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Dietary (n-3) fatty...
Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans
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- Nälsén, C (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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- Vessby, Bengt (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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Berglund, L (författare)
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visa fler...
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Uusitupa, M (författare)
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Hermansen, K (författare)
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Riccardi, G (författare)
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Rivellese, A (författare)
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Storlien, L (författare)
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Erkkilä, A (författare)
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Ylä-Herttuala, S (författare)
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Tapsell, L (författare)
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- Basur, Samar (författare)
- Uppsala universitet,Enheten för klinisk näringsforskning
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visa färre...
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: Journal of Nutrition. - 0022-3166 .- 1541-6100. ; 136:5, s. 1222-1228
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- (n-3) Fatty acids are unsaturated and are therefore easily subject to oxidization; however, they have several beneficial health effects, which include protection against cardiovascular diseases. The aim of this study was to investigate whether (n-3) fatty acids, with a controlled fat quality in the background diet, affect nonenzymatic and enzymatic lipid peroxidation and antioxidant status in humans. A total of 162 men and women in a multicenter study (The KANWU study) were randomly assigned to a diet containing a high proportion of saturated fatty acids or monounsaturated fatty acids (MUFA) for 3 mo. Within each diet group, there was a second random assignment to supplementation with fish-oil capsules [3.6 g (n-3) fatty acids/d] or placebo. Biomarkers of nonenzymatic and enzymatic lipid peroxidation in vivo were determined by measuring 8-iso-prostaglandin F2α (8-iso-PGF2α) and prostaglandin F2α (PGF2α) concentrations in plasma at baseline and after 3 mo. Antioxidant status was determined by measuring plasma antioxidant capacity with an enhanced chemiluminescence assay. The plasma 8-iso-PGF2α concentration was significantly decreased after 3 mo of supplementation with (n-3) fatty acids (P = 0.015), whereas the PGF2α concentration was not affected. The antioxidant status was not affected by supplementation of (n-3) fatty acids, but was improved by the background diet with a high proportion of MUFA. We conclude that supplementation with (n-3) fatty acids decreases nonenzymatic free radical–catalyzed isoprostane formation, but does not affect cyclooxygenase-mediated prostaglandin formation.
Nyckelord
- Administration; Oral
- Comparative Study
- Diet
- Dinoprost/*blood
- Energy Intake
- F2-Isoprostanes/*blood
- Fatty Acids/administration & dosage/pharmacology
- Fatty Acids; Omega-3/administration & dosage/*pharmacology
- Female
- Humans
- Male
- Reference Values
- Research Support; Non-U.S. Gov't
Publikations- och innehållstyp
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nälsén, C
-
Vessby, Bengt
-
Berglund, L
-
Uusitupa, M
-
Hermansen, K
-
Riccardi, G
-
visa fler...
-
Rivellese, A
-
Storlien, L
-
Erkkilä, A
-
Ylä-Herttuala, S
-
Tapsell, L
-
Basur, Samar
-
visa färre...
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Uppsala universitet