| 1. |
- Liu, Yang, et al.
(författare)
-
MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2
- 2019
-
Ingår i: Stem Cell Research and Therapy. - : Springer Science and Business Media LLC. - 1757-6512. ; 10:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Tendons are a crucial component of the musculoskeletal system and responsible for transmission forces derived from muscle to bone. Patients with tendon injuries are often observed with decreased collagen production and matrix degeneration, and healing of tendon injuries remains a challenge as a result of limited understanding of tendon biology. Recent studies highlight the contribution of miR-378a on the regulation gene expression during tendon differentiation. Methods: We examined the tendon microstructure and tendon repair with using miR-378a knock-in transgenic mice, and the tendon-derived stem cells were also isolated from transgenic mice to study their tenogenic differentiation ability. Meanwhile, the expression levels of tenogenic markers were also examined in mouse tendon-derived stem cells transfected with miR-378a mimics during tenogenic differentiation. With using online prediction software and luciferase reporter assay, the binding target of miR-378a was also studied. Results: Our results indicated miR-378a impairs tenogenic differentiation and tendon repair by inhibition collagen and extracellular matrix production both in vitro and in vivo. We also demonstrated that miR-378a exert its inhibitory role during tenogenic differentiation through binding at TGFβ2 by luciferase reporter assay and western blot. Conclusions: Our investigation suggests that miR-378a could be considered as a new potential biomarker for tendon injury diagnosis or drug target for a possible therapeutic approach in future clinical practice.
|
|
| 2. |
|
|
| 3. |
- Yuan, Jun, et al.
(författare)
-
Enabling low voltage losses and high photocurrent in fullerene-free organic photovoltaics
- 2019
-
Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- Despite significant development recently, improving the power conversion efficiency of organic photovoltaics (OPVs) is still an ongoing challenge to overcome. One of the prerequisites to achieving this goal is to enable efficient charge separation and small voltage losses at the same time. In this work, a facile synthetic strategy is reported, where optoelectronic properties are delicately tuned by the introduction of electron-deficient-core-based fused structure into non-fullerene acceptors. Both devices exhibited a low voltage loss of 0.57 V and high short-circuit current density of 22.0 mA cm(-2), resulting in high power conversion efficiencies of over 13.4%. These unconventional electron-deficient-core-based non-fullerene acceptors with near-infrared absorption lead to low non-radiative recombination losses in the resulting organic photovoltaics, contributing to a certified high power conversion efficiency of 12.6%.
|
|
| 4. |
- Chen, Min, et al.
(författare)
-
Highly stable and efficient all-inorganic lead-free perovskite solar cells with native-oxide passivation
- 2019
-
Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10
-
Tidskriftsartikel (refereegranskat)abstract
- There has been an urgent need to eliminate toxic lead from the prevailing halide perovskite solar cells (PSCs), but the current lead-free PSCs are still plagued with the critical issues of low efficiency and poor stability. This is primarily due to their inadequate photovoltaic properties and chemical stability. Herein we demonstrate the use of the lead-free, all-inorganic cesium tin-germanium triiodide (CsSn(0.5)Ge(0.5)l(3)) solid-solution perovskite as the light absorber in PSCs, delivering promising efficiency of up to 7.11%. More importantly, these PSCs show very high stability, with less than 10% decay in efficiency after 500 h of continuous operation in N-2 atmosphere under one-sun illumination. The key to this striking performance of these PSCs is the formation of a full-coverage, stable native-oxide layer, which fully encapsulates and passivates the perovskite surfaces. The native-oxide passivation approach reported here represents an alternate avenue for boosting the efficiency and stability of lead-free PSCs.
|
|
| 5. |
- Ren, Jiaying, et al.
(författare)
-
RFI Mitigation for UWB Radar Via Hyperparameter-Free Sparse SPICE Methods
- 2019
-
Ingår i: IEEE Transactions on Geoscience and Remote Sensing. - : IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC. - 0196-2892 .- 1558-0644. ; 57:6, s. 3105-3118
-
Tidskriftsartikel (refereegranskat)abstract
- Radio frequency interference (RFI) causes serious problems to ultrawideband (UWB) radar operations due to severely degrading radar imaging capability and target detection performance. This paper formulates proper data models and proposes novel methods for effective RFI mitigation. We first apply the single-snapshot Sparse Iterative Covariance-based Estimation (SPICE) algorithm to data from each pulse repetition interval for RFI mitigation and discuss the connection of SPICE to the l(1)-penalized least absolute deviation (l(1)-PLAD) approach. Then, we devise a modified group SPICE algorithm and we prove that it is equivalent to a special case of the l(1,2)-PLAD method. The modified group SPICE algorithm can be applied to data from a coherent processing interval for effective RFI mitigation. Both the single-snapshot SPICE and the modified group SPICE methods simultaneously exploit the sparsity properties of both RFI spectrum and UWB radar target echoes. Unlike the existing sparsity-based RFI suppression methods, such as the robust principal component analysis algorithm, the proposed methods are hyperparameter-free and therefore easier to use in practical applications. Furthermore, the fast implementation of the SPICE methods is considered by exploiting the special structures of both single-snapshot and multiple-snapshot covariance matrices. Finally, the results obtained from applying the SPICE methods to simulated data as well as measured data collected by the U.S. Army Research Laboratory synthetic aperture radar system are presented to demonstrate the effectiveness of the proposed methods.
|
|
| 6. |
|
|
| 7. |
- Yang, Jianming, et al.
(författare)
-
Extremely Low-Cost and Green Cellulose Passivating Perovskites for Stable and High-Performance Solar Cells
- 2019
-
Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 11:14, s. 13491-13498
-
Tidskriftsartikel (refereegranskat)abstract
- The fast evolution of metal halide perovskite solar cells has opened a new chapter in the field of renewable energy. High-quality perovskite films as the active layers are essential for both high efficiency and long-term stability. Here, the perovskite films with enlarged crystal grain size and decreased defect density are fabricated by introducing the extremely low-cost and green polymer, ethyl cellulose (EC), into the perovskite layer. The addition of EC triggers hydrogen bonding interactions between EC and the perovskite, passivating the charge defect traps at the grain boundaries. The long chain of EC further acts as a scaffold for the perovskite structure, eliminating the annealing-induced lattice strain during the film fabrication process. The resulting devices with the EC additive exhibit a remarkably enhanced average power conversion efficiency from 17.11 to 19.27% and an improvement of all device parameters. The hysteresis index is found to decrease by three times from 0.081 to 0.027, which is attributed to suppressed ion migration and surface charge trapping. In addition, the defect passivation by EC significantly improves the environmental stability of the perovskite films, yielding devices that retain 80% of their initial efficiency after 30 days in ambient air at 45% relative humidity, whereas the pristine devices without EC fully degrade. This work provides a low-cost and green avenue for passivating defects that improves both the efficiency and operational stability of perovskite solar cells.
|
|
