| 1. |
- Saidas Nair, K, et al.
(författare)
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Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice
- 2011
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Ingår i: NATURE GENETICS. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 43:6, s. 579-U118
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Tidskriftsartikel (refereegranskat)abstract
- Angle-closure glaucoma (ACG) is a subset of glaucoma affecting 16 million people(1-3). Although 4 million people are bilaterally blind from ACG(4,5), the causative molecular mechanisms of ACG remain to be defined. High intraocular pressure induces glaucoma in ACG. High intraocular pressure traditionally was suggested to result from the iris blocking or closing the angle of the eye, thereby limiting aqueous humor drainage. Eyes from individuals with ACG often have a modestly decreased axial length, shallow anterior chamber and relatively large lens, features that predispose to angle closure(6). Here we show that genetic alteration of a previously unidentified serine protease (PRSS56) alters axial length and causes a mouse phenotype resembling ACG. Mutations affecting this protease also cause a severe decrease of axial length in individuals with posterior microphthalmia. Together, these data suggest that alterations of this serine protease may contribute to a spectrum of human ocular conditions including reduced ocular size and ACG.
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| 2. |
- Fröjdh, Erik, et al.
(författare)
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Probing Defects in a Small Pixellated CdTe Sensor Using an Inclined Mono Energetic X-Ray Micro Beam
- 2013
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Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 60:4, s. 2864-2869
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Tidskriftsartikel (refereegranskat)abstract
- High quantum efficiency is important in X-ray imaging applications. This means using high-Z sensor materials. Unfortunately many of these materials suffer from defects that cause non-ideal charge transport. In order to increase the understanding of these defects, we have mapped the 3D response of a number of defects in two 1 mm thick CdTe sensors with different pixel sizes (55 mu m and 110 mu m) using a monoenergetic microbeam at 79 keV. The sensors were bump bonded to Timepix read out chips. Data was collected in photon counting as well as time-over-thresholdmode. The time-over-thresholdmode is a very powerful tool to investigate charge transport properties and fluorescence in pixellated detectors since the signal from the charge that each photon deposits in each pixel can be analyzed. Results show distorted electrical field around the defects, indications of excess leakage current and large differences in behavior between electron collection and hole collection mode. The experiments were carried out on the Extreme Conditions Beamline I15 at Diamond Light Source.
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| 3. |
- Svensson, Bertil, 1948-, et al.
(författare)
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A running leap for embedded signal processing to future parallel platforms
- 2014
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Ingår i: WISE 2014 - Proceedings of the 2014 ACM International Workshop on Long-Term Industrial Collaboration on Software Engineering, Co-located with ASE 2014. - New York, NY, USA : Association for Computing Machinery, Inc. - 9781450330459 ; , s. 35-42
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Konferensbidrag (refereegranskat)abstract
- This paper highlights the collaboration between industry and academia in research. It describes more than two decades of intensive development and research of new hardware and software platforms to support innovative, high-performance sensor systems with extremely high demands on embedded signal processing capability. The joint research can be seen as the run before a necessary jump to a new kind of computational platform based on parallelism. The collaboration has had several phases, starting with a focus on hardware, then on efficiency, later on software development, and finally on taking the jump and understanding the expected future. In the first part of the paper, these phases and their respective challenges and results are described. Then, in the second part, we reflect upon the motivation for collaboration between company and university, the roles of the partners, the experiences gained and the long-term effects on both sides.
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| 4. |
- T, Schleyer, et al.
(författare)
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Advancing oral medicine through informatics and information technology: a proposed framework and strategy.
- 2011
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Ingår i: Oral diseases. - : Wiley. - 1354-523X. ; 17:Suppl 1, s. 85-94
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Forskningsöversikt (refereegranskat)abstract
- Abstract The implementation of information technology in healthcare is a significant focus for many nations around the world. However, information technology support for clinical care, research and education in oral medicine is currently poorly developed. This situation hampers our ability to transform oral medicine into a 'learning healthcare discipline' in which the divide between clinical practice and research is diminished and, ultimately, eliminated. This paper reviews the needs of and requirements for information technology support of oral medicine and proposes an agenda designed to meet those needs. For oral medicine, this agenda includes analyzing and reviewing current clinical and documentation practices, working toward progressively standardizing clinical data, and helping define requirements for oral medicine systems. IT professionals can contribute by conducting baseline studies about the use of electronic systems, helping develop controlled vocabularies and ontologies, and designing, implementing, and evaluating novel systems centered on the needs of clinicians, researchers and educators. Successfully advancing IT support for oral medicine will require close coordination and collaboration among oral medicine professionals, information technology professionals, system vendors, and funding agencies. If current barriers and obstacles are overcome, practice and research in oral medicine stand ready to derive significant benefits from the application of information technology.
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