| 1. |
- Rasanen, J. E., et al.
(författare)
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5-aminolaevulinic acid nanoemulsion is more effective than methyl-5-aminolaevulinate in daylight photodynamic therapy for actinic keratosis: a nonsponsored randomized double-blind multicentre trial
- 2019
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Ingår i: British Journal of Dermatology. - : Oxford University Press (OUP). - 0007-0963 .- 1365-2133. ; 181:2, s. 265-274
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Tidskriftsartikel (refereegranskat)abstract
- Background Daylight photodynamic therapy (DL-PDT) with methyl-5-aminolaevulinate (MAL) is an effective treatment for mild and moderate actinic keratosis (AK). Objectives To assess the clinical efficacy, tolerability and cost-effectiveness of 5-aminolaevulinic acid nanoemulsion (BF-200 ALA) compared with MAL in DL-PDT for grade I-II AKs. Methods This nonsponsored, prospective randomized double-blind multicentre trial included 69 patients with 767 grade I-II AKs located symmetrically on the face or scalp. A single DL-PDT was given in a randomized split-face design. The primary outcome was clearance of the AKs at 12 months as assessed by a blinded observer. The secondary outcomes were pain, treatment reactions, cosmetic outcome and the cost-effectiveness of the therapy. Results In the per-patient (half-face) analysis, clearance was better for the BF-200 ALA sides than for those treated with MAL (P = 0 center dot 008). In total, BF-200 ALA cleared 299/375 AKs (79 center dot 7%) and MAL 288/392 (73 center dot 5%) (P = 0 center dot 041). The treatment was practically painless with both photosensitizers, the mean pain visual analogue scale being 1 center dot 51 for BF-200 ALA and 1 center dot 35 for MAL (P = 0 center dot 061). Twenty-six patients had a stronger skin reaction on the BF-200 ALA side, seven on the MAL side and 23 displayed no difference (P = 0 center dot 001). The cosmetic outcome was excellent or good in > 90% of cases with both photosensitizers (P = 1 center dot 000). The cost-effectiveness plane showed that the costs of DL-PDT were similar for both photosensitizers, but the effectiveness was slightly higher for BF-200 ALA. Conclusions Our results indicate that BF-200 ALA is more effective than MAL in DL-PDT for grade I-II AKs. BF-200 ALA provides slightly better value for money than MAL.
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| 2. |
- Autioniemi, J, et al.
(författare)
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Intelligent Road
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Project Intelligent Road is a common effort of four main partners: Rovaniemi University of Applied Sciences (RAMK), Luleå Technical University (LTU), Finnish Meteorological Institute (FMI), Kaakkois-Suomen ELY-keskus (KaS ELY) – and representatives of business sector of the region. The overall objective of the project is to support the development of business community in Northern Scandinavian region by testing and improvement of existing innovative products concerned with road safety provision in Nordic weather conditions. The specific objective of the project is to create a demo of sustainable and marketable Intelligent Road System providing location-based short-term road weather information to the road user passing by the area. Target Groups, which are directly and positively affected by the project are businesses and above mentioned project partners. All these actors have exclusive know-how in the area and are each equally important for the implementation of the project and its success. Final beneficiaries of this project are business community of the Northern Scandinavian Region; Ministry of Transport and Communications of Finland, represented by KaS ELY and Finnish Transport Safety Agency; Swedish Ministry of Enterprise, Energy and Communications; and of course local municipalities, as Luleå Municipality, and road users.
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