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Träfflista för sökning "WFRF:(Yang Zhiyong) srt2:(2015-2019)"

Sökning: WFRF:(Yang Zhiyong) > (2015-2019)

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1.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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2.
  • Makafe, Gaelle G., et al. (författare)
  • Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase
  • 2019
  • Ingår i: Cell Chemical Biology. - : CELL PRESS. - 2451-9456 .- 2451-9448. ; 26:8, s. 1187-
  • Tidskriftsartikel (refereegranskat)abstract
    • There is a great need for identification and development of new anti-tuberculosis drugs with novel targets. Recent drug-discovery efforts typically focus on identifying inhibitors but not activators that perturb metabolic enzymes' functions as a means to kill Mycobacterium tuberculosis (Mtb). Here, we describe a class of quinoline compounds, Z0933/Z0930, which kill Mtb by acting as activators of glutamate kinase (GK), a previously untargeted enzyme catalyzing the first step of proline biosynthesis. We further show that Z0933/Z0930 augment proline production and induce Mtb killing via proline-derived redox imbalance and production of reactive oxygen species. This work highlights the effectiveness of gain-of-function probes against Mtb and provides a framework for the discovery of next-generation allosteric activators of GK.
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3.
  • Yang, Qingkai, et al. (författare)
  • Stress-matrix-based formation scaling control
  • 2019
  • Ingår i: Automatica. - : Elsevier BV. - 0005-1098. ; 101, s. 120-127
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper investigates the formation scaling control problem for multi-agent systems by utilizing the stress matrix associated with a universally rigid framework. Compared with the existing results on formation scaling control, we consider a more challenging scenario where only one agent has the knowledge of the desired formation size. To cope with this constraint, we first propose a distributed estimator for the remaining agents to estimate the scaling parameter. Then by employing the outputs of the estimator, we design a new class of formation scaling control algorithms for universally rigid frameworks such that the overall formation converges to the prescribed shape with the desired scaling. Numerical simulations are carried out to validate the theoretical results.
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  • Resultat 1-3 av 3

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