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- Shrine, N, et al.
(författare)
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Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
- 2023
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 55:3, s. 410-
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Tidskriftsartikel (refereegranskat)abstract
- Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.
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- Yasin, A., et al.
(författare)
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Can serious gaming tactics bolster spear-phishing and phishing resilience? : Securing the human hacking in Information Security
- 2024
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Ingår i: Information and Software Technology. - : Elsevier B.V.. - 0950-5849 .- 1873-6025. ; 170
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Tidskriftsartikel (refereegranskat)abstract
- Context: In the digital age, there is a notable increase in fraudulent activities perpetrated by social engineers who exploit individuals’ limited knowledge of digital devices. These actors strategically manipulate human psychology, targeting IT devices to gain unauthorized access to sensitive data. Objectives: Our study is centered around two distinct objectives to be accomplished through the utilization of a serious game: (i) The primary objective entails delivering training and educational content to participants with a focus on phishing attacks; (ii) The secondary objective aims to heighten participants’ awareness regarding the perils associated with divulging excessive information online. Methodology: To address these objectives, we have employed the following techniques and methods: (i) A comprehensive literature review was conducted to establish foundational knowledge in areas such as social engineering, game design, learning principles, human interaction, and game-based learning; (ii) We meticulously aligned the game design with the philosophical concept of social engineering attacks; (iii) We devised and crafted an advanced hybrid version of the game, incorporating the use of QR codes to generate game card data; (iv) We conducted an empirical evaluation encompassing surveys, observations, discussions, and URL assessments to assess the effectiveness of the proposed hybrid game version. Results: Quantitative data and qualitative observations suggest the “PhishDefend Quest” game successfully improved players’ comprehension of phishing threats and how to detect them through an interactive learning experience. The results highlight the potential of serious games to educate people about social engineering risks. Conclusion: Through the evaluation, we can readily arrive at the following conclusions: (i) Game-based learning proves to be a viable approach for educating participants about phishing awareness and the associated risks tied to the unnecessary disclosure of sensitive information online; (ii) Furthermore, game-based learning serves as an effective means of disseminating awareness among participants and players concerning prevalent phishing attacks.
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