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Numrering	Referens	Omslagsbild	Hitta
1.	Kirchhof, P, et al. (författare) 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS 2016 Ingår i: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. - : Oxford University Press (OUP). - 1532-2092. ; 18:11, s. 1609-1678 Tidskriftsartikel (refereegranskat)
2.	Cadrin-Tourigny, Julia, et al. (författare) A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy 2019 Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 40:23, s. 1850-1858 Tidskriftsartikel (refereegranskat)abstract AIMS: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. METHODS AND RESULTS: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interquartile range 2.44-9.33) years of follow-up, 146 (27.7%) experienced sustained VA, defined as SCD, aborted SCD, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator (ICD) therapy. A prediction model estimating annual VA risk was developed using Cox regression with internal validation. Eight potential predictors were pre-specified: age, sex, cardiac syncope in the prior 6 months, non-sustained ventricular tachycardia, number of premature ventricular complexes in 24 h, number of leads with T-wave inversion, and right and left ventricular ejection fractions (LVEFs). All except LVEF were retained in the final model. The model accurately distinguished patients with and without events, with an optimism-corrected C-index of 0.77 [95% confidence interval (CI) 0.73-0.81] and minimal over-optimism [calibration slope of 0.93 (95% CI 0.92-0.95)]. By decision curve analysis, the clinical benefit of the model was superior to a current consensus-based ICD placement algorithm with a 20.6% reduction of ICD placements with the same proportion of protected patients (P < 0.001). CONCLUSION: Using the largest cohort of patients with ARVC and no prior VA, a prediction model using readily available clinical parameters was devised to estimate VA risk and guide decisions regarding primary prevention ICDs (www.arvcrisk.com).

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Sharma, S. (1); Filippatos, G (1); Platonov, Pyotr G (1); Ruschitzka, F (1); Popescu, BA (1); Diener, HC (1); visa fler...; Agewall, S (1); Atar, D (1); De Caterina, R (1); Lip, GYH (1); Camm, J (1); Zamorano, JL (1); Ahlsson, A (1); Krahn, Andrew D. (1); Casadei, B (1); Cadrin-Tourigny, Jul ... (1); Tadros, Rafik (1); Oldgren, J. (1); Kirchhof, P. (1); Ponikowski, P (1); Khairy, Paul (1); Voors, AA (1); Asselbergs, Folkert ... (1); Wilde, Arthur A. M. (1); Svensson, Anneli (1); McMurray, J. (1); Kotecha, D (1); Haugaa, Kristina H. (1); Rosenhek, R (1); Windecker, S (1); Coca, A (1); Fitzsimons, D (1); Hindricks, G (1); Zeppenfeld, Katja (1); Heidbuchel, H. (1); Manolis, A (1); Kolh, P (1); Calkins, Hugh (1); Hohnloser, SH (1); Hendriks, J (1); Savelieva, I (1); Gorenek, B (1); Vardas, P. (1); Bosman, Laurens P. (1); Nozza, Anna (1); Wang, Weijia (1); Bhonsale, Aditya (1); Bourfiss, Mimount (1); Fortier, Annik (1); Lie, Øyvind H. (1); visa färre...

Lärosäte: Linköpings universitet (1); Lunds universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

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