Sökning: WFRF:(Zhou Zongguang)
> (2022) >
Preoperative short-...
Preoperative short-course radiotherapy followed by consolidation chemotherapy for treatment with locally advanced rectal cancer : a meta-analysis
-
- Wu, Haoyan (författare)
- Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China
-
- Fan, Chuanwen (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China
-
- Fang, Chao (författare)
- Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China
-
visa fler...
-
- Huang, Libin (författare)
- Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China
-
- Li, Yuan (författare)
- Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China
-
- Zhou, Zongguang (författare)
- Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China; Sichuan Univ, Peoples R China
-
visa färre...
-
(creator_code:org_t)
- 2022-01-24
- 2022
- Engelska.
-
Ingår i: Radiation Oncology. - : BMC. - 1748-717X. ; 17:1
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://ro-journal.b...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background The addition of consolidation chemotherapy to preoperative short-course radiotherapy during the prolonged interval between the completion of radiation and surgery in locally advanced rectal cancer (LARC) could enhance pathologic response and might act on potential micrometastasis. We performed this meta-analysis to evaluate whether short-course radiotherapy followed by consolidation chemotherapy (SCRT/CCT) could be a neoadjuvant treatment option compared with conventional long-course chemoradiotherapy (LCCRT). Methods We searched the PubMed, EMBASE, MEDLINE, and Cochrane Library databases. The primary endpoints were pathological outcomes, and the secondary endpoints included survival rate, sphincter preservation rate, R0 resection rate and toxicity. RevMan 5.3 was used to calculate pooled risk ratio (RRs) and 95% confidence intervals (CIs). Results A total of seven eligible studies and 1865 participants were included in this meta-analysis. Compared with the LCCRT, SCRT/CCT increased pathologic complete response (pCR) rate [RR = 1.74, 95% CI (1.41, 2.15), P < 0.01] and led to a lower proportion of patients with adjuvant pathologic tumor stage 3-4 (ypT3-4) disease [RR = 0.88, 95% CI (0.80, 0.97), P = 0.01] or lymph node positive (ypN +) disease [RR = 0.83, 95% CI (0.71, 0.98), P = 0.02]. In addition, the disease-free survival (DFS) was better in SCRT/CCT group [RR = 1.10, 95% CI (1.02, 1.18), P = 0.01], while overall survival rate and toxicity and surgical procedures were similar between two groups. Conclusion Based on better pathological outcomes and DFS in SCRT/CCT group, we recommended preoperative short-course radiotherapy followed by consolidation chemotherapy as the optional neoadjuvant treatment for LARC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Rectal cancer; Short-course radiotherapy; Consolidation chemotherapy; Meta-analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas