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| 2. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 5. |
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| 6. |
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| 7. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 8. |
- Conti, David, V, et al.
(författare)
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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- 2021
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Ingår i: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 53:1, s. 65-75
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Tidskriftsartikel (refereegranskat)abstract
- Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries.
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| 9. |
- Hassanein, M. F., et al.
(författare)
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Small-scale laterally-unrestrained corrugated web girders: (II) Parametric studies and LTB design
- 2022
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Ingår i: Thin-Walled Structures. - : Elsevier BV. - 0263-8231. ; 180
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Tidskriftsartikel (refereegranskat)abstract
- As shown in the companion paper, innovative tests of corrugated web girders (CWGs) were performed followed by validation of the finite element (FE) model. Accordingly, this paper continues investigating the lateral–torsional buckling of small-scale corrugated web girders through parametric studies. This is to expand the available data required to unveil their behaviour and strength. The layout of the tested girders is considered herein, where the webs of small corrugation dimensions are under pure bending moment with symmetrical boundary conditions. This study deals with the linear and nonlinear buckling analyses of the lateral–torsional buckling (LTB) of CWGs using ABAQUS software. Accordingly, 108 models are conducted, considering the effects of the girder length, web overall dimensions, corrugation dimensions, flange dimensions and different steel grades. The results show that increasing the girder length decreases consequently the ultimate flexural strength and stiffness of CWGs. With regard to the web overall dimensions, increasing the web depth is found to have a significant effect on the strength of CWGs in contrast to the effect of the web thickness value, which has insignificant effect on strength. Furthermore, the results revealed that increasing the flange dimensions increases subsequently the strengths of CWGs. In addition, it is noted that the lower the steel grade, the more effectively the material is used especially for girders failing elastically. Additionally, the critical and design LTB strengths of small-scale CWGs with small corrugation dimensions are evaluated. The comparisons show that the critical LTB stress requires modifications to accord well with FE results. Furthermore, comparisons of the ultimate FE strengths with those of Lindner's equation (1990), EC3 (2004) and AISC (2010) are provided. The comparisons exhibit that the predictions of Lindner's equation (1990) are suitable, while the predictions of EC3 (2004) and AISC (2010) are highly conservative. Therefore, modifications are made for EC3 (2004) and AISC (2010) design models to provide more appropriate design strengths for CWGs with small corrugation dimensions for use in buildings.
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| 10. |
- Kim, Min Seo, et al.
(författare)
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Global burden of peripheral artery disease and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
- 2023
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Ingår i: The Lancet Global Health. - : Elsevier. - 2214-109X. ; 11:10, s. E1553-E1565
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Tidskriftsartikel (refereegranskat)abstract
- Background: Peripheral artery disease is a growing public health problem. We aimed to estimate the global disease burden of peripheral artery disease, its risk factors, and temporospatial trends to inform policy and public measures.Methods: Data on peripheral artery disease were modelled using the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2019 database. Prevalence, disability-adjusted life years (DALYs), and mortality estimates of peripheral artery disease were extracted from GBD 2019. Total DALYs and age-standardised DALY rate of peripheral artery disease attributed to modifiable risk factors were also assessed.Findings: In 2019, the number of people aged 40 years and older with peripheral artery disease was 113 million (95% uncertainty interval [UI] 99 center dot 2-128 center dot 4), with a global prevalence of 1 center dot 52% (95% UI 1 center dot 33-1 center dot 72), of which 42 center dot 6% was in countries with low to middle Socio-demographic Index (SDI). The global prevalence of peripheral artery disease was higher in older people, (14 center dot 91% [12 center dot 41-17 center dot 87] in those aged 80-84 years), and was generally higher in females than in males. Globally, the total number of DALYs attributable to modifiable risk factors in 2019 accounted for 69 center dot 4% (64 center dot 2-74 center dot 3) of total peripheral artery disease DALYs. The prevalence of peripheral artery disease was highest in countries with high SDI and lowest in countries with low SDI, whereas DALY and mortality rates showed U-shaped curves, with the highest burden in the high and low SDI quintiles.Interpretation: The total number of people with peripheral artery disease has increased globally from 1990 to 2019. Despite the lower prevalence of peripheral artery disease in males and low-income countries, these groups showed similar DALY rates to females and higher-income countries, highlighting disproportionate burden in these groups. Modifiable risk factors were responsible for around 70% of the global peripheral artery disease burden. Public measures could mitigate the burden of peripheral artery disease by modifying risk factors.
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