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- Wadelius, Mia, et al.
(författare)
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Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors
- 2004
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Ingår i: The Pharmacogenomics Journal. - : Springer Science and Business Media LLC. - 1470-269X .- 1473-1150. ; 4:1, s. 40-8
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Tidskriftsartikel (refereegranskat)abstract
- The required dose of the oral anticoagulant warfarin varies greatly, and overdosing often leads to bleeding. Warfarin is metabolised by cytochrome P450 enzymes CYP2C9, CYP1A2 and CYP3A. The target cell level of warfarin may be dependent on the efflux pump P-glycoprotein, encoded by the adenosine triphosphate-binding cassette gene ABCB1 (multidrug resistance gene 1). Genetic variability in CYP2C9, CYP3A5 and ABCB1 was analysed in 201 stable warfarin-treated patients using solid-phase minisequencing, pyrosequencing and SNaPshot. CYP2C9 variants, age, weight, concurrent drug treatment and indication for treatment significantly influenced warfarin dosing in these patients, explaining 29% of the variation in dose. CYP3A5 did not affect warfarin dosing. An ABCB1 haplotype containing the exon 26 3435T variant was over-represented among low-dose patients. Thirty-six patients with serious bleeding complications had higher prothrombin time international normalised ratios than 189 warfarin-treated patients without serious bleeding, but there were no significant differences in CYP2C9, CYP3A5 or ABCB1 genotypes and allelic variants.
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| 2. |
- Zhang, Q., et al.
(författare)
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Sensors' network and its application in the intelligent storage security
- 2004
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Ingår i: UNMANNED/UNATTENDED SENSORS AND SENSOR NETWORKS. - : SPIE. - 0819455644 ; , s. 255-264
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Konferensbidrag (refereegranskat)abstract
- Intelligent storage systems run on different advanced technologies, such as linear layout, business intelligence and data mining. Security, the basic desire of the storage system, has been focused on with the indraught of multimedia communication technology and sensors' network. Along with the developing of science and the social demands, multifarious alarming system has been designed and improved to be intelligentized, modularized and have network connections. It is of great moment to make the storage, and further more, the logistics system more and more efficient and perfect with modern science and technology. Diversified information on the spot should be caught by different kinds of sensors. Those signals are treated and communicated to the control center to give the further actions. For fire-proofing, broad-spectrum gas sensors, fume sensors, flame sensors and temperature sensors are used to catch the information in their own ways. Once the fire is taken somewhere, the sensors work by the fume, temperature, and flame as well as gas immediately. Meanwhile the intelligent control system starts. It passes the tidings to the center unit. At the same time, it sets those movable walls on to work quickly to obstruct the fire's spreading. While for guarding the warehouse against theft, cut-off sensors, body sensors, photoelectric sensors, microwave sensors and closed-circuit television as well as electronic clocks are available to monitor the warehouse reasonably. All of those sensors work in a net way. The intelligent control system is made with a digital circuit instead of traditional switch one. This system can work in a better way in many cases. Its reliability is high and the cost is low.
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