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Germline mutation i...
Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer
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- Candido-dos-Reis, Francisco J (författare)
- University of São Paulo
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- Song, Honglin (författare)
- University of Cambridge
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- Goode, Ellen L (författare)
- Mayo Clinic Minnesota
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- Cunningham, Julie M (författare)
- Mayo Clinic Minnesota
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- Fridley, Brooke L (författare)
- University of Kansas Medical Center
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- Larson, Melissa C (författare)
- Mayo Clinic Minnesota
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- Alsop, Kathryn (författare)
- Peter MacCallum Cancer Centre
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- Dicks, Ed (författare)
- University of Cambridge
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- Harrington, Patricia (författare)
- University of Cambridge
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- Ramus, Susan J (författare)
- University of Southern California
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- de Fazio, Anna (författare)
- University of Sydney
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- Mitchell, Gillian (författare)
- Peter MacCallum Cancer Centre
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- Fereday, Sian (författare)
- Peter MacCallum Cancer Centre
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- Bolton, Kelly L (författare)
- National Cancer Institute, USA
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- Gourley, Charlie (författare)
- University of Edinburgh
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- Michie, Caroline (författare)
- Ninewells Hospital and Medical School
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- Karlan, Beth (författare)
- Cedars-Sinai Medical Center
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- Lester, Jenny (författare)
- Cedars-Sinai Medical Center
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- Walsh, Christine (författare)
- Cedars-Sinai Medical Center
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- Cass, Ilana (författare)
- Cedars-Sinai Medical Center
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- Olsson, Håkan (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Gore, Martin (författare)
- Royal Marsden NHS Foundation Trust
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- Benitez, Javier J (författare)
- Spanish National Cancer Research Center (CNIO)
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- Garcia, Maria J (författare)
- Spanish National Cancer Research Center (CNIO)
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- Andrulis, Irene (författare)
- University of Toronto
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- Mulligan, Anna Marie (författare)
- University of Toronto
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- Glendon, Gord (författare)
- University of Toronto
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- Blanco, Ignacio (författare)
- Catalan Institute of Oncology
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- Lazaro, Conxi (författare)
- Catalan Institute of Oncology
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- Whittemore, Alice S (författare)
- Stanford University
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- McGuire, Valerie (författare)
- Stanford University
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- Sieh, Weiva (författare)
- Stanford University
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- Montagna, Marco (författare)
- Veneto Institute of Oncology
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- Alducci, Elisa (författare)
- Veneto Institute of Oncology
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- Sadetzki, Siegal (författare)
- Gertner Institute for Epidemiology and Health Policy Research
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- Chetrit, Angela (författare)
- Gertner Institute for Epidemiology and Health Policy Research
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- Kwong, Ava (författare)
- Hong Kong Sanatorium & Hospital
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- Kjaer, Susanne K (författare)
- Danish Cancer Society
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- Jensen, Allan (författare)
- Danish Cancer Society
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- Høgdall, Estrid (författare)
- University of Copenhagen
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- Neuhausen, Susan (författare)
- Beckman Research Institute of City of Hope
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- Nussbaum, Robert (författare)
- University of California, San Francisco
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- Daly, Mary (författare)
- Fox Chase Cancer Center
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- Greene, Mark H (författare)
- National Cancer Institute, USA
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- Mai, Phuong L (författare)
- National Cancer Institute, USA
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- Loud, Jennifer T (författare)
- National Cancer Institute, USA
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- Moysich, Kirsten (författare)
- Roswell Park Cancer Institute
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- Toland, Amanda E (författare)
- Ohio State University
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- Lambrechts, Diether (författare)
- Catholic University of Leuven
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- Ellis, Steve (författare)
- University of Cambridge
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(creator_code:org_t)
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- 2015
- 2015
- Engelska 6 s.
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Ingår i: Clinical Cancer Research. - 1078-0432. ; 21:3, s. 7-652
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE: To analyze the effect of germline mutations in BRCA1 and BRCA2 on mortality in patients with ovarian cancer up to 10 years after diagnosis.EXPERIMENTAL DESIGN: We used unpublished survival time data for 2,242 patients from two case-control studies and extended survival time data for 4,314 patients from previously reported studies. All participants had been screened for deleterious germline mutations in BRCA1 and BRCA2. Survival time was analyzed for the combined data using Cox proportional hazard models with BRCA1 and BRCA2 as time-varying covariates. Competing risks were analyzed using Fine and Gray model.RESULTS: The combined 10-year overall survival rate was 30% [95% confidence interval (CI), 28%-31%] for non-carriers, 25% (95% CI, 22%-28%) for BRCA1 carriers, and 35% (95% CI, 30%-41%) for BRCA2 carriers. The HR for BRCA1 was 0.53 at time zero and increased over time becoming greater than one at 4.8 years. For BRCA2, the HR was 0.42 at time zero and increased over time (predicted to become greater than 1 at 10.5 years). The results were similar when restricted to 3,202 patients with high-grade serous tumors and to ovarian cancer-specific mortality.CONCLUSIONS: BRCA1/2 mutations are associated with better short-term survival, but this advantage decreases over time and in BRCA1 carriers is eventually reversed. This may have important implications for therapy of both primary and relapsed disease and for analysis of long-term survival in clinical trials of new agents, particularly those that are effective in BRCA1/2 mutation carriers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Aged
- Female
- Genes, BRCA1
- Genes, BRCA2
- Germ-Line Mutation
- Humans
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Neoplasms, Glandular and Epithelial
- Ovarian Neoplasms
- Prognosis
- Survival Analysis
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, Non-P.H.S.
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Candido-dos-Reis ...
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Song, Honglin
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Goode, Ellen L
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Cunningham, Juli ...
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Fridley, Brooke ...
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Larson, Melissa ...
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visa fler...
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Alsop, Kathryn
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Dicks, Ed
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Harrington, Patr ...
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Ramus, Susan J
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de Fazio, Anna
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Mitchell, Gillia ...
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Fereday, Sian
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Bolton, Kelly L
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Gourley, Charlie
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Michie, Caroline
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Karlan, Beth
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Lester, Jenny
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Walsh, Christine
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Cass, Ilana
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Olsson, Håkan
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Gore, Martin
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Benitez, Javier ...
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Garcia, Maria J
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Andrulis, Irene
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Mulligan, Anna M ...
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Glendon, Gord
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Blanco, Ignacio
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Lazaro, Conxi
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Whittemore, Alic ...
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McGuire, Valerie
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Sieh, Weiva
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Montagna, Marco
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Alducci, Elisa
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Sadetzki, Siegal
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Chetrit, Angela
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Kwong, Ava
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Kjaer, Susanne K
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Jensen, Allan
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Høgdall, Estrid
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Neuhausen, Susan
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Nussbaum, Robert
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Daly, Mary
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Greene, Mark H
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Mai, Phuong L
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Loud, Jennifer T
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Moysich, Kirsten
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Toland, Amanda E
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Lambrechts, Diet ...
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Ellis, Steve
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