| 1. |
- Xiao, Chao, et al.
(författare)
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RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer
- 2018
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Ingår i: Cancer Science. - : Blackwell Publishing. - 1347-9032 .- 1349-7006. ; 109:4, s. 1075-1087
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Tidskriftsartikel (refereegranskat)abstract
- Radiotherapy (RT) can be used as preoperative treatment to downstage initially unresectable locally rectal carcinoma, but the radioresistance and recurrence remain significant problems. Retinoblastoma binding protein 6 (RBBP6) has been implicated in the regulation of cell cycle, apoptosis and chemoresistance both in vitro and in vivo. This study investigated whether the inhibition of RBBP6 expression would improve radiosensitivity in human colorectal cancer cells. After SW620 and HT29 cells were exposed to radiation, the levels of RBBP6 mRNA and protein increased over time in both two cells. Moreover, a significant reduction in clonogenic survival and a decrease in cell viability in parallel with an obvious increase in cell apoptosis were demonstrated in irradiated RBBP6-knockdown cells. Besides, transfection with RBBP6 shRNA improved levels of G2-M phase arrest which blocked the cells in a more radiosensitive period of the cell cycle. These observations indicated that cell cycle and apoptosis mechanisms may be connected with tumor cell survival following radiotherapy. In vivo, tumor growth rate of nude mice in RBBP6-knockdown group was significantly slower than that in other groups. These results indicated that RBBP6 overexpression could resist colorectal cancer cells against radiation by regulating cell cycle and apoptosis pathways, and inhibition of RBBP6 could enhance radiosensitivity of human colorectal cancer.
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| 2. |
- Chen, Yingxin, et al.
(författare)
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A Case Study on Knowledge Driven Code Generation for Software-Defined Industrial Cyber-Physical Systems
- 2018
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Ingår i: Proceedings IECON 2018. - : IEEE. ; , s. 4687-4692
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Konferensbidrag (refereegranskat)abstract
- Industrial Cyber-Physical Systems (iCPS) enables coordination between various subsystems and devices based on real-time feedback data from sensors. iCPS must react rapidly to new requirements and adjust itself to fulfill new functionalities in no time. On the software side, control programs of iCPS need to be reconfigured dynamically. An efficient way for massive reconfiguration is automatic code generation. In this paper, a knowledge-driven code generation method is experimented for software-defined iCPS. Based on sensor values, actuators are controlled by the reasoning process with support of ontological knowledge base. The results demonstrate that iCPS could be driven by rules completely without programming control software.
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| 3. |
- Dai, Wenbin, et al.
(författare)
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Modelling Industrial Cyber-Physical Systems using IEC 61499 and OPC UA
- 2018
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Konferensbidrag (refereegranskat)abstract
- Industrial Cyber-Physical Systems (iCPS) are considered as the enabling technology for achieve Industry 4.0. One main characteristic of the iCPS is the information transparency to allow interoperability among various devices and systems. The OPC UA provides a common information model for connecting Industry 4.0 components. On the other hand, the IEC 61499 is commonly used as an executable modeling language for iCPS. The IEC 61499 function block network provides an abstract view of the system configuration. By combining IEC 61499 and OPC UA, a visual executable model for iCPS is completed. In this paper, the mapping between two standards are provided and a case study of the proposed mapping is given.
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