| 1. |
- Jurva, Risto, et al.
(författare)
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White paper on business of 6G : 6G research visions, No 3
- 2020
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- 6G vision and the industry consensus of underlying technology enablers have come a long way and will shape the new access, networking, and service domains in future mobile communications. These novel features promise countless opportunities for service innovation and business efficiencies, creating an unprecedented impact on multiple vertical sectors. 6G will connect worlds in novel and innovative ways – the physical and digital worlds will be deeply intertwined in real time, human biological systems will be seamlessly coupled, and at the same time, there will be a new human sensory and cognitive dimension across the scenarios of the 6G experience. Key technology-enabling themes to be explored will include the pervasive leverage of machine learning and artificial intelligence across architectural domains to flexibly define the air interface, as well as service management and orchestration in the 6G “network of networks” topology and platform ecosystem. Terahertz (THz) research is one of the prominent topics, utilizing spectral bands of above 100 GHz for both communications and sensing purposes, thereby enabling connectivity data speeds in the Terabit/s range. We foresee millions of sub-networks and devices becoming the network in conjunction with extreme performance attributes in terms of both sub-millisecond latency, high reliability and time-sensitive determinism, and advanced ways to assure security, privacy, and trust. In line with 6G vision and technology enablers, developing products, services, and vertical applications for the future digitized society in the 6G era requires a multidisciplinary approach and a redefinition of how we create, deliver, and consume network resources, data, and services for both communications and sensing purposes. This development will change and disrupt the traditional business models and ecosystem roles of digital service providers, as well as open the market for key stakeholders in the 6G era like digital service operators, cloud operators, and resource brokers. Furthermore, sustainable Abstract development is a highly complex area that will call for major changes in industrialized society in the long run. This white paper discusses the unprecedented opportunities to enable and empower multiple stakeholders to more actively participate in the future 6G ecosystem via novel sustainable open ecosystemic business models with flexible integration of long tail services with tailored performance attributes. This research adopts a qualitative scenario planning method, portraying three scenario themes resulting in a total of 12 scenarios for the futures of the 6G business. We present both optimistic and pessimistic scenarios, and assess their probability, plausibility, and preferability. By focusing on key trends, their interactions, and irreducible uncertainties, scenario building generates perspectives for the futures within which alternative 6G business strategies have been developed and assessed for a traditional incumbent mobile network operator, and a novel 6G digital service provider stemming from redefined sustainable economics. Value capture in the 6G era requires an understanding of the dynamics of platforms and ecosystems. The results indicate that to reach some of the preferred futures, we should attend to the privacy and security issues related to business and regulation needs: public/governmental, corporate, community, and user perspectives on and aims of governance; ecosystem configuration related to users, decentralized business models, and platforms; user empowerment; and the role of service location-specificity.
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| 2. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 3. |
- Uusitalo, Mikko A., et al.
(författare)
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6G Vision, Value, Use Cases and Technologies from European 6G Flagship Project Hexa-X
- 2021
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Ingår i: IEEE Access. - 2169-3536 .- 2169-3536. ; 9, s. 160004-160020
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Tidskriftsartikel (refereegranskat)abstract
- While 5G is being deployed and the economy and society begin to reap the associated benefits, the research and development community starts to focus on the next, 6th Generation (6G) of wireless communications. Although there are papers available in the literature on visions, requirements and technical enablers for 6G from various academic perspectives, there is a lack of joint industry and academic work towards 6G. In this paper a consolidated view on vision, values, use cases and key enabling technologies from leading industry stakeholders and academia is presented. The authors represent the mobile communications ecosystem with competences spanning hardware, link layer and networking aspects, as well as standardization and regulation. The second contribution of the paper is revisiting and analyzing the key concurrent initiatives on 6G. A third contribution of the paper is the identification and justification of six key 6G research challenges: (i) “connecting”, in the sense of empowering, exploiting and governing, intelligence; (ii) realizing a network of networks, i.e., leveraging on existing networks and investments, while reinventing roles and protocols where needed; (iii) delivering extreme experiences, when/where needed; (iv) (environmental, economic, social) sustainability to address the major challenges of current societies; (v) trustworthiness as an ingrained fundamental design principle; (vi) supporting cost-effective global service coverage. A fourth contribution is a comprehensive specification of a concrete first-set of industry and academia jointly defined use cases for 6G, e.g., massive twinning, cooperative robots, immersive telepresence, and others. Finally, the anticipated evolutions in the radio, network and management/orchestration domains are discussed.
