SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Yerby Brittany)
 

Search: WFRF:(Yerby Brittany) > A multi-center prec...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function

Karageorgis, Anastassia (author)
AstraZeneca AB,Safety and ADME Translational Sciences, Drug Safety and Metabolism, AstraZeneca, Gothenburg, Sweden.
Lenhard, Stephen C. (author)
GlaxoSmithKline,Bioimaging, Platform Technology and Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
Yerby, Brittany (author)
Amgen Incorporated,Research Imaging Sciences, Amgen, Thousand Oaks, California, United States of America.
show more...
Forsgren, Mikael (author)
Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Wolfram MathCore, Linköping, Sweden
Liachenko, Serguei (author)
National Center for Toxicological Research, Division of Neurotoxicology, United States Food and Drug Administration, Jefferson, Arkansas, United States of America.
Johansson, Edvin (author)
AstraZeneca AB,Personalised Healthcare and Biomarkers, Imaging group, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Pilling, Mark A. (author)
AstraZeneca AB,Biostatistics, Quantitative Biology, Discovery Sciences, Innovative Medicines and Early Development, AstraZeneca RandD, Cambridge, United Kingdom.
Peterson, Richard A. (author)
GlaxoSmithKline,Safety Assessment, GlaxoSmithKline, Research Triangle Park, Durham, North Carolina, United States of America.
Yang, Xi (author)
National Center for Toxicological Research, Division of Systems Biology, United States Food and Drug Administration, Jefferson, Arkansas, United States of America.
Williams, Dominic P. (author)
AstraZeneca AB,Safety and ADME Translational Sciences, Drug Safety and Metabolism, AstraZeneca, Cambridge, United Kingdom.
Ungersma, Sharon E. (author)
Amgen Incorporated,Research Imaging Sciences, Amgen, Thousand Oaks, California, United States of America.
Morgan, Ryan E. (author)
Amgen Incorporated,Department of Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, California, United States of America.
Brouwer, Kim L.R. (author)
The University of North Carolina at Chapel Hill,Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of N orth Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Jucker, Beat M. (author)
GlaxoSmithKline,Bioimaging, Platform Technology and Sciences, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
Hockings, Paul, 1956 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Antaros Medical, BioVenture Hub, Mölndal, Sweden.; MedTech West, Chalmers University of Technology, Gothenburg, Sweden.
show less...
AstraZeneca AB Safety and ADME Translational Sciences, Drug Safety and Metabolism, AstraZeneca, Gothenburg, Sweden (creator_code:org_t)
2018-05-17
2018
English.
In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203 .- 1932-6203. ; 13:5
Related links:
https://research.cha... (primary) (free)
show more...
https://journals.plo...
https://liu.diva-por... (primary) (Raw object)
https://doi.org/10.1...
https://research.cha...
https://urn.kb.se/re...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Drug-induced liver injury (Dili) is a leading cause of acute liver failure and transplantation. Dili can be the result of impaired hepatobiliary transporters, with altered bile formation, flow, and subsequent cholestasis. We used gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), combined with pharmacokinetic modelling, to measure hepatobiliary transporter function in vivo in rats. The sensitivity and robustness of the method was tested by evaluating the effect of a clinical dose of the antibiotic rifampicin in four different preclinical imaging centers. The mean gadoxetate uptake rate constant for the vehicle groups at all centers was 39.3 +/- 3.4 s -1 (n = 23) and 11.7 +/- 1.3 s -1 (n = 20) for the rifampicin groups. The mean gadoxetate efflux rate constant for the vehicle groups was 1.53 +/- 0.08 s -1 (n = 23) and for the rifampicin treated groups was 0.94 +/- 0.08 s -1 (n = 20). Both the uptake and excretion transporters of gadoxetate were statistically significantly inhibited by the clinical dose of rifampicin at all centers and the size of this treatment group effect was consistent across the centers. Gadoxetate is a clinically approved MRI contrast agent, so this method is readily transferable to the clinic. Conclusion: Rate constants of

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

  • PLoS ONE (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view