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Träfflista för sökning "WFRF:(Yousuf S) srt2:(2015-2019)"

Sökning: WFRF:(Yousuf S) > (2015-2019)

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  • Baltzell, A, et al. (författare)
  • Theory to Practice to Enhance Performance
  • 2019
  • Ingår i: Proceedings of The 15th European Congress of Sport Psychology (FEPSAC).
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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5.
  • Haridass, Isha N., et al. (författare)
  • Cellular metabolism and pore lifetime of human skin following microprojection array mediation
  • 2019
  • Ingår i: Journal of Controlled Release. - : ELSEVIER SCIENCE BV. - 0168-3659 .- 1873-4995. ; 306, s. 59-68
  • Tidskriftsartikel (refereegranskat)abstract
    • Skin-targeting microscale medical devices are becoming popular for therapeutic delivery and diagnosis. We used cryo-SEM, fluorescence lifetime imaging microscopy (FLIM), autofluorescence imaging microscopy and inflammatory response to study the puncturing and recovery of human skin ex vivo and in vivo after discretised puncturing by a microneedle array (Nanopatch (R)). Pores induced by the microprojections were found to close by similar to 25% in diameter within the first 30 min, and almost completely close by similar to 6 h. FLIM images of ex vivo viable epidermis showed a stable fluorescence lifetime for unpatched areas of similar to 1000 ps up to 24 h. Only the cells in the immediate puncture zones (in direct contact with projections) showed a reduction in the observed fluorescence lifetimes to between similar to 518-583 ps. The ratio of free-bound NAD(P)H (alpha 1/alpha 2) in unaffected areas of the viable epidermis was similar to 2.5-3.0, whereas the ratio at puncture holes was almost double at similar to 4.2-4.6. An exploratory pilot in vivo study also suggested similar closure rate with histamine administration to the forearms of human volunteers after Nanopatch (R) treatment, although a prolonged inflammation was observed with Tissue Viability Imaging. Overall, this work shows that the pores created by the microneedle-type medical device, Nanopatch (R), are transient, with the skin recovering rapidly within 1-2 days in the epidermis after application.
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