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| 4. |
- Uusitalo, Mikko A., et al.
(författare)
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Hexa-X: The european 6G flagship project
- 2021
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Ingår i: 2021 Joint European Conference on Networks and Communications and 6G Summit, EuCNC/6G Summit 2021. ; , s. 580-585
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Konferensbidrag (refereegranskat)abstract
- Hexa-X will pave the way to the next generation of wireless networks (Hexa) by explorative research (X). The Hexa-X vision is to connect human, physical, and digital worlds with a fabric of sixth generation (6G) key enablers. The vision is driven by the ambition to contribute to objectives of growth, global sustainability, trustworthiness, and digital inclusion. Key 6G value indicators and use cases are defined against the background of technology push, society and industry pull as well as objectives of technology sovereignty. Key areas of research have been formulated accordingly to include connecting intelligence, network of networks, sustainability, global service coverage, extreme experience, and trustworthiness. Critical technology enablers for 6G are developed in the project including, sub-THz transceiver technologies, accurate stand-alone positioning and radio-based imaging, improved radio performance, artificial intelligence (AI) / machine learning (ML) inspired radio access network (RAN) technologies, future network architectures and special purpose solutions including future ultra-reliable low-latency communication (URLLC) schemes. Besides technology enablers, early trials will be carried out to help assess viability and performance aspects of the key technology enablers. The 6G Hexa-X project is integral part of European and global research effort to help define the best possible next generation of networks.
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| 5. |
- Valenta, Vaclav, et al.
(författare)
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Design and experimental evaluation of compensated bondwire interconnects above 100 GHz
- 2015
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Ingår i: International journal of microwave and wireless technologies. - 1759-0795 .- 1759-0787. ; 7:3-4, s. 261-270
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Tidskriftsartikel (refereegranskat)abstract
- Different types of bondwire interconnect for differential chip-to-antenna and single-ended chip-to-chip interfaces are investigated. Two differential compensation structures for various lengths of interconnects are designed and experimentally evaluated using dedicated transmit and receive radar modules operating across a 110-156 GHz band. Measurement results demonstrate that a fractional bandwidth of 7.5% and a minimum insertion loss of 0.2 dB can be achieved for differential interconnects as long as 0.8 mm. Design and measurement results of an extremely wideband low-loss single-ended chip-to-chip bondwire interconnect that features 1.5 dB bandwidth from DC to 170 GHz and insertion loss of less than 1 dB at 140 GHz are presented as well. The results show that the well-established wire-bonding techniques are still an attractive solution even beyond 100 GHz. Reproducibility and scalability of the proposed solutions are assessed as well.
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| 6. |
- Wagner, Stephan, et al.
(författare)
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Irrationality of Growth Constants Associated with Polynomial Recursions
- 2021
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Ingår i: Journal of Integer Sequences. - : UNIV WATERLOO. - 1530-7638. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- We consider integer sequences that satisfy a recursion of the form x(n+1) = P(x(n)) for some polynomial P of degree d > 1. If such a sequence tends to infinity, then it satisfies an asymptotic formula of the form x(n) similar to A alpha(dn), but little can be said about the constant alpha. In this paper, we show that ff is always irrational or an integer. In fact, we prove a stronger statement: if a sequence (G(n))(n >= 0) satisfies an asymptotic formula of the form G(n) = A alpha(n) + B + O(alpha(-epsilon n)), where A, B are algebraic and alpha > 1, and the sequence contains infinitely many integers, then ff is irrational or an integer.
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| 7. |
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| 8. |
- Zaharia, Oana P., et al.
