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Alpha1-antitrypsin ...
Alpha1-antitrypsin protects the immature mouse brain following hypoxic-ischemic injury
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- Zhang, Shan (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Li, W. D. (författare)
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Xu, Y. R. (författare)
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- Li, Tao (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Ek, C. Joakim (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Zhang, X. L. (författare)
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- Wang, Yafeng, 1985 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Song, J. (författare)
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- Zhu, Changlian, 1964 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Wang, Xiaoyang, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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(creator_code:org_t)
- 2023-03-06
- 2023
- Engelska.
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Ingår i: Frontiers in Cellular Neuroscience. - : Frontiers Media SA. - 1662-5102. ; 17
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Preterm brain injury often leads to lifelong disabilities affecting both cognitive and motor functions, and effective therapies are limited. Alpha1-antitrypsin (AAT), an endogenous inhibitor of serine proteinases with anti-inflammatory, anti-apoptotic, and cytoprotective properties, might be beneficial in treating preterm brain injury. The aim of this study was to investigate whether AAT has neuroprotective effects in a mouse preterm brain injury model.Methods: Preterm brain injury was induced on postnatal day 5, and mouse pups' right common carotid arteries were cut between two ligations followed by hypoxia induction. Brain injury was evaluated through immunohistochemistry staining and magnetic resonance imaging. Fluoro-Jade B and immunohistochemistry staining were performed to investigate the neuronal cell death and blood-brain barrier (BBB) permeability. The motor function and anxiety-like behaviors were revealed by CatWalk gait analysis and the open field test.Results: After hypoxia-ischemia (HI) insult, brain injury was alleviated by AAT treatment, and this was accompanied by reduced BBB permeability, reduced neuronal cell death and caspase-3 activation, and inhibition of microglia activation. In addition, AAT administration significantly improved HI-induced motor function deficiencies in mice. The neuroprotective effect of AAT was more pronounced in male mice.Conclusion: AAT treatment is neuroprotective against preterm brain injury in neonatal mice, and the effect is more pronounced in males.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- alpha1-antitrypsin
- neuroprotection
- hypoxia-ischemia
- neonatal brain
- injury
- immature brain
- motor dysfunction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhang, Shan
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Li, W. D.
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Xu, Y. R.
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Li, Tao
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Ek, C. Joakim
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Zhang, X. L.
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visa fler...
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Wang, Yafeng, 19 ...
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Song, J.
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Zhu, Changlian, ...
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Wang, Xiaoyang, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Neurovetenskaper
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Frontiers in Cel ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet