| 1. |
- Wu, Wei, et al.
(författare)
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Roles of Mitogen-Activated Protein Kinases in the Modulation of Endothelial Cell Function Following Thermal Injury
- 2011
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Ingår i: Shock. - : Biomedical Press. - 1073-2322 .- 1540-0514. ; 35:6, s. 618-625
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Tidskriftsartikel (refereegranskat)abstract
- Several mitogen-activated protein kinases (MAPKs) are activated during thermal injury, and the p38 MAPK is specifically involved in endothelial cell (EC) actin and myosin rearrangement (stress-fiber formation) with ensuing cellular contraction and enhanced vessel permeability. Inhibition of p38 MAPK and extracellular signal-related kinase MAPK by their inhibitors SB203580 and PD98059, respectively, significantly reduces burn serum-induced EC stress-fiber formation, whereas SB203580 also inhibits burn serum-induced EC tight-junction damage and thereby general blood vessel hyperpermeability. The JNK MAPK inhibitor, SP600125, on the contrary, influences neither stress-fiber formation nor EC tight-junction damage. Extracellular signal-related kinase MAPK inhibition significantly decreases burn serum-induced Monocyte chemotactic protein-1 (MCP-1) release, whereas SB203580 and SP600125 have only limited such effects. Western blotting, real-time reverse transcriptase-polymerase chain reaction, and confocal laser scanning microscopy proved that SP600125 significantly inhibits burn serum-induced intercellular adhesion molecule 1 expression, whereas SB203580 depresses the expression of P selectin. In vivo studies, using the dominant negative adenoviral approach of MAPK kinase 3b and MAPK kinase 6b to block p38 MAPKs, and MKK4 and MKK7 to block JNK MAPKs, show that the latter MAPKs are involved in the regulation of P selectin and intercellular adhesion molecule 1 expression, respectively, following thermal injury. Taken together, the results suggest that several MAPKs play important, although different, roles in general EC alterations following burn injuries.
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| 2. |
- C. Manchaiah, Vinaya K., 1983-, et al.
(författare)
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The role of communication partners in the audiological enablement/rehabilitation of a person with hearing impairment : An overview
- 2012
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Ingår i: Audiological Medicine. - 1651-386X .- 1651-3835. ; 10:1, s. 21-30
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Hearing impairment is known to have various effects upon both the person with hearing impairment (PHI) and their communication partners (CPs). In addition, CPs are reported to play an important role in making the decision to seek a consultation and the acceptance of intervention by the PHI. The overall aim of this paper is to provide a comprehensive overview of the role of the CP in the audiological enablement/rehabilitation of the PHI keeping clinical practice in focus. Method: A literature review was conducted using a number of resources including electronic databases, books and websites. Results: An overview of the literature was presented in the following sections: 1) Factors influencing the audiological enablement/rehabilitation of the PHI; 2) Effect of the PHI's hearing impairment on their CPs; 3) CPs’ influence on their PHI's audiological enablement/rehabilitation; 4) Positive experiences reported by CPs of the PHI; 5) Models to represent CPs within the social network context of the PHI; and 6) CP involvement in the audiological enablement/rehabilitation. This paper also identifies gaps in the literature and provides recommendations for further research. Conclusion: It is clear that involvement of the CP in the audiological enablement/rehabilitation can result in mutual advantages for both the PHI and their CPs.
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| 3. |
- Deng, Min, et al.
(författare)
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Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
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Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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| 4. |
- Fei, Z., et al.
(författare)
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Experimental and theoretical study of the ground-state M1 transition in Ag-like tungsten
- 2012
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 86:6
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Tidskriftsartikel (refereegranskat)abstract
- We present an experimental and theoretical study of the F-2(5/2) -> F-2(7/2) M1 transition in Ag-like W (W27+). The experiments employed the Shanghai permanent magnet electron beam ion trap, which has been developed especially for assisting spectroscopic diagnostics of edge plasmas for magnetic fusion devices. The theoretical value was obtained using the GRASP2K set of computer codes and included a comprehensive correlation study. The experimental M1 wavelength was measured as 3377.43 +/- 0.26 angstrom (3378.43 angstrom vacuum wavelength), whereas the calculated wavelength is in good agreement at 3381.80 angstrom. This good agreement shows the importance of fully understanding the electron correlation effects to predict the energy of the fine structure even in this, for tungsten, relatively simple case.
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| 5. |
- Fei, Z., et al.
(författare)
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Forbidden-line spectroscopy of the ground-state configuration of Cd-like W
- 2014
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Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 90:5
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Tidskriftsartikel (refereegranskat)abstract
- only using electric-dipole forbidden emission lines, in what we label forbidden-line spectroscopy, we identified several energy levels in cadmium-like tungsten, W26+. The spectrum was recorded at the Shanghai permanentmagnet electron beam ion trap in the visible region. The identifications were supported by large-scale multiconfiguration Dirac-Hartree-Fock calculations which involved careful investigations of core-valence and core-core correlation effects, and by relativistic many-body perturbation theory calculations. With this novel method we identified in all seven lines and measured their wavelengths. From this we can determine the relative position of seven energy levels. Due to the close degeneracy of two levels, we give alternative energies for three of the levels.
