| 1. |
- Abazov, V. M., et al.
(författare)
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The upgraded DO detector
- 2006
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 565:2, s. 463-537
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Tidskriftsartikel (refereegranskat)abstract
- The DO experiment enjoyed a very successful data-collection run at the Fermilab Tevatron collider between 1992 and 1996. Since then, the detector has been upgraded to take advantage of improvements to the Tevatron and to enhance its physics capabilities. We describe the new elements of the detector, including the silicon microstrip tracker, central fiber tracker, solenoidal magnet, preshower detectors, forward muon detector, and forward proton detector. The uranium/liquid -argon calorimeters and central muon detector, remaining from Run 1, are discussed briefly. We also present the associated electronics, triggering, and data acquisition systems, along with the design and implementation of software specific to DO.
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| 2. |
- Hu, Jinhong, et al.
(författare)
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Safety and immunogenicity of a malaria vaccine, Plasmodium falciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adults
- 2008
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Ingår i: PLOS ONE. - : PLOS. - 1932-6203. ; 3:4
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The P. falciparum chimeric protein 2.9 (PfCP-2.9) consisting of the sequences of MSP1-19 and AMA-1 (III) is a malaria vaccine candidate that was found to induce inhibitory antibodies in rabbits and monkeys. This was a phase I randomized, single-blind, placebo-controlled, dose-escalation study to evaluate the safety and immunogenicity of the PfCP-2.9 formulated with a novel adjuvant Montanide ISA720. Fifty-two subjects were randomly assigned to 4 dose groups of 10 participants, each receiving the test vaccine of 20, 50, 100, or 200 microg respectively, and 1 placebo group of 12 participants receiving the adjuvant only.METHODS AND FINDINGS: The vaccine formulation was shown to be safe and well-tolerated, and none of the participants withdrew. The total incidence of local adverse events (AEs) was 75%, distributed among 58% of the placebo group and 80% of those vaccinated. Among the vaccinated, 65% had events that were mild and 15% experienced moderate AEs. Almost all systemic adverse reactions observed in this study were graded as mild and required no therapy. The participants receiving the test vaccine developed detectable antibody responses which were boosted by the repeated vaccinations. Sixty percent of the vaccinated participants had high ELISA titers (>1:10,000) of antigen-specific antibodies which could also recognize native parasite proteins in an immunofluorescence assay (IFA).CONCLUSION: This study is the first clinical trial for this candidate and builds on previous investigations supporting PfCP-2.9/ISA720 as a promising blood-stage malaria vaccine. Results demonstrate safety, tolerability (particularly at the lower doses tested) and immunogenicity of the formulation. Further clinical development is ongoing to explore optimizing the dose and schedule of the formulation to decrease reactogenicity without compromising immunogenicity.TRIAL REGISTRATION: Chinese State Food and Drug Administration (SFDA) 2002SL0046; Controlled-Trials.com ISRCTN66850051 [66850051].
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| 3. |
- Hu, Yunfeng, et al.
(författare)
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Spatial-Temporal Pattern of GIMMS NDVI and Its Dynamics in Mongolian Plateau
- 2008
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Ingår i: International Workshop on Earth Observation and Remote Sensing Applications, EORSA2008. - NEW YORK : IEEE. - 9781424423934 ; , s. 119-124
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Konferensbidrag (refereegranskat)abstract
- The physical geography of Mongolian Plateau plays an important role in the East Asian climate ecology system. In this research, GIMMS NDVI, the third generation of NDVI dataset, was processed using the MVC method first, then the spatial-temporal patterns of GIMMS NDVI in Mongolian Plateau during 1982-2003 was investigated, and the transect from Tariat to Xilin Gol was also selected to analyze the NDVI dynamic processes in detail. The results demonstrated that: 1) The general spatial distribution pattern of NDVI showed a clear spatial differentiation. The high value pixels were mainly distributed in the east and north of Mongolian Plateau with forest and meadow steppe land cover, while the low value pixels were mainly distributed in the west and centre part of Mongolian Plateau with desert and Gobi land cover. However, the annual NDVI variability was relative small either in the high-covered regions (i.e. forest, forest steppe, and meadow steppe) or in low-covered regions (i.e. steppe desert, desert and Gobi), while the region with typical steppe normally had higher annual NDVI variability; 2) During 1982-2003, the dynamic evolution process of NDVI in Mongolian Plateau also showed an evident spatial differentiation. About 12.4% of total area featured a significant increase, 4.8% of total area featured an increase but without significance, and 9.3% of total area featured decrease without significance. The other part, about 73.5% of total area, had no obvious change. The NDVI increased significantly in the South-East, South and of Mongolian Plateau, while it decreased in the North-East and North of Mongolian Plateau. Further, the NDVI-increased regions were those typical steppe and farming-pastoral regions before, while the NDVI-decreased regions were those well-covered forest, forest steppe and meadow steppe regions before.
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| 4. |
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| 5. |
- Abazov, V. M., et al.
(författare)
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Combined D0 measurements constraining the CP-violating phase and width difference in the B-s(0) system
- 2007
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 76:5, s. 057101-
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Tidskriftsartikel (refereegranskat)abstract
- We combine the D0 measurement of the width difference between the light and heavy B-s(0) mass eigenstates and of the CP-violating mixing phase determined from the time-dependent angular distributions in the B-s(0)-> J/psi phi decays along with the charge asymmetry in semileptonic decays also measured with the D0 detector. With the additional constraint from the world average of the flavor-specific B-s(0) lifetime, we obtain Delta Gamma(s)equivalent to(Gamma(L)-Gamma(H))=0.13 +/- 0.09 ps(-1) and vertical bar phi(s)vertical bar=0.70(-0.47)(+0.39) or Delta Gamma(s)=-0.13 +/- 0.09 ps(-1) and vertical bar phi(s)vertical bar=2.44(-0.39)(+0.47). The data sample corresponds to an integrated luminosity of 1.1 fb(-1) accumulated with the D0 detector at the Fermilab Tevatron Collider.
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| 6. |
- Abazov, V. M., et al.
(författare)
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Direct observation of the strange b baryon Xi(-)(b)
- 2007
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 99:5, s. 052001-
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Tidskriftsartikel (refereegranskat)abstract
- We report the first direct observation of the strange b baryon Xi(-)(b)(Xi) over bar (+)(b)). We reconstruct the decay Xi(-)(b)-->J/psi Xi(-), with J/psi-->mu(+)mu(-), and Xi(-)-->Lambda pi(-)-->p pi(-)pi(-) in p (p) over bar collisions at root s = 1.96 TeV. Using 1.3 fb(-1) of data collected by the D0 detector, we observe 15.2 +/- 4.4(stat)(-0.4)(+1.9)(syst) Xi(-)(b) candidates at a mass of 5.774 +/- 0.011(stat) +/- 0.015(syst) GeV. The significance of the observed signal is 5.5 sigma, equivalent to a probability of 3.3 x 10(-8) of it arising from a background fluctuation. Normalizing to the decay Lambda(b)-->J/psi Lambda, we measure the relative rate sigma(Xi(-)(b))xB(Xi(-)(b)-->J/psi Xi)/ sigma(Lambda(b))xB(Lambda(b)-->J/psi Lambda) = 0.28 +/- 0.09(stat)(-0.08)(+0.09)(syst).
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| 7. |
- Abazov, V. M., et al.
(författare)
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Evidence for production of single top quarks and first direct measurement of vertical bar V-tb vertical bar
- 2007
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:18, s. 181802-
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Tidskriftsartikel (refereegranskat)abstract
- The D0 Collaboration presents first evidence for the production of single top quarks at the Fermilab Tevatron < p(p)over bar > collider. Using a 0.9 fb(-1) dataset, we apply a multivariate analysis to separate signal from background and measure sigma(< p(p)over bar >-> tb+X,tqb+X)=4.9 +/- 1.4 pb. The probability to measure a cross section at this value or higher in the absence of a signal is 0.035%, corresponding to a 3.4 standard deviation significance. We use the cross section measurement to directly determine the Cabibbo-Kobayashi-Maskawa matrix element that describes the Wtb coupling and find 0.68 <= 1 at 95% C.L. within the standard model.
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| 8. |
- Abazov, V. M., et al.
(författare)
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Experimental discrimination between charge 2e/3 top quark and charge 4e/3 exotic quark production scenarios
- 2007
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:4, s. 041801-
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Tidskriftsartikel (refereegranskat)abstract
- We present the first experimental discrimination between the 2e/3 and 4e/3 top quark electric charge scenarios, using top quark pairs (t (t) over bar) produced in p (p) over bar collisions at root s =1.96 TeV by the Fermilab Tevatron Collider. We use 370 pb(-1) of data collected by the D0 experiment and select events with at least one high transverse momentum electron or muon, high transverse energy imbalance, and four or more jets. We discriminate between b- and (b) over bar -quark jets by using the charge and momenta of tracks within the jet cones. The data are consistent with the expected electric charge, |q|=2e/3. We exclude, at the 92% C.L., that the sample is solely due to the production of exotic quark pairs Q (Q) over bar with |q|=4e/3. We place an upper limit on the fraction of Q (Q) over bar pairs rho < 0.80 at the 90% C.L.
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| 9. |
- Abazov, V. M., et al.
(författare)
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Lifetime difference and CP-violating phase in the B-s(0) system
- 2007
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:12, s. 121801-
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Tidskriftsartikel (refereegranskat)abstract
- From an analysis of the decay B-s(0)-> J/psi phi, we obtain the width difference between the light and heavy mass eigenstates Delta Gamma equivalent to(Gamma(L)-Gamma(H))=0.17 +/- 0.09(stat)+/- 0.02(syst) ps(-1) and the CP-violating phase phi(s)=-0.79 +/- 0.56(stat)(-0.01)(+0.14)(syst). Under the hypothesis of no CP violation (phi(s)equivalent to 0), we obtain 1/Gamma=tau/(B-s(0))=1.52 +/- 0.08(stat)(-0.03)(+0.01)(syst) ps and Delta Gamma=0.12(-0.10)(+0.08)(stat)+/- 0.02(syst) ps(-1). The data sample corresponds to an integrated luminosity of about 1.1 fb(-1) accumulated with the D0 detector at the Fermilab Tevatron collider. This is the first direct measurement of the CP-violating mixing phase in the B-s(0) system.
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| 10. |
- Abazov, V. M., et al.
(författare)
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Limits on anomalous trilinear gauge couplings from WW -> e(+)e(-), WW -> e(+/-)mu(-/+), and WW ->mu(+)mu(-) events from pp collisions at root s=1.96 TeV
- 2006
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Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998 .- 1550-2368. ; 74:5, s. 057101-
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Tidskriftsartikel (refereegranskat)abstract
- Limits are set on anomalous WW gamma and WWZ trilinear gauge couplings using W+W--> e(+)nu(e)e(-)(nu) over bar (e), W+W--> e(+/-)nu(e)mu(-/+)nu(mu), and W+W-->mu(+)nu(mu)mu(-)(nu) over bar (mu) events. The data set was collected by the Run II D0 detector at the Fermilab Tevatron Collider and corresponds to approximately 250 pb(-1) of integrated luminosity at root s=1.96 TeV. Under the assumption that the WW gamma couplings are equal to the WWZ couplings and using a form factor scale of Lambda=2.0 TeV, the combined 95% C.L. one-dimensional coupling limits from all three channels are -0.32
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