| 1. |
- Zhang, Yinping, et al.
(författare)
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Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China
- 2013
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Ingår i: Chinese Science Bulletin. - : Springer Science and Business Media LLC. - 1001-6538 .- 1861-9541. ; 58:34, s. 4182-4189
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Tidskriftsartikel (refereegranskat)abstract
- Asthma, rhinitis and eczema (allergic or non-allergic) have increased throughout the world during the last decades, especially among children. Changes in the indoor environment are suspected to be important causes. China has experienced a dramatic change in indoor environmental exposures during the past two decades. However, such changes and their associations with children's asthma and other health aspects have not been thoroughly studied. China, Children, Homes, Health (CCHH), Phase I, was a cross-sectional questionnaire survey of 48219 children 1-8 years old in 10 Chinese cities during 2010-2012. The questionnaire includes the International Study of Asthma and Allergies in Childhood (ISAAC) core health questions and additional questions regarding housing, life habits and outdoor environment. In health analyses, children aged 3-6 years old were included. The prevalences of doctor diagnosed asthma varied from 1.7% to 9.8% (mean 6.8%), a large increase from 0.91% in 1999 and 1.50% in 2000. The prevalence of wheeze, rhinitis and atopic eczema (last 12 months) varied from 13.9% to 23.7%, 24.0% to 50.8% and 4.8% to 15.8%, respectively. Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest, except for wheezewhere the highest value was for Urumqi. We found (1) no obvious association between disease prevalences and ambient PM10 concentrations and (2) higher prevalences of disease in humid climates with hot summers and cold winters, but with no centrally heated buildings. Associations between the diseases and economic status as indexed by Gross Domestic Product (GDP) requires further study.
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| 2. |
- Hou, Xu, et al.
(författare)
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PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets
- 2010
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 107:27, s. 12216-12221
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Tidskriftsartikel (refereegranskat)abstract
- The importance of identifying VEGF-independent pathways in pathological angiogenesis is increasingly recognized as a result of the emerging drug resistance to anti-VEGF therapies. PDGF-CC is the third member of the PDGF family discovered after more than two decades of studies on PDGF-AA and PDGF-BB. The biological function of PDGF-CC and the underlying cellular and molecular mechanisms remain largely unexplored. Here, using different animal models, we report that PDGF-CC inhibition by neutralizing antibody, shRNA, or genetic deletion suppressed both choroidal and retinal neovascularization. Importantly, we revealed that PDGF-CC targeting acted not only on multiple cell types important for pathological angiogenesis, such as vascular mural and endothelial cells, macrophages, choroidal fibroblasts and retinal pigment epithelial cells, but also on the expression of other important angiogenic genes, such as PDGF-BB and PDGF receptors. At a molecular level, we found that PDGF-CC regulated glycogen synthase kinase (GSK)-3beta phosphorylation and expression both in vitro and in vivo. Activation of GSK3beta impaired PDGF-CC-induced angiogenesis, and inhibition of GSK3beta abolished the antiangiogenic effect of PDGF-CC blockade. Thus, we identified PDGF-CC as an important candidate target gene for antiangiogenic therapy, and PDGF-CC inhibition may be of therapeutic value in treating neovascular diseases.
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| 3. |
- Li, Dewei, et al.
(författare)
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Effects of Electromagnetic Swirling Flow in Submerged Entry Nozzle on Square Billet Continuous Casting of Steel Process
- 2013
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Ingår i: ISIJ International. - : Iron and Steel Institute of Japan. - 0915-1559 .- 1347-5460. ; 53:7, s. 1187-1194
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Tidskriftsartikel (refereegranskat)abstract
- In this study, a new method for swirling flow generation in submerged entry nozzle (SEN) in continuous casting of steel process has been proposed. A rotating electromagnetic field is set up around the SEN to induce swirling flow in it by the Lorentz force. And this kind of electromagnetic swirling flow in the SEN is proposed to use in square billet continuous casting of steel process. The effects of coil current intensity and nozzle structure on the flow and temperature fields in the SEN and mold are numerically simulated and verified by an electromagnetic swirling model experiment of low melting point alloy. The overall results of the study show that the magnetic flux density and the swirling flow velocity in the SEN increase with the increase of coil current intensity. The largest swirling flow velocity in the SEN can reach about 3 m/s when coil current intensity 500 A, frequency 50 Hz. The electromagnetic swirling flow in the SEN can reduce the impinging depth of the flow and increase the upward flow. An impinging flow near the mold corner can be observed. The flow field changes mentioned above result in a uniform temperature field in the mold, increase the meniscus temperature, effectively increase the temperature at the mold corner. The divergent nozzle used in this new process also reduces the impinging depth, increases the upward flow and makes the meniscus temperature increase significantly.
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