| 1. |
- Birney, Ewan, et al.
(author)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Journal article (peer-reviewed)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 2. |
- Liu, Bingbing, et al.
(author)
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Effects of silver films with different nano-particle sizes on SERS of single-walled carbon nanotubes
- 2005
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In: Chemical Journal of the Chinese Universities. - 0251-0790. ; 26:10, s. 1930-1933
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Journal article (peer-reviewed)abstract
- Surface-enhanced Raman scattering (SERS) spectra of single-walled carbon nanotubes (SWCNTs) on silver films with different nano-particle sizes from 20 to 100 nm deposited on quartz and glass substrates were studied systematically. The characteristic Raman spectral features of SWCNT G-band and D-band were analyzed. The two bands show a similar tendency with the change of nano-particle size of silver on quartz and glass substrates. The position and the intensity of the G-band are less sensitive to the films' silver particle sizes in the studied range, indicating that hexagonal carbon rings are stable and have a weak interaction with silver films. The shape of the D-band depends on the silver size. The smaller the silver particle size, the more the contribution of high frequency vibrations to the D-band, indicating that disorder carbon has a strong interaction with the active silver films.
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| 3. |
- Zou, Yonggang, et al.
(author)
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Raman spectroscopy study of carbon nanotube peapods excited by near-IR laser under high pressure
- 2007
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In: Physical Review B. - 0163-1829. ; 76:19, s. 195417-
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Journal article (peer-reviewed)abstract
- A resonant Raman spectroscopy study has been carried out under high pressure, using a diamond anvil cell,on carbon nanotube peapods (C60@SWNT) synthesized in high yield in our laboratory. The Raman signal wasexcited by a near IR laser (830 nm) to avoid photopolymerization of C60 and thus obtain the intrinsic vibrationalinformation on the C60 molecules in the nanotubes. It is found that the surrounding tubes create aneffective pressure on the encapsulated C60 due to tube-fullerene interactions, resulting in a shift of the intrinsicAg(2) vibrational mode to 1474 cm−1 at ambient pressure. High pressure Raman spectroscopy indicates that(C60)2 dimers form near 1 GPa, and that a further polymerization of C60 occurs near 23 GPa, creating linearchains of covalently linked C60 molecules in the tubes.
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