| 1. |
- Deng, Min, et al.
(författare)
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Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis
- 2013
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 45:6, s. 697-
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Tidskriftsartikel (refereegranskat)abstract
- To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.
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| 2. |
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| 3. |
- Fei, Y Y, et al.
(författare)
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Use of real-time, label-free analysis in revealing low-affinity binding to blood group antigens by Helicobacter pylori
- 2011
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 83:16, s. 6336-6341
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Tidskriftsartikel (refereegranskat)abstract
- Infectious diseases are often initiated by microbial adherence that is mediated by the binding of attachment molecules, termed adhesins, to cell surface receptors on host cells. We present an experimental system, oblique-incidence reflectivity difference (OI-RD) microscopy, which allows the detection of novel, low-affinity microbial attachment mechanisms that may be essential for infectious processes. OI-RD microscopy was used to analyze direct binding of the oncopathogen, Helicobacter pylori ( H. pylori ) to immobilized glycoconjugates in real time with no need for labeling tags. The results suggest the presence of additional Lewis b blood group antigen (Le(b)) binding adhesins that have not been detected previously. OI-RD microscopy also confirmed the high-affinity binding of H. pylori outer-membrane protein BabA to Le(b). The OI-RD microscopy method is broadly applicable to real-time characterization of intact microbial binding to host receptors and offers new strategies to elucidate the molecular interactions of infectious agents with human host cells.
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| 4. |
- Li, Fei, et al.
(författare)
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Cognitive radio spectrum sharing using improved Quantum Genetic Algorithm
- 2011
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Ingår i: 2011 International Conference on Wireless Communications and Signal Processing, WCSP 2011. - : IEEE. - 9781457710100 - 9781457710094
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Konferensbidrag (refereegranskat)abstract
- A key challenge in cognitive radios (CR) network is how to adaptively and efficiently allocate transmission powers and spectrum among CR users according to the surrounding environment. In this paper, we propose a novel spectrum sharing based on our improved Quantum Genetic Algorithm (QGA) in a non-cooperative game for CR network. We improved the original QGA by quantum crossover operator, in order to overcome the shortcoming of the original QGA easily falling into a local extremum when used to optimize the continuous functions with many extrema. We used our improved QGA as a competitive strategy and conducted several simulations in two-user system and multi-user system. From simulation results, it is evident that the proposed improved QGA based spectrum sharing scheme has better convergence rate and higher sum capacity than GA based scheme even in multi-user CR system, namely up to 2bit/s/Hz increase in capacity. The simulation results also show that the population size of QGA affect sum capacity of cognitive radio system. The results demonstrated the effectiveness and the applicability of QGA in spectrum sharing in multi-user cognitive radio system.
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| 5. |
- Li, Fei, et al.
(författare)
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Improved quantum genetic algorithm for competitive spectrum sharing in cognitive radios
- 2012
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Ingår i: 2011 International Conference in Electrics, Communication and Automatic Control Proceedings. - New York, NY : Springer. - 9781441988485 - 9781441988492 ; , s. 1203-1209
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Konferensbidrag (refereegranskat)abstract
- This chapter investigates a kind of whole new approach to spectrum sharing in cognitive radio (CR) system, quantum-inspired approach. First, we improved Quantum Genetic Algorithm (QGA) by adding quantum crossover operator to overcome the shortcomings of the original QGA, easily falling into a local extremum when used to optimize the continuous functions with many extrema. We then propose a novel spectrum sharing scheme in noncooperative game for CR system based on our improved QGA. We use QGA as competitive strategies and provide simulation results that confirm the proposed schemes have better convergence rate and higher sum capacity than genetic algorithm (GA)-based scheme, namely at most 1 bit/s/Hz increase in capacity. The results demonstrate the effectiveness and the applicability of QGA in spectrum sharing in CR system.
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| 6. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:10, s. 1113-1120
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Forskningsöversikt (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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