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| 6. |
- Feng, Chungang, et al.
(författare)
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A cis-Regulatory Mutation of PDSS2 Causes Silky-Feather in Chickens
- 2014
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Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 10:8, s. e1004576-
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Tidskriftsartikel (refereegranskat)abstract
- Silky-feather has been selected and fixed in some breeds due to its unique appearance. This phenotype is caused by a single recessive gene (hookless, h). Here we map the silky-feather locus to chromosome 3 by linkage analysis and subsequently fine-map it to an 18.9 kb interval using the identical by descent (IBD) method. Further analysis reveals that a C to G transversion located upstream of the prenyl (decaprenyl) diphosphate synthase, subunit 2 (PDSS2) gene is causing silky-feather. All silky-feather birds are homozygous for the G allele. The silky-feather mutation significantly decreases the expression of PDSS2 during feather development in vivo. Consistent with the regulatory effect, the C to G transversion is shown to remarkably reduce PDSS2 promoter activity in vitro. We report a new example of feather structure variation associated with a spontaneous mutation and provide new insight into the PDSS2 function.
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| 7. |
- Feng, Feng, et al.
(författare)
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Room-temperature large magnetic-dielectric coupling in new phase anatase VTiO4
- 2013
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Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; 49:89, s. 10462-10464
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Tidskriftsartikel (refereegranskat)abstract
- The synthetic new-phase VTiO4, as a new solid solution structure of anatase type, brings a large magnetodielectric ratio (Delta epsilon/epsilon(0)) of 7.2% at 300 K, representing a new simple-oxide structural catalogue exhibiting a room-temperature large magnetic-dielectric effect.
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| 8. |
- Manchaiah, Vinaya K. C., 1983-, et al.
(författare)
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Professor Dafydd Stephens 1942–2012
- 2012
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Ingår i: International Journal of Audiology. - : Informa Healthcare. - 1499-2027 .- 1708-8186. ; 51:10, s. 714-714
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Manchaiah, Vinaya K. C., 1983-, et al.
(författare)
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Storytelling in different cultural context: Applications to hearing loss public awareness campaign
- 2012
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Ingår i: Journal of Behavioral Health. - : ScopeMed. - 2146-8346. ; 1:4, s. 322-329
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Tidskriftsartikel (refereegranskat)abstract
- Hearing impairment is known to be one of the most frequent sensory impairments. This condition is known to be a hidden disorder which is under recognised and under treated all around the world. The World Health Organisation (WHO) estimates suggest that there are over 275 million people with hearing impairment and 80% of them living in low and middle income countries. Moreover, the estimates suggest that incidence and prevalence of hearing loss and also the number of people with hearing loss accessing services varies considerably across countries. This rises the need for health promotion (or public awareness campaigns) directed to increase awareness and education of hearing loss and hearing healthcare. This paper provides brief discussion on ‘Stories and storytelling’, ‘Cross-culture and cross-cultural communication’ and ‘Health promotion and cultural sensitivity’. The central focus of this paper is to highlight the applications of storytelling in different cultural context in health promotion, particularly to hearing loss public awareness campaigns.
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| 10. |
- Manchaiah, Vinaya K. C., 1983-, et al.
(författare)
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The genetic basis of auditory neuropathy spectrum disorder (ANSD)
- 2011
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Ingår i: International Journal of Pediatric Otorhinolaryngology. - : Elsevier. - 0165-5876 .- 1872-8464. ; 75:2, s. 151-158
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Auditory neuropathy is a hearing disorder where outer hair cell function within the cochlea is normal, but inner hair cell and/or the auditory nerve function is disrupted. It is a heterogeneous disorder which can have either congenital or acquired causes. Furthermore, the aetiology of auditory neuropathy is vast, which may include prematurity, hyperbilirubinaemia, anoxia, hypoxia, congenital brain anomalies, ototoxic drug exposure, and genetic factors. It is estimated that approximately 40% of cases have an underlying genetic basis, which can be inherited in both syndromic and non syndromic conditions. This review paper provides an overview of the genetic conditions associated with auditory neuropathy spectrum disorders (ANSDs) and highlights some of the defective genes that have been found to be linked to the pathological auditory changes.Method: Literature search was conducted using a number of resources including textbooks, professional journals and the relevant websites. Results: The largest proportion of auditory neuropathy spectrum disorders (ANSDs) is due to genetic factors which can be syndromic, non-syndromic or mitochondrial related. The inheritance pattern can include all the four main types of inheritances such as autosomal dominant, autosomal recessive, X-linked and mitochondrial. Conclusion: This paper has provided an overview of mutation with some of the genes and/or loci discovered to be the cause for auditory neuropathy spectrum disorders (ANSDs). It has been noted that different gene mutations may trigger different pathological changes in patients with this disorder. These discoveries have provided us with vital information as to the sites of pathology in auditory neuropathy spectrum disorders (ANSDs), and the results highlight the heterogeneity of the disorder.
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