| 1. |
- Hoever, P., et al.
(författare)
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Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial
- 2012
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Ingår i: Clinical pharmacology and therapeutics. - : Springer Science and Business Media LLC. - 1532-6535 .- 0009-9236. ; 91:6, s. 975-985
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Tidskriftsartikel (refereegranskat)abstract
- The orexin system is a key regulator of sleep and wakefulness. In a multicenter, double-blind, randomized, placebo-controlled, two-way crossover study, 161 primary insomnia patients received either the dual orexin receptor antagonist almorexant, at 400, 200, 100, or 50 mg in consecutive stages, or placebo on treatment nights at 1-week intervals. The primary end point was sleep efficiency (SE) measured by polysomnography; secondary end points were objective latency to persistent sleep (LPS), wake after sleep onset (WASO), safety, and tolerability. Dose-dependent almorexant effects were observed on SE, LPS, and WASO. SE improved significantly after almorexant 400 mg vs. placebo (mean treatment effect 14.4%; P < 0.001). LPS (-18 min (P = 0.02)) and WASO (-54 min (P < 0.001)) decreased significantly at 400 mg vs. placebo. Adverse-event incidence was dose-related. Almorexant consistently and dose-dependently improved sleep variables. The orexin system may offer a new treatment approach for primary insomnia.
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| 2. |
- Glantz, H, et al.
(författare)
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Occurrence and predictors of obstructive sleep apnea in a revascularized coronary artery disease cohort
- 2013
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Ingår i: Annals of the American Thoracic Society. - : American Thoracic Society. - 2329-6933 .- 2325-6621. ; 10:4, s. 350-356
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Tidskriftsartikel (refereegranskat)abstract
- Background: Knowledge about the prevalence of obstructive sleep apnea (OSA) in coronary artery disease (CAD) is insufficient. The aim of the current report was to evaluate the occurrence and predictors of OSA among revascularized patients with CAD within the framework of a randomized controlled trial (Randomized Intervention with CPAP in Coronary Artery Disease and Sleep Apnea [RICCADSA]), evaluating the impact of continuous positive airway pressure on cardiovascular outcomes in CAD patients with OSA. Material and Methods: All patients undergoing percutaneous coronary intervention or coronary artery bypass grafting between September 2005 and November 2010 (n = 1,291) were invited to participate. Anthropometrics and medical history were obtained, ambulatory sleep recording was performed, and all subjects completed the Epworth Sleepiness Scale (ESS) questionnaire. Results: In total, 662 patients participated in the sleep study. OSA, defined as an apnea–hypopnea index equal to or greater than 15/hour, was found among 422 (63.7%). The prevalence of hypertension was 55.9%; obesity (body mass index ≥ 30 kg/m2), 25.2%; diabetes mellitus, 22.1%; and current smoking, 18.9%. The patients with CAD who did not participate in the study demonstrated an almost similar anthropometric and clinical profile compared with the studied group. The majority (61.8%) of the patients with OSA were nonsleepy (ESS score < 10). Patients with OSA had a higher prevalence of obesity, hypertension, diabetes mellitus, and history of atrial fibrillation, whereas current smoking was more common in the non-OSA group. Age, male sex, body mass index, and ESS score, but not comorbidities, were independent predictors of OSA. Conclusions: The occurrence of unrecognized OSA in this revascularized CAD cohort was higher than previously reported. We suggest that OSA should be considered in the secondary prevention protocols in CAD. Read More: http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201211-106OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed&
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| 3. |
- Ozcelikkale, Ayca, 1982, et al.
(författare)
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Average error in recovery of sparse signals and discrete fourier transform | Seyrek i̇şaretleri̇n geri̇ kazaniminda ortalama hata ve ayrik fouri̇er dönüşümü
- 2012
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Ingår i: 2012 20th Signal Processing and Communications Applications Conference, SIU 2012, Proceedings.
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Konferensbidrag (refereegranskat)abstract
- In compressive sensing framework it has been shown that a sparse signal can be successfully recovered from a few random measurements. The Discrete Fourier Transform (DFT) is one of the transforms that provide the best performance guarantees regardless of which components of the signal are nonzero. This result is based on the performance criterion of signal recovery with high probability. Whether the DFT is the optimum transform under average error criterion, instead of high probability criterion, has not been investigated. Here we consider this optimization problem. For this purpose, we model the signal as a random process, and propose a model where the covariance matrix of the signal is used as a measure of sparsity. We show that the DFT is, in general, not optimal despite numerous results that suggest otherwise. © 2012 IEEE.
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| 4. |
- Ozcelikkale, Ayca, 1982, et al.
(författare)
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Unitary Precoding and Basis Dependency of MMSE Performance for Gaussian Erasure Channels
- 2014
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Ingår i: IEEE Transactions on Information Theory. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9448 .- 1557-9654. ; 60:11, s. 7186-7203
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Tidskriftsartikel (refereegranskat)abstract
- We consider the transmission of a Gaussian vector source over a multidimensional Gaussian channel where a random or a fixed subset of the channel outputs are erased. Within the setup where the only encoding operation allowed is a linear unitary transformation on the source, we investigate the minimum mean-square error (MMSE) performance, both in average, and also in terms of guarantees that hold with high probability as a function of the system parameters. Under the performance criterion of average MMSE, necessary conditions that should be satisfied by the optimal unitary encoders are established and explicit solutions for a class of settings are presented. For random sampling of signals that have a low number of degrees of freedom, we present MMSE bounds that hold with high probability. Our results illustrate how the spread of the eigenvalue distribution and the unitary transformation contribute to these performance guarantees. The performance of the discrete Fourier transform (DFT) is also investigated. As a benchmark, we investigate the equidistant sampling of circularly wide-sense stationary signals, and present the explicit error expression that quantifies the effects of the sampling rate and the eigenvalue distribution of the covariance matrix of the signal. These findings may be useful in understanding the geometric dependence of signal uncertainty in a stochastic process. In particular, unlike information theoretic measures such as entropy, we highlight the basis dependence of uncertainty in a signal with another perspective. The unitary encoding space restriction exhibits the most and least favorable signal bases for estimation.
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