Sökning: WFRF:(de Boer Gijs)
> (2024) >
The enigma of scler...
The enigma of sclera-specific autoimmunity in scleritis
-
- Vergouwen, Daphne P. C. (författare)
- Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.;Dept ophthalmol, Erasmus MC, Dr Molewaterplein 40, NL-3015GD Rotterdam, Netherlands.
-
- van Beek, Adriaan A. (författare)
- Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands.
-
- de Hoog, Joeri (författare)
- Dept Ophthalmol, Amsterdam UMC, Amsterdam, Netherlands.
-
visa fler...
-
- de Boer, Joke H. (författare)
- Dept Ophthalmol, UMC Utrecht, Utrecht, Netherlands.
-
- Los, Leonoor I. (författare)
- Dept Ophthalmol, UMC Groningen, Groningen, Netherlands.
-
- Gijs, Marlies (författare)
- Univ Eye Clin, Maastricht UMC, Maastricht, Netherlands.
-
- Erckens, Roel J. (författare)
- Univ Eye Clin, Maastricht UMC, Maastricht, Netherlands.
-
- Verdijk, Rob M. (författare)
- Univ Med Ctr Rotterdam, Dept Pathol, Erasmus MC, Rotterdam, Netherlands.
-
- Haasnoot, Geert W. (författare)
- Leiden Univ Med Ctr, Eurotransplant Reference Lab, Leiden, Netherlands.
-
- Roelen, Dave L. (författare)
- Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands.
-
- Rothova, Aniki (författare)
- Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.
-
- Rönnelid, Johan (författare)
- Uppsala universitet,Vaskulärbiologi
-
- Berge, Josianne C. Ten (författare)
- Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.
-
- Schreurs, Marco W. J. (författare)
- Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.
-
visa färre...
-
Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands;Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.;Dept ophthalmol, Erasmus MC, Dr Molewaterplein 40, NL-3015GD Rotterdam, Netherlands. Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
-
Ingår i: Journal of Autoimmunity. - : Elsevier. - 0896-8411 .- 1095-9157. ; 144
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA). Further, sclera-specific antibodies were determined using indirect immunofluorescence (IIF) on primate retinal/scleral cryosections. Lastly, human leukocyte antigen (HLA) typing was performed in 111 patients with scleritis. Anti-type II collagen antibodies were found in 13% of scleritis patients, in 10% of healthy controls and in 11% of uveitis controls (p = 0.91). A specific reaction to scleral nerve tissue on IIF was observed in 33% of patients with scleritis, which was higher than in healthy controls (11%; p = 0.01), but similar to uveitis controls (25%; p = 0.36). Reactivity to the scleral nerve tissue was significantly associated with earlier onset of scleritis (48 versus 56 years; p < 0.001), bilateral involvement (65% versus 42%; p = 0.01), and less frequent development of scleral necrosis (5% versus 22%; p = 0.02). HLA-B27 was found to be twice as prevalent in patients with scleritis (15.3%) compared to a healthy population (7.2%). In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Scleritis
- Autoimmunity
- Autoantibodies
- Type II collagen antibodies
- HLA-Association
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Vergouwen, Daphn ...
-
van Beek, Adriaa ...
-
de Hoog, Joeri
-
de Boer, Joke H.
-
Los, Leonoor I.
-
Gijs, Marlies
-
visa fler...
-
Erckens, Roel J.
-
Verdijk, Rob M.
-
Haasnoot, Geert ...
-
Roelen, Dave L.
-
Rothova, Aniki
-
Rönnelid, Johan
-
Berge, Josianne ...
-
Schreurs, Marco ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Journal of Autoi ...
- Av lärosätet
-
Uppsala universitet