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Vitamin D levels an...
Vitamin D levels and busulphan kinetics in patients undergoing hematopoietic stem cell transplantation, a multicenter study
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- El-Serafi, Ahmed, 1977- (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.;Suez Canal Univ, Med Biochem & Mol Biol Dept, Fac Med, Ismailia, Egypt.
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- He, Rui (author)
- Karolinska Institutet
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- Zheng, Wenyi (author)
- Karolinska Institutet
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- Benkossou, Fadwa (author)
- Karolinska Inst, Div Clin Res Ctr, Dept Lab Med, Expt Canc Med, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Clin Res Ctr, Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, Ctr Allogene Stem Cell Transplantat CAST, Stockholm, Sweden.
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- Oerther, Sandra (author)
- Karolinska Institutet
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- Zhao, Ying (author)
- Karolinska Institutet
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- Mellgren, Karin (author)
- Sahlgrens Univ Hosp, Dept Pediat Oncol, Gothenburg, Region Vastra G, Sweden.
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- Gustafsson, Britt (author)
- Karolinska Institutet
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- Heilmann, Carsten (author)
- Natl Univ Hosp, Pediat Clin, Rigshosp, Copenhagen, Denmark.
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- Kanerva, Jukka (author)
- HUS Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, New Childrens Hosp, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.
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- Lotfi, Kourosh, 1966- (author)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för klinisk kemi och farmakologi,Region Östergötland, Hematologiska kliniken US,Linköping Univ, Clin Pharmacol, Div Drug Res, Dept Med & Hlth Sci, Linköping, Sweden.;Linköping Univ Hosp, Dept Hematol, Linköping, Sweden.
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- Toporski, Jacek (author)
- Skane Univ Hosp, Dept Pediat, Lund, Sweden.
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- Sundin, Mikael (author)
- Karolinska Institutet
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi,Uppsala Univ, Sweden
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- Mattsson, Jonas (author)
- Karolinska Institutet
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- El-Serafi, Ibrahim (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Port Said Univ, Dept Biochem, Fac Med, Port Said, Egypt.
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- Hassan, Moustapha (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-10-21
- 2021
- English.
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In: Bone Marrow Transplantation. - : SPRINGERNATURE. - 0268-3369 .- 1476-5365. ; 56, s. 807-817
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Vitamin D (Vit-D), an essential nutrient, interacts with different drugs including chemotherapeutic agents like busulphan, an alkylating agent used for conditioning prior to stem cell transplantation. The correlation between Vit-D plasma levels and busulphan clearance was investigated in an uncontrolled prospective study in patients and mice. Plasma 25(OH)D levels were measured and busulphan pharmacokinetics calculated in 81 patients. Adults received oral busulphan (n = 34) while children received busulphan orally (n = 19) or intravenously (n = 28). Patients received no Vit-D supplementation. To confirm our findings, pharmacokinetics after a single dose of busulphan (oral or intravenous) were evaluated in two groups of mice (n = 60) receiving high or standard-level Vit-D supplementation. Both busulphan clearance (P < 0.0001) and 25(OH)D levels (P = 0.0004) were significantly higher in adults compared to children. A significant negative correlation (P = 0.041) was found between busulphan clearance and 25(OH)D levels in children treated orally. No such correlation was observed in adults or in children receiving intravenous busulphan. In addition, no significant effect of Vit-D levels on busulphan pharmacokinetics in mice regardless of the administration route. In conclusion, 25(OH)D can affect oral busulphan pharmacokinetics in children and its level should be considered when personalizing oral busulphan treatment. Further studies are warranted to confirm the underlying mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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El-Serafi, Ahmed ...
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He, Rui
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Zheng, Wenyi
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Benkossou, Fadwa
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Oerther, Sandra
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Zhao, Ying
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show more...
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Mellgren, Karin
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Gustafsson, Brit ...
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Heilmann, Carste ...
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Kanerva, Jukka
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Lotfi, Kourosh, ...
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Toporski, Jacek
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Sundin, Mikael
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Höglund, Martin
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Mattsson, Jonas
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El-Serafi, Ibrah ...
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Hassan, Moustaph ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Bone Marrow Tran ...
- By the university
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Linköping University
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Uppsala University
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Karolinska Institutet