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Träfflista för sökning "WFRF:(Yepiskoposyan Levon) srt2:(2015-2019)"

Sökning: WFRF:(Yepiskoposyan Levon) > (2015-2019)

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1.
  • Karmin, Monika, et al. (författare)
  • A recent bottleneck of Y chromosome diversity coincides with a global change in culture.
  • 2015
  • Ingår i: Genome Research. - : Cold Spring Harbor Laboratory. - 1088-9051 .- 1549-5469. ; 25:4
  • Tidskriftsartikel (refereegranskat)abstract
    • It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
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2.
  • Rasmussen, Simon, et al. (författare)
  • Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago
  • 2015
  • Ingår i: Cell. - : Elsevier. - 0092-8674. ; 163:3, s. 571-582
  • Tidskriftsartikel (refereegranskat)abstract
    • The bacteria Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of deaths in historic times. How and when it originated remains contentious. Here, we report the oldest direct evidence of Yersinia pestis identified by ancient DNA in human teeth from Asia and Europe dating from 2,800 to 5,000 years ago. By sequencing the genomes, we find that these ancient plague strains are basal to all known Yersinia pestis. We find the origins of the Yersinia pestis lineage to be at least two times older than previous estimates. We also identify a temporal sequence ofgenetic changes that lead to increased virulenceand the emergence of the bubonic plague. Our results show that plague infection was endemic in the human populations of Eurasia at least 3,000 years before any historical recordings of pandemics.
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