(författare)
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Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes : a 5-year follow-up study
- 2019
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Ingår i: The Lancet Diabetes and Endocrinology. - 2213-8587. ; 7:9, s. 684-694
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Tidskriftsartikel (refereegranskat)abstract
- Background: Cluster analyses have proposed different diabetes phenotypes using age, BMI, glycaemia, homoeostasis model estimates, and islet autoantibodies. We tested whether comprehensive phenotyping validates and further characterises these clusters at diagnosis and whether relevant diabetes-related complications differ among these clusters, during 5-years of follow-up. Methods: Patients with newly diagnosed type 1 or type 2 diabetes in the German Diabetes Study underwent comprehensive phenotyping and assessment of laboratory variables. Insulin sensitivity was assessed using hyperinsulinaemic-euglycaemic clamps, hepatocellular lipid content using magnetic resonance spectroscopy, hepatic fibrosis using non-invasive scores, and peripheral and autonomic neuropathy using functional and clinical criteria. Patients were reassessed after 5 years. The German Diabetes Study is registered with ClinicalTrials.gov, number NCT01055093, and is ongoing. Findings: 1105 patients were classified at baseline into five clusters, with 386 (35%) assigned to mild age-related diabetes (MARD), 323 (29%) to mild obesity-related diabetes (MOD), 247 (22%) to severe autoimmune diabetes (SAID), 121 (11%) to severe insulin-resistant diabetes (SIRD), and 28 (3%) to severe insulin-deficient diabetes (SIDD). At 5-year follow-up, 367 patients were reassessed, 128 (35%) with MARD, 106 (29%) with MOD, 88 (24%) with SAID, 35 (10%) with SIRD, and ten (3%) with SIDD. Whole-body insulin sensitivity was lowest in patients with SIRD at baseline (mean 4·3 mg/kg per min [SD 2·0]) compared with those with SAID (8·4 mg/kg per min [3·2]; p<0·0001), MARD (7·5 mg/kg per min [2·5]; p<0·0001), MOD (6·6 mg/kg per min [2·6]; p=0·0011), and SIDD (5·5 mg/kg per min [2·4]; p=0·0035). The fasting adipose-tissue insulin resistance index at baseline was highest in patients with SIRD (median 15·6 [IQR 9·3–20·9]) and MOD (11·6 [7·4–17·9]) compared with those with MARD (6·0 [3·9–10·3]; both p<0·0001) and SAID (6·0 [3·0–9·5]; both p<0·0001). In patients with newly diagnosed diabetes, hepatocellular lipid content was highest at baseline in patients assigned to the SIRD cluster (median 19% [IQR 11–22]) compared with all other clusters (7% [2–15] for MOD, p=0·00052; 5% [2–11] for MARD, p<0·0001; 2% [0–13] for SIDD, p=0·0083; and 1% [0–3] for SAID, p<0·0001), even after adjustments for baseline medication. Accordingly, hepatic fibrosis at 5-year follow-up was more prevalent in patients with SIRD (n=7 [26%]) than in patients with SAID (n=5 [7%], p=0·0011), MARD (n=12 [12%], p=0·012), MOD (n=13 [15%], p=0·050), and SIDD (n=0 [0%], p value not available). Confirmed diabetic sensorimotor polyneuropathy was more prevalent at baseline in patients with SIDD (n=9 [36%]) compared with patients with SAID (n=10 [5%], p<0·0001), MARD (n=39 [15%], p=0·00066), MOD (n=26 [11%], p<0·0001), and SIRD (n=10 [17%], p<0·0001). Interpretation: Cluster analysis can characterise cohorts with different degrees of whole-body and adipose-tissue insulin resistance. Specific diabetes clusters show different prevalence of diabetes complications at early stages of non-alcoholic fatty liver disease and diabetic neuropathy. These findings could help improve targeted prevention and treatment and enable precision medicine for diabetes and its comorbidities. Funding: German Diabetes Center, German Federal Ministry of Health, Ministry of Culture and Science of the state of North Rhine-Westphalia, German Federal Ministry of Education and Research, German Diabetes Association, German Center for Diabetes Research, Research Network SFB 1116 of the German Research Foundation, and Schmutzler Stiftung.
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| 9. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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