| 1. |
- Tian, Yu-peng, et al.
(författare)
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Synthesis, crystal structure and NLO properties of a novel ruthenium(II) complex with unusual coordination mode
- 2005
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Ingår i: Transition metal chemistry (Weinheim). - : Kluwer Academic Publishers. - 0340-4285 .- 1572-901X. ; 30:7, s. 778-785
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Tidskriftsartikel (refereegranskat)abstract
- A new Schiff base 4-[N-hydroxyethyl-N-(methyl)amino]benzaldehyde S-methyl dithiocarbazate (HL, where H is a dissociable proton) and the ruthenium complex [Ru(bpy)2L]PF6 (bpy = 2,2′-bipyridine) have been synthesized. The structural determinations of the ligand and its ruthenium complex, by X-ray crystallography, show that the ligand is coordinated as a monoanionic bidentate N, S-donor, forming a four-member chelate ring with a bite angle of 65.91°. The complex shows intense MLCT transitions in the visible region. Fluorescent and electrochemical properties have been also studied. The complex in DMF solution exhibited a strong two-photon absorption (t.p.a.) at 532 nm nanosecond laser pulses. The t.p.a. coefficient β, t.p.a. cross-section σ and the third-order optical nonlinearity χ(3) of the complex and the ligand have been determined by the Z-scan technique.
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| 2. |
- Bylund, Annika, et al.
(författare)
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Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo.
- 2005
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Ingår i: Experimental biology and medicine. - 1535-3702 .- 1535-3699. ; 230:3, s. 217-223
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Tidskriftsartikel (refereegranskat)abstract
- Clinical intervention studies and experimental studies with lignan-rich diets suggest that lignans may have inhibitory effects on prostate cancer, but no clinical or experimental studies with purified lignans have been published. The purpose of this study was to investigate the effect of a plant lignan 7-hydroxymatairesinol (HMR) on LNCaP human prostate cancer xenografts in athymic mice. Athymic nude male mice were injected subcutaneously with LNCaP cells. Starting 3 days after tumor cell injections, a control diet or a control diet supplemented with 0.15% or 0.30% of HMR was administered to mice and the tumor take rate and growth was observed for 9 weeks. HMR diet inhibited the growth of LNCaP tumors. Mice treated with HMR had smaller tumor volume, lower tumor take rate, increased proportion of nongrowing tumors, and higher tumor cell apoptotic index compared with controls. Furthermore, the cell proliferation index was reduced in mice receiving the 0.30% HMR diet compared with mice receiving the control diet. Our results suggest that dietary HMR started at the early phase of the tumor development inhibits the growth of the LNCaP human prostate cancer xenografts in athymic male mice.
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| 3. |
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| 4. |
- Guo, Songchang, et al.
(författare)
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Origin of mitochondrial DNA diversity of domestic yaks
- 2006
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Ingår i: BMC Evolutionary Biology. - : Springer Science and Business Media LLC. - 1471-2148. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Background: The domestication of plants and animals was extremely important anthropologically. Previous studies have revealed a general tendency for populations of livestock species to include deeply divergent maternal lineages, indicating that they were domesticated in multiple, independent events from genetically discrete wild populations. However, in water buffalo, there are suggestions that a similar deep maternal bifurcation may have originated from a single population. These hypotheses have rarely been rigorously tested because of a lack of sufficient wild samples. To investigate the origin of the domestic yak (Poephagus grunnies), we analyzed 637 bp of maternal inherited mtDNA from 13 wild yaks (including eight wild yaks from a small population in west Qinghai) and 250 domesticated yaks from major herding regions. Results: The domestic yak populations had two deeply divergent phylogenetic groups with a divergence time of > 100,000 yrs BP. We here show that haplotypes clustering with two deeply divergent maternal lineages in domesticated yaks occur in a single, small, wild population. This finding suggests that all domestic yaks are derived from a single wild gene pool. However, there is no clear correlation of the mtDNA phylogenetic clades and the 10 morphological types of sampled yaks indicating that the latter diversified recently. Relatively high diversity was found in Qinghai and Tibet around the current wild distribution, in accordance with previous suggestions that the earliest domestications occurred in this region. Conventional molecular clock estimation led to an unrealistic early dating of the start of the domestication. However, Bayesian estimation of the coalescence time allowing a relaxation of the mutation rate Conclusion: The information gathered here and the previous studies of other animals show that the demographic histories of domestication of livestock species were highly diverse despite the common general feature of deeply divergent maternal lineages. The results further suggest that domestication of local wild prey ungulate animals was a common occurrence during the development of human civilization following the postglacial colonization in different locations of the world, including the high, arid Qinghai-Tibetan Plateau.
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| 5. |
- He, Jie, et al.
(författare)
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Research on ethanol synthesis from syngas
- 2008
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Ingår i: Journal of Zhejiang University - Science A. - 1673-565X. ; 9:5, s. 714-719
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Tidskriftsartikel (refereegranskat)abstract
- It is a very fine substitutable energy technology to synthesize ethanol from biomass-derived syngas. This paper summarized the development of preparing ethanol from syngas, and especially elaborated on the research status of catalysts for the process. Based on the relative researches on the reaction mechanism, structure and performance of the catalysts, the optimumdesign of catalysts with high activity was presented in this review, which set the theoretical and application foundation for the industrial production of ethanol from syngas.
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| 6. |
- Jun, Chen, et al.
(författare)
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A Novel Acceleration Data Compression Scheme for Wireless Sensor Network Application in Fresh Food Tracking System
- 2009
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Ingår i: The Ninth International Conference on Electronic Measurement & Instruments ICEMI’2009. - : IEEE Press. - 9781424438631 ; , s. 3-1-3-5
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Konferensbidrag (refereegranskat)abstract
- An enhanced dual-layer wide area wireless sensor network (WSN) system was developed and applied in fresh food tracking application. The sensor nodes of WSN provide a set of useful measurements about the environmental conditions during the fresh food transportation. Since the 3-axis acceleration data in such application account for more than 99% out of all collected source data, we propose a novel acceleration data compression scheme for this specific application, to overcome the resource and cost limitation imposed on embedded sensing nodes and wireless communication links in WSN. According to general fresh food transport behavior pattern, the acceleration data can be extracted into three components (D waveform, A waveform and P waveform). Each component could be compressed separately according to its distinct characteristic and then packetized as an encoded frame. In this paper we examine the experimental acceleration dataset from a field test (fresh melon fruit transport from Brazil to Sweden in 20 days) as a test case. Experimental results show that a high compression ratio (around 10:1) with the acceptable distortion could be achieved, confirming the effectiveness of the compression scheme proposed in this work.
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| 7. |
- Landberg, Rikard, et al.
(författare)
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Reproducibility of plasma alkylresorcinols during a 6-week rye intervention study in men with prostate cancer
- 2009
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Ingår i: Journal of Nutrition. - : Elsevier BV. - 0022-3166 .- 1541-6100. ; 139:5, s. 975-980
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Tidskriftsartikel (refereegranskat)abstract
- Alkylresorcinols (AR), phenolic lipids exclusively present in the outer parts of wheat and rye grains, have been proposed as concentration biomarkers of whole-grain wheat and rye intake. A key feature of a good biomarker is high reproducibility, which indicates how accurately a single sample reflects the true mean biomarker concentration caused by a certain intake. In this study, the short- to medium-term reproducibility of plasma AR was determined using samples from a crossover intervention study, where men with prostate cancer (n = 17) were fed rye whole-grain/bran or refined wheat products for 6-wk periods. AR homologs C17:0 and C21:0 differed between the treatments (P < 0.001). The reproducibility determined by the intraclass correlation coefficient (ICC) was high (intervention period 1: ICC = 0.90 [95% CI = 0.82-0.98], intervention period 2: ICC = 0.88 [95% CI = 0.78-0.98]). The results show that a single fasting plasma sample could be used to estimate the mean plasma AR concentration during a 6-wk intervention period with constant intake at a precision of +/- 20% (80% CI). This suggests that the plasma AR concentration can be used as a reliable short- to medium-term biomarker for whole-grain wheat and rye under intervention conditions where intake is kept constant.
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| 8. |
- Lu, Ying-Jie, et al.
(författare)
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Interleukin-17A mediates acquired immunity to pneumococcal colonization.
- 2008
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Ingår i: PLoS pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 4:9
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Tidskriftsartikel (refereegranskat)abstract
- Although anticapsular antibodies confer serotype-specific immunity to pneumococci, children increase their ability to clear colonization before these antibodies appear, suggesting involvement of other mechanisms. We previously reported that intranasal immunization of mice with pneumococci confers CD4+ T cell-dependent, antibody- and serotype-independent protection against colonization. Here we show that this immunity, rather than preventing initiation of carriage, accelerates clearance over several days, accompanied by neutrophilic infiltration of the nasopharyngeal mucosa. Adoptive transfer of immune CD4+ T cells was sufficient to confer immunity to naïve RAG1(-/-) mice. A critical role of interleukin (IL)-17A was demonstrated: mice lacking interferon-gamma or IL-4 were protected, but not mice lacking IL-17A receptor or mice with neutrophil depletion. In vitro expression of IL-17A in response to pneumococci was assayed: lymphoid tissue from vaccinated mice expressed significantly more IL-17A than controls, and IL-17A expression from peripheral blood samples from immunized mice predicted protection in vivo. IL-17A was elicited by pneumococcal stimulation of tonsillar cells of children or adult blood but not cord blood. IL-17A increased pneumococcal killing by human neutrophils both in the absence and in the presence of antibodies and complement. We conclude that IL-17A mediates pneumococcal immunity in mice and probably in humans; its elicitation in vitro could help in the development of candidate pneumococcal vaccines.
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| 9. |
- Markljung, Ellen, et al.
(författare)
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ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth
- 2009
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Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 7:12, s. e1000256-
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Tidskriftsartikel (refereegranskat)abstract
- A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size of the heart, and fat deposition. Here, we have identified the repressor and find that the protein, named ZBED6, is previously unknown, specific for placental mammals, and derived from an exapted DNA transposon. Silencing of Zbed6 in mouse C2C12 myoblasts affected Igf2 expression, cell proliferation, wound healing, and myotube formation. Chromatin immunoprecipitation (ChIP) sequencing using C2C12 cells identified about 2,500 ZBED6 binding sites in the genome, and the deduced consensus motif gave a perfect match with the established binding site in Igf2. Genes associated with ZBED6 binding sites showed a highly significant enrichment for certain Gene Ontology classifications, including development and transcriptional regulation. The phenotypic effects in mutant pigs and ZBED6-silenced C2C12 myoblasts, the extreme sequence conservation, its nucleolar localization, the broad tissue distribution, and the many target genes with essential biological functions suggest that ZBED6 is an important transcription factor in placental mammals, affecting development, cell proliferation, and growth.
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| 10. |
- Pang, Zhibo, et al.
(författare)
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Mobile and Wide Area Deployable Sensor System for Networked Services
- 2009
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Ingår i: 2009 IEEE SENSORS. - NEW YORK : IEEE. - 9781424445486 ; , s. 1329-1332
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Konferensbidrag (refereegranskat)abstract
- A mobile and wide area deployable wireless sensor system, including hardware and software, is developed to enhance the mobility, deployment and capability of wireless sensors for networked services. Due to the dual-layer dual-directional wireless communication capability of a novel WAN-SAN coherent architecture and the removal of fix-installed gateway, all sensor nodes are remotely controllable and seamlessly integrated to internet services. Hardware modules are optimized for ultra low power and compact size. Abstract and extendable application interface is developed, based on SMS and TCP/UDP protocol, to be integrated easily into existing service systems. Hierarchical CPS-LPS Adaptive Localization, is supported based on CPS, wireless cellular ID, RFID, IR-UWB and inertial prediction. Specific data compression technique is adopted for high density data source. Finally, Fresh Food Tracking service is presented as an application example, including some field test data.
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