migration of ovarian cancer cells. Moreover, we showed that NF-κB can bind to the promoter region of miR-194-5p, and negatively regulate the expression of miR-194-5p in ovarian cancer cells. Taken together, our results suggested a NF-κB modulated miR-194-5p/IGF1R/ PPFIBP axis that is crucial for the tumorigenesis of ovarian cancer, which provides a new insight into the development of ovarian cancer.
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| 4. |
- Chen, Hongxia, et al.
(författare)
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PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation
- 2024
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Ingår i: Molecular Cancer Research. - 1541-7786. ; 22:1, s. 94-103
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Tidskriftsartikel (refereegranskat)abstract
- Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT signaling in leukemia cells, promoting their proliferation and survival. We found that PRL2 dephosphorylates CBL at tyrosine 371 and inhibits its activity toward KIT, leading to decreased KIT ubiquitination and enhanced AKT and ERK signaling in leukemia cells.
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| 5. |
- Ke, Hengning, et al.
(författare)
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High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
- 2020
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Ingår i: Journal of Cancer. - : Ivyspring International Publisher. - 1837-9664. ; 11:23, s. 6760-6767
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Tidskriftsartikel (refereegranskat)abstract
- Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34highα6-integrinhigh compared to CD34lowα6-integrinhigh cells isolated from ultraviolet-induced squamous cell carcinoma could propagate effectively by displaying greater tumour initiating and self-renewal abilities. Our study suggests that CD34highα6-integrinhigh cells act as initiators upon ultraviolet-induced skin squamous cell carcinoma.
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| 6. |
- Liu, Yujia, et al.
(författare)
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Human-Computer Collaborative Interaction Design of Intelligent Vehicle—A Case Study of HMI of Adaptive Cruise Control
- 2021
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Ingår i: HCI in Mobility, Transport, and Automotive Systems. - Cham : Springer. - 9783030783570 - 9783030783587 ; , s. 296-314
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Konferensbidrag (refereegranskat)abstract
- With the rapid development of the intelligent vehicle industry, in order to improve the efficiency and usability of systems, the interface design of the Human-Computer Interaction of intelligent vehicles has received great attention. In this article, firstly, combined with the domestic and foreign taxonomy of automated driving systems and collaborative design concepts, a framework of human-computer collaborative interaction (Human-Engaged Automated Driving, HEAD) is proposed. Secondly, we discussed the engagement of people and intelligent vehicle at different levels. We analyzed the interaction flow chart under the Human-Computer Collaboration, established the information architecture of Human-Computer Engagement, and conducted the design practice on the Human-Machine Interface. Finally, a case study of the HMI design of Adaptive Cruise Control was performed to validate the HEAD framework. SUS usability test was performed together with an experiment evaluating interface elements in two interface designs: Original UI design and Iterative UI design. This also including a Likert scale questionnaire. The results show that HEAD can guide and improve the Human-Machine Interface design to enhance the efficiency of Human-Computer Interaction and user experience.
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| 7. |
- Wang, Jianmin, et al.
(författare)
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Experimental Study on Abstract Expression of Human-Robot Emotional Communication
- 2021
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Ingår i: Symmetry. - : MDPI AG. - 2073-8994. ; 13:9
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Tidskriftsartikel (refereegranskat)abstract
- With the continuous development of intelligent product interaction technology, the facial expression design of virtual images on the interactive interface of intelligent products has become an important research topic. Based on the current research on facial expression design of existing intelligent products, we symmetrically mapped the PAD (pleasure-arousal-dominance) emotion value to the image design, explored the characteristics of abstract expressions and the principles of expression design, and evaluated them experimentally. In this study, the experiment of PAD scores was conducted on the emotion expression design of abstract expressions, and the data results were analyzed to iterate the expression design. The experimental results show that PAD values can effectively guide designers in expression design. Meanwhile, the efficiency and recognition accuracy of human communication with abstract expression design can be improved by facial auxiliary elements and eyebrows.
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| 8. |
- Wang, Jianmin, et al.
(författare)
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The Situation Awareness and Usability Research of Different HUD HMI Design in Driving While Using Adaptive Cruise Control
- 2020
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Ingår i: HCI International 2020 – Late Breaking Papers: Digital Human Modeling and Ergonomics, Mobility and Intelligent Environments. - Cham : Springer. - 9783030599867 - 9783030599874 ; , s. 236-248
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Konferensbidrag (refereegranskat)abstract
- Head-Up display (HUD) is increasingly applied to automobiles. However, HUD might have also shortcomings causing new driving problems. This paper investigates the effects of different Human Machine Interfaces (HMI) of HUD under ACC function on situation awareness (SA) and system usability for cut-in driving scenarios. The laboratory-based controlled experiment conducted used a driving simulator with a total of 8 participants. Each participant performed three different tasks, using three different HMIs including two HUD HMI and one baseline HMI (dashboard HMI). The results indicate that HUD display can influence the participants’ SA and system usability, and that different HUD design can have different effects. The HUD design with dynamic directivity of augmented reality brings about better SA and system usability. The research suggest that it is possible to improve the SA and system usability through improved HUD-HMI design.
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| 9. |
- You, Fang, et al.
(författare)
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Icon Design Recommendations for Central Consoles of Intelligent Vehicles
- 2020
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Ingår i: Human Interaction, Emerging Technologies and Future Applications II. - Cham : Springer. - 9783030442668 - 9783030442675 ; , s. 285-291
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Konferensbidrag (refereegranskat)abstract
- Advances in vehicle technology open up both opportunities and challenges for human-machine interface (HMI) design in intelligent vehicles. Design guidelines for icons in central consoles of vehicles have been discussed in human-computer interaction community, but more study and innovation are needed in icon design. In this paper, we investigated the displayed line thickness and size of icons in the intelligent vehicle’s central control screen, based on international design guidelines and standards. The experiment involved 17 participants performing simulated in-vehicle secondary task. The result from the experiments shows that the usability of icons increases and the driver’s workload decreases as the icons get larger. We also found a set of recommended values for size and line thickness of icons in this context. Future work will focus on providing design guidelines for other aspects of HMI design in intelligent vehicles.
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| 10. |
- You, Fang, et al.
(författare)
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Interface Color Design of Intelligent Vehicle Central Console
- 2021
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Ingår i: Advances in Usability, User Experience, Wearable and Assistive Technology. - Cham : Springer Nature. - 9783030800901 - 9783030800918 ; , s. 784-792
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Konferensbidrag (refereegranskat)abstract
- The development of intelligent automobiles puts forward higher requirements for HMI design. The information obtained by drivers through vision accounts for 80%. As a key part of visual perception, color affects driving performance. This article investigates vehicle interface design about icon-background contrast. Three colors commonly used in car-machine interface are chosen: red, green and blue, and contrast is divided into five levels under daytime and nighttime. The participants tested three colors and the five contrasts in an experiment using classic paradigm of secondary tasks. We collected data from their driving behavior and subjective experience, trying to find a most appropriate value. The results show that recommended contrast values under different lighting conditions are 3:1 to 4:1 for red, blue, and green during the day; 3:1 for red at night, and 5:1 for blue and green, so that the vehicle central console color design references are formed